NEWS HIGHLIGHTS
Published Studies Related to Nandrolone
Therapeutic effects of nandrolone and testosterone in adult male HIV patients with AIDS wasting syndrome (AWS): a randomized, double-blind, placebo-controlled trial. [2010.07]
PURPOSE: We aimed to compare therapeutic effects of intramuscular (IM) nandrolone decanoate and IM testosterone enanthate in male HIV patients with AIDS wasting syndrome (AWS) with placebo control... CONCLUSION: Our trial demonstrates the superior therapeutic effects of nandrolone in male AWS patients, including the androgen deficient.
Influence of delivery mode on the urinary excretion of nandrolone metabolites. [2010.04]
INTRODUCTION: This study examined the influence of a supplement matrix on the excretion pattern of nandrolone metabolites in response to ingestion of a trace amount of 19-norandrostenedione... CONCLUSIONS: Peak 19-NA concentrations were higher, and occurred later, when the 19-norandrostenedione was added to a solid supplement. This may be due to a slower rate of absorption and/or a reduced diuresis, resulting in a longer period for the metabolites to accumulate in the urine.
Nandrolone excretion in sedentary vs physically trained young women. [2010.02]
We investigated the effects of the menstrual cycle, oral contraception and physical training on exhaustive exercise-induced changes in the excretion of nandrolone metabolites [19-norandrosterone (19-NA), and 19-noretiocholanolone (19-NE)] in young women...
Beneficial effects of nandrolone decanoate in wasting associated with HIV. [2009.05]
Recent studies have demonstrated the role of nandrolone decanoate (ND) in reversal of wasting associated with HIV infection. However, such studies in Indian scenario are lacking... Nandrolone therapy may prove to be effective and safe in reversing wasting associated with Indian HIV patients on antiretroviral therapy (ART) and nutritional replacement.
Effects of testosterone and nandrolone on cardiac function: a randomized, placebo-controlled study. [2007.02]
Background Androgens have striking effects on skeletal muscle, but the effects on human cardiac muscle function are not well defined, neither has the role of metabolic activation (aromatization, 5alpha reduction) of testosterone on cardiac muscle been directly studied.Conclusion Four weeks of treatment with testosterone or nandrolone had no benefical or adverse effects compared with placebo on cardiac function in healthy young men.
Clinical Trials Related to Nandrolone
A Study to Evaluate the Effect of Nandrolone Decanoate in Women With HIV-Associated Weight Loss [Completed]
The purpose of this study is to see if giving nandrolone decanoate (a hormonal drug) will
cause weight gain in HIV-positive women who have HIV-associated weight loss (wasting).
Wasting has become an AIDS-defining condition. In the past, most studies that examined
wasting treatments were limited to men. However, it appears that wasting in HIV-positive men
is linked to levels of testosterone (a hormone which affects men's bodies more than women's).
This study has been designed for women only, in order to best treat wasting in HIV-positive
women.
Risk of Positive Doping Tests Following Ingestion of Supplements Contaminated With Trace Quantities of Nandrolone Metabolites [Completed]
There is compelling evidence that some dietary supplements consumed by the general population
are manufactured and stored under conditions that lead to contamination of the end product
with small amounts of extraneous materials. In most cases, this is harmless, but for athletes
liable to drug testing as a consequence of their participation in sport, the potential
consequences of even trivial amounts of a prohibited substance may be catastrophic. Quality
control procedures for pharmaceutical products normally specify the absence of contaminants
at a level of more than 0. 1%, ie 1mg/g. However, in the case of an anabolic steroid such as
nandrolone, the amount that will cause a positive test has been estimated to be about 1-3µg
(Geyer et al, 2004). In the case of a supplement that is taken in high doses (20-30 g/d),
such as for example creatine, this means that a contamination level of something closer to
0. 00001% (ie 1µg/g) may cause a positive test. This work have been supported by recent
findings from our laboratory (Judkins et al, 2006). These data demonstrate that as little as
10μg of 19-noradrostenedione (19-NorAD) added to a creatine supplement resulted in a positive
doping test in all volunteers testing. This is one thousand times less that the purity level
specified for pharmaceutical agents and at this level, these contaminants are without any
pharmacological action.
Proposals are under development to regulate the sale of dietary supplements for use by
athletes to avoid accidental doping positives as a result of ingestion of contaminated
supplements. This requires a knowledge of the amounts of contaminant that is likely to cause
problems. The aim of the present study was to examine the urinary excretion pattern of
nandrolone metabolites following 1µg, 2. 5µg and 5µg doses of 19-norandrostendione in both
male and female subjects. The quantity of 19-norandrostenedione administered in this study is
representative of the amount previously reported as an undeclared contaminant in some dietary
supplements. Given the speculation surrounding positive doping cases being attributed to
ingestion of sports supplements contaminated with pro-hormones, this presents an important
consideration for both athletes and doping agencies, as well as supplement manufacturers.
Assessment of the Treatment of Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation [Recruiting]
The purpose of the program is to study and characterize the outcome of burn injury with
particular attention to improving the rehabilitation of burn survivors, including children.
Various agents are assessed for effectiveness on long term burn outcome, such as growth
hormone, oxandrolone, propranolol,ketoconazole, inhospital exercise and home exercise.
Anabolic Steroids for Nutritional Rehabilitation of Critically Ill Patients [Recruiting]
This prospective, double-blinded study will determine the feasibility of determining the
efficacy of a weekly intramuscular injection of nandrolone (an anabolic steroid) in
malnourished ICU patients. The data from this study will also enable us to prepare a future
grant proposal with a calculated sample size necessary to deomonstrate an improvement in
clinical outcome.
Anabolic Steroids and Exercise in Hemodialysis Patients [Completed]
This is a study to find out whether an exercise program during dialysis or a drug called
nandrolone decanoate can increase muscle size and strenght in patients on dialysis.
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