A sterile oleaginous solution containing per mL: Nandrolone Decanoate 200 mg with Benzyl Alcohol 5% as solubilizer/preservative, in Sesame Oil q.s. Nandrolone decanoate (C28H44O3) occurs as a fine, white to creamy white, crystalline powder. It is odorless, or may have a slight odor. Nandrolone decanoate is soluble in chloroform, in alcohol, in acetone, and in vegetable oils. It is practically insoluble in water.
Nandrolone decanoate is indicated for the management of the anemia of renal insufficiency and has been shown to increase hemoglobin and red cell mass. Surgically induced anephric patients have been reported to be less responsive.
Published Studies Related to Nandrolone
Therapeutic effects of nandrolone and testosterone in adult male HIV patients with AIDS wasting syndrome (AWS): a randomized, double-blind, placebo-controlled trial. [2010.07]
PURPOSE: We aimed to compare therapeutic effects of intramuscular (IM) nandrolone decanoate and IM testosterone enanthate in male HIV patients with AIDS wasting syndrome (AWS) with placebo control... CONCLUSION: Our trial demonstrates the superior therapeutic effects of nandrolone in male AWS patients, including the androgen deficient.
Influence of delivery mode on the urinary excretion of nandrolone metabolites. [2010.04]
INTRODUCTION: This study examined the influence of a supplement matrix on the excretion pattern of nandrolone metabolites in response to ingestion of a trace amount of 19-norandrostenedione... CONCLUSIONS: Peak 19-NA concentrations were higher, and occurred later, when the 19-norandrostenedione was added to a solid supplement. This may be due to a slower rate of absorption and/or a reduced diuresis, resulting in a longer period for the metabolites to accumulate in the urine.
Nandrolone excretion in sedentary vs physically trained young women. [2010.02]
We investigated the effects of the menstrual cycle, oral contraception and physical training on exhaustive exercise-induced changes in the excretion of nandrolone metabolites [19-norandrosterone (19-NA), and 19-noretiocholanolone (19-NE)] in young women...
Beneficial effects of nandrolone decanoate in wasting associated with HIV. [2009.05]
Recent studies have demonstrated the role of nandrolone decanoate (ND) in reversal of wasting associated with HIV infection. However, such studies in Indian scenario are lacking... Nandrolone therapy may prove to be effective and safe in reversing wasting associated with Indian HIV patients on antiretroviral therapy (ART) and nutritional replacement.
Effects of testosterone and nandrolone on cardiac function: a randomized, placebo-controlled study. [2007.02]
Background Androgens have striking effects on skeletal muscle, but the effects on human cardiac muscle function are not well defined, neither has the role of metabolic activation (aromatization, 5alpha reduction) of testosterone on cardiac muscle been directly studied.Conclusion Four weeks of treatment with testosterone or nandrolone had no benefical or adverse effects compared with placebo on cardiac function in healthy young men.
Clinical Trials Related to Nandrolone
A Study to Evaluate the Effect of Nandrolone Decanoate in Women With HIV-Associated Weight Loss [Completed]
The purpose of this study is to see if giving nandrolone decanoate (a hormonal drug) will
cause weight gain in HIV-positive women who have HIV-associated weight loss (wasting).
Wasting has become an AIDS-defining condition. In the past, most studies that examined
wasting treatments were limited to men. However, it appears that wasting in HIV-positive
men is linked to levels of testosterone (a hormone which affects men's bodies more than
women's). This study has been designed for women only, in order to best treat wasting in
The Effect of Nandrolone Decanoate and Leucine on Muscle Loss [Not yet recruiting]
A decrease in muscle mass can have a profound impact on quality of life, as it can lead to
decreased strength, insulin resistance, lower basal metabolic rate and obesity. With this
study we investigate whether ingesting leucine or getting a ND injection will reduce the
loss of muscle mass and strength.
Nandrolone Decanoate in the Treatment of Telomeropathies [Recruiting]
Decrease in blood cell counts due to deficient bone marrow function, called bone marrow
failure, as well as some lung diseases, called idiopathic pulmonary fibrosis, can be caused
by genetic defects in telomere biology genes, eventually causing telomere erosion. These
disorders are collectively termed "telomeropathies".
There is evidence that male hormones may improve blood cell counts in marrow failure, and
these hormones are able to stimulate telomerase function in hematopoietic cells in vitro. We
propose this study to the use of male hormone in patients with aplastic anemia and pulmonary
fibrosis associated with defects in telomeres.
Anabolic Steroids for Nutritional Rehabilitation of Critically Ill Patients [Terminated]
This prospective, double-blinded study will determine the feasibility of determining the
efficacy of a weekly intramuscular injection of nandrolone (an anabolic steroid) in
malnourished ICU patients. The data from this study will also enable us to prepare a future
grant proposal with a calculated sample size necessary to demonstrate an improvement in
Risk of Positive Doping Tests Following Ingestion of Supplements Contaminated With Trace Quantities of Nandrolone Metabolites [Completed]
There is compelling evidence that some dietary supplements consumed by the general
population are manufactured and stored under conditions that lead to contamination of the
end product with small amounts of extraneous materials. In most cases, this is harmless, but
for athletes liable to drug testing as a consequence of their participation in sport, the
potential consequences of even trivial amounts of a prohibited substance may be
catastrophic. Quality control procedures for pharmaceutical products normally specify the
absence of contaminants at a level of more than 0. 1%, ie 1mg/g. However, in the case of an
anabolic steroid such as nandrolone, the amount that will cause a positive test has been
estimated to be about 1-3µg (Geyer et al, 2004). In the case of a supplement that is taken
in high doses (20-30 g/d), such as for example creatine, this means that a contamination
level of something closer to 0. 00001% (ie 1µg/g) may cause a positive test. This work have
been supported by recent findings from our laboratory (Judkins et al, 2006). These data
demonstrate that as little as 10μg of 19-noradrostenedione (19-NorAD) added to a creatine
supplement resulted in a positive doping test in all volunteers testing. This is one
thousand times less that the purity level specified for pharmaceutical agents and at this
level, these contaminants are without any pharmacological action.
Proposals are under development to regulate the sale of dietary supplements for use by
athletes to avoid accidental doping positives as a result of ingestion of contaminated
supplements. This requires a knowledge of the amounts of contaminant that is likely to cause
problems. The aim of the present study was to examine the urinary excretion pattern of
nandrolone metabolites following 1µg, 2. 5µg and 5µg doses of 19-norandrostendione in both
male and female subjects. The quantity of 19-norandrostenedione administered in this study
is representative of the amount previously reported as an undeclared contaminant in some
dietary supplements. Given the speculation surrounding positive doping cases being
attributed to ingestion of sports supplements contaminated with pro-hormones, this presents
an important consideration for both athletes and doping agencies, as well as supplement
Page last updated: 2011-12-09