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Namenda (Memantine Hydrochloride) - Summary

 
 



NAMENDA SUMMARY

Namenda® Tablets/Oral Solution
(memantine hydrochloride)

NAMENDA™ (memantine hydrochloride) is an orally active NMDA receptor antagonist.

NAMENDA (memantine hydrochloride) is indicated for the treatment of moderate to severe dementia of the Alzheimer's type.


See all Namenda indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Namenda (Memantine)

Link between sleep disturbance and amyloid in brain areas affected by Alzheimer's disease
Source: Seniors / Aging News From Medical News Today [2014.12.12]
Healthy, elderly research participants who report being more sleepy and less rested have higher levels of amyloid deposition in regions of the brain that are affected in Alzheimer's disease...

Researchers at Mainz University explore new approach for treating Alzheimer's disease
Source: Seniors / Aging News From Medical News Today [2014.12.09]
It is estimated that about 35 million people worldwide currently suffer from dementia and it is expected that the number will increase to 135 million by the year 2050.

Breakdown in brain connection identified in early Alzheimer's disease
Source: MRI / PET / Ultrasound News From Medical News Today [2014.12.02]
Changes in brain connections visible on MRI could represent an imaging biomarker of Alzheimer's disease, according to a new study presented at the annual meeting of the Radiological Society of North...

Laying siege to beta-amyloid, the key protein in Alzheimer's disease
Source: Huntingtons Disease News From Medical News Today [2014.10.06]
The peptide - a small protein - beta-amyloid is strongly associated with Alzheimer's disease; however, researchers are still looking for unequivocal proof that this peptide is the causal agent of the...

Alzheimer's Disease
Source: MedicineNet Swallowing Specialty [2014.08.05]
Title: Alzheimer's Disease
Category: Symptoms and Signs
Created: 8/5/2014 2:43:00 PM
Last Editorial Review: 8/5/2014 2:43:52 PM

more news >>

Published Studies Related to Namenda (Memantine)

Memantine in patients with moderate to severe Alzheimer's disease: meta-analyses using realistic definitions of response. [2014]
analysis of memantine... CONCLUSIONS: New definitions of clinical worsening based on MIDs represent a more

Genotype variant associated with add-on memantine in bipolar II disorder. [2014]
Memantine is a non-competitive N-methyl-d-asparate (NMDA) receptor antagonist with a mood-stabilizing effect. We investigated whether using valproic acid (VPA) plus add-on memantine to treat bipolar II disorder (BP-II) is more effective than using VPA alone (VPA + Pbo)...

Vitamin E and memantine in Alzheimer's disease: clinical trial methods and baseline data. [2014]
and (iv) placebo in delaying clinical progression in AD... CONCLUSION: This large multicenter trial will address the unanswered question of

Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder. [2013]
Memantine is a noncompetitive NMDA receptor antagonist...

Memantine add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: randomized, double-blind, placebo-controlled study. [2013]
We aimed to evaluate the efficacy of memantine add-on in the treatment of primary negative symptoms of patients with stable schizophrenia. In a double-blind placebo-controlled clinical trial, 40 patients with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) who were stabilized on risperidone for a minimum of 8 weeks were randomized to either memantine (20 mg) or placebo in addition to risperidone, 6 mg/d, for eight weeks...

more studies >>

Clinical Trials Related to Namenda (Memantine)

Memantine and Intensive Speech-Language Therapy in Aphasia [Completed]

- Aphasia, the loss or impairment of language caused by brain damage, is one of the most

devastating cognitive impairments of stroke. Aphasia can be treated with combination of speech-language therapy and drugs. Conventional speech-language therapy in chronic aphasic subjects is of little help and several drugs have been studied with limited success. Therefore other therapeutic strategies are warranted.

- Recent data suggest that drugs (memantine) acting on the brain chemical glutamate may

help the recovery of cognitive deficits, included language, in subjects with vascular dementia. The present study examines the safety profile and efficacy of memantine paired with intensive language therapy in subjects with stroke-related chronic aphasia (more than 1 yr. of evolution).

Effect of Namenda on Short Term Memory and Attention in Patients With Mild to Moderate Traumatic Brain Injury [Recruiting]
The purpose of this study is to determine whether memantine (Namenda) improves memory and attention in patients with mild to moderate traumatic brain injury.

A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease [Recruiting]
The primary study hypothesis is that compared with placebo, alpha-tocopherol, memantine (Namenda), or the combination will significantly delay clinical progression in mild to moderately demented patients with Alzheimer's disease.

Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy [Not yet recruiting]
People with epilepsy often experience problems with their memories and other thinking skills that get worse over time. The investigators hope to learn more about whether a drug called memantine can help improve or stabilize (keep the same) memory and other thought processes in people with epilepsy by blocking a chemical that is released in the brain during seizures. The investigators also want to see if memantine changes the frequency (how often) people with epilepsy have seizures. Memantine is currently approved by the United States Food and Drug Administration (FDA) for treatment of patients with Alzheimer's disease.

A Study of Memantine Hydrochloride (Namenda�) for Cognitive and Behavioral Impairment in Adults With Autism Spectrum Disorders [Recruiting]
The main objective of this study is to evaluate the safety and effectiveness of memantine (Namenda) for cognitive and behavioral impairment in adults ages 18-45 years with autism spectrum disorders (ASD). This is an exploratory, 12-week, pilot study, seeking to determine whether Namenda is efficacious and well tolerated in the treatment of adults with ASD. The study results will be used to generate hypotheses for a larger randomized controlled clinical trial with explicit hypotheses and sufficient statistical power.

more trials >>

Reports of Suspected Namenda (Memantine) Side Effects

Confusional State (7)Dizziness (5)Abnormal Behaviour (5)Tremor (5)Movement Disorder (4)Drug Interaction (4)OFF Label USE (4)Asthenia (4)Thinking Abnormal (3)Balance Disorder (3)more >>


Page last updated: 2014-12-12

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