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Nalbuphine (Nalbuphine Hydrochloride) - Summary

 


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NALBUPHINE SUMMARY

NALBUPHINE HYDROCHLORIDE Injection

Nalbuphine Hydrochloride Injection is a sterile, nonpyrogenic solution of nalbuphine hydrochloride in water for injection. This product may be administered by subcutaneous, intramuscular or intravenous injection. Each milliliter (mL) contains nalbuphine hydrochloride 10 mg or 20 mg; sodium citrate, dihydrate 0.47 mg and citric acid, anhydrous 0.63 mg added as buffers and may contain sodium hydroxide and/or hydrochloric acid for pH adjustment; pH 3.7 (3.0 to 4.5). Contains sodium chloride for tonicity adjustment. Multiple-dose vials contain 1.8 mg/mL methylparaben and 0.2 mg/mL propylparaben added as preservatives. Single-dose products contain no bacteriostat or antimicrobial agent and unused portions must be discarded.

Nalbuphine hydrochloride is indicated for the relief of moderate to severe pain. Nalbuphine hydrochloride can also be used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.


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NALBUPHINE NEWS HIGHLIGHTS

Published Studies Related to Nalbuphine

Combination of opioid agonist and agonist-antagonist: patient-controlled analgesia requirement and adverse events among different-ratio morphine and nalbuphine admixtures for postoperative pain. [2008.10]

Tramadol versus nalbuphine in total intravenous anaesthesia for dilatation and evacuation. [2007.02]

Intravenous nalbuphine 50 {micro}g{middle dot}kg-1 is ineffective for opioid-induced pruritus in pediatrics: [La nalbuphine intraveineuse a 50 {micro}g{middle dot}kg-1 est inefficace contre le prurit induit par les opioides chez des enfants]. [2006.11]

A randomized clinical trial of continuous flow nitrous oxide and nalbuphine infusion for sedation of patients during radiofrequency atrial flutter ablation. [2006.04]

Prevention of emergence agitation after sevoflurane anesthesia for pediatric cerebral magnetic resonance imaging by small doses of ketamine or nalbuphine administered just before discontinuing anesthesia. [2006.04]

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Clinical Trials Related to Nalbuphine

Nalbuphine for the Treatment of Opioid Induced Pruritus in Children [Active, not recruiting]

Interaction Between Nalbuphine and Morphine in PCA [Recruiting]

Ketamine and Postoperative Analgesia in Children [Recruiting]

Analgesic Strategies in Newborns Receiving Prostaglandin Therapy [Terminated]

Effects of Additional Fentanyl to Epidural Bupivacaine for Post-Thoracotomy Pain in Neonates [Completed]

more >>

Page last updated: 2008-11-03

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