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Naloxone (Naloxone Hydrochloride) - Summary

 


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NALOXONE SUMMARY

NALOXONE HYDROCHLORIDE INJECTION USP
Narcotic Antagonist

Naloxone hydrochloride, a narcotic antagonist, is a synthetic congener of oxymorphone. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group.17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochlorideC19H21NO4• HCl          363.84

Naloxone hydrochloride injection is indicated for the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and certain narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. Naloxone hydrochloride is also indicated for the diagnosis of suspected acute opioid overdosage.

Naloxone hydrochloride injection may be useful as an adjunctive agent to increase blood pressure in the management of septic shock.


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NALOXONE NEWS HIGHLIGHTS

Published Studies Related to Naloxone

Acylated ghrelin inhibits spontaneous luteinizing hormone pulsatility and responsiveness to naloxone but not that to gonadotropin-releasing hormone in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. [2008.09]

Buprenorphine/naloxone treatment in primary care is associated with decreased human immunodeficiency virus risk behaviors. [2008.07]

Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children. [2008.05]

A study of naloxone effect on urinary retention in the patient receiving morphine patient-controlled analgesia. [2008.03]

Long-term treatment with buprenorphine/naloxone in primary care: results at 2-5 years. [2008.03]

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Clinical Trials Related to Naloxone

Safety and Tolerability of Buprenorphine/Naloxone Film Strips [Active, not recruiting]

Preference for Subutex® (Buprenorphine) Versus Suboxone® (Buprenorphin/Naloxone) in Opioid Dependent Patients on Subutex (Study P05094)(COMPLETED) [Completed]

Abuse Potential of Buprenorphine/Naloxone [Terminated]

Determine the Safety of a Sublingual Tablet Formulation of Buprenorphine and Naloxone by Extending the Combination Tablet Availability to Physicians in Office-Based Practice [Completed]

Pharmacokinetic Interactions Between Buprenorphine and Tipranavir/Ritonavir [Completed]

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Page last updated: 2008-11-03

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