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Nalbuphine (Nalbuphine Hydrochloride) - Summary

 
 



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NALBUPHINE SUMMARY

Nalbuphine hydrochloride is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series.

Nalbuphine hydrochloride is indicated for the relief of moderate to severe pain. Nalbuphine hydrochloride can also be used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.


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NEWS HIGHLIGHTS

Published Studies Related to Nalbuphine

Pharmacokinetics of nalbuphine hydrochloride after intravenous and intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis). [2011.06]
OBJECTIVE: To assess the pharmacokinetics of nalbuphine HCl after IV and IM administration to Hispaniolan Amazon parrots (Amazona ventralis). ANIMALS: 8 healthy adult Hispaniolan Amazon parrots of unknown sex...

Antinociceptive effects of nalbuphine hydrochloride in Hispaniolan Amazon parrots (Amazona ventralis). [2011.06]
OBJECTIVE: To evaluate the antinociceptive effects and duration of action of nalbuphine HCl administered IM on thermal thresholds in Hispaniolan Amazon parrots (Amazona ventralis). ANIMALS: 14 healthy adult Hispaniolan Amazon parrots of unknown sex...

Comparison between tramadol hydrochloride & nalbuphine hydrochloride in the treatment of per-operative shivering after spinal anaesthesia. [2011.04]
Per-operative shivering following spinal anaesthesia is a common problem in the operation theatre.This study was also done to observe the incidence of shivering during operation following spinal anesthesia.

Efficacy of intramuscular nalbuphine versus diphenhydramine for the prevention of epidural morphine-induced pruritus after cesarean delivery. [2011.03]
BACKGROUND: Pruritus is the most common side effect of epidural morphine analgesia. Diphenhydramine is a widely used agent for the treatment of urticarial pruritus. Nalbuphine is a mixed opioid agonist-antagonist and has been reported to be effective in treating opioid-induced pruritus. We compared the effectiveness of intramuscular diphenhydramine and nalbuphine for the prevention of epidural morphine-induced pruritus after cesarean section... CONCLUSION: Nalbuphine proved better than diphenhydramine for prevention of epidural morphine-induced pruritus in patients who underwent cesarean section. Prophylactic intramuscular nalbuphine (10 mg) is effective in decreasing the incidence and severity of pruritus and does not affect analgesia.

Effect of treatment with a topical ophthalmic preparation of 1% nalbuphine solution on corneal sensitivity in clinically normal horses. [2010.02]
OBJECTIVE: To assess the effect of treatment with a topical ophthalmic preparation of 1.2% nalbuphine solution on corneal sensitivity in clinically normal horses... The topical ocular treatment was not associated with local irritation.

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Clinical Trials Related to Nalbuphine

Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus [Recruiting]
The primary objective of the study is to evaluate the overall safety of nalbuphine HCL ER tablets during a treatment period of up to 24 weeks.

Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis [Recruiting]
The primary objectives of the study are to evaluate the effects of two doses of nalbuphine HCl ER tablets on the change from baseline in the worst itch Numerical Rating Scale (NRS) in patients with prurigo nodularis and to evaluate the safety and tolerability in the study population.

Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus [Active, not recruiting]
The primary objectives of the study to evaluate the effects of two doses of nalbuphine HCl ER tablets on the change from baseline in the worst itch Numerical Rating Scale (NRS) in hemodialysis patients with moderate to severe uremic pruritus and to evaluate the safety and tolerability in the study population.

Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis [Not yet recruiting]
The primary objective of the study is to evaluate the overall safety of nalbuphine HCL ER tablets during a treatment period of up to 50 weeks.

Epidural Nalbuphine for Postcesarean Epidural Morphine Induced Pruritus [Completed]

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Page last updated: 2011-12-09

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