Media Articles Related to Myoview (Tetrofosmin)
APA Leaders Defend New Diagnostic Guide
Source: MedPage Today Cardiovascular [2013.05.18]
SAN FRANCISCO (MedPage Today) -- The fifth edition of the "psychiatrist's bible" was officially released here in all its 947-page glory, with its developers offering a spirited rebuttal to their critics.
Topol on Using Smartphones for Complex Diagnostic Challenges
Source: Medscape Allergy & Clinical Immunology Headlines [2013.05.15]
Eric J. Topol, MD, describes how smartphones and supercomputers will partner to help clinicians with challenging medical diagnoses and treatments.
FDA Approves New Lung Cancer Diagnostic "Cobas EGFR Mutation Test"
Source: Cancer / Oncology News From Medical News Today [2013.05.15]
The U.S. Food and Drug Administration (FDA) has approved the cobas EGFR Mutation Test, a companion diagnostic for the cancer drug Tarceva (erlotinib). This is the first FDA-approved companion diagnostic that detects epidermal growth factor receptor (EGFR) gene mutations, which are present in approximately 10 percent of non-small cell lung cancers (NSCLC)...
Medical Diagnostic Device Employs Wireless Signals To Identify Brain Swelling Or Bleeding
Source: Medical Devices / Diagnostics News From Medical News Today [2013.05.15]
New technology developed at the University of California, Berkeley, is using wireless signals to provide real-time, non-invasive diagnoses of brain swelling or bleeding. The device analyzes data from low energy, electromagnetic waves, similar to the kind used to transmit radio and mobile signals...
FDA Approves Companion Genetic Diagnostic Test for Tarceva
Source: Medscape Today Headlines [2013.05.14]
The FDA has approved the first companion diagnostic test that can detect EGFR mutations in non-small cell lung cancer.
Published Studies Related to Myoview (Tetrofosmin)
Relationship of technetium-99m tetrofosmin-gated rest single-photon emission computed tomography myocardial perfusion imaging to death and hospitalization in heart failure patients: results from the nuclear ancillary study of the HF-ACTION trial. [2011.06]
BACKGROUND: We hypothesized that the severity of resting perfusion abnormalities assessed by the summed rest score (SRS) would be associated with a higher rate of adverse outcomes in patients with heart failure (HF) and reduced left ventricular (LV) ejection fraction (EF)... CONCLUSIONS: Gated SPECT MPI provides important information in patients with HF and reduced LVEF. In the adjusted analysis, SRS has an unexpected relationship with the primary end point. Phase SD was not associated with the primary end point. Rest-gated SPECT MPI provides incrementally greater prognostic information than clinical information alone. Copyright (c) 2011 Mosby, Inc. All rights reserved.
Acceleration of hepatobiliary excretion by lemon juice on 99mTc-tetrofosmin cardiac SPECT. [2006.11]
BACKGROUND: We sought to determine whether drinking lemon juice reduces extra-cardiac activity and improves image quality on (99m)Tc-tetrafosmin myocardial single photon emission computed tomography (SPECT)... CONCLUSION: Drinking 250 ml of diluted lemon juice accelerates the transit of tetrofosmin through the liver parenchyma and improves image quality on (99m)Tc-tetrafosmin myocardial SPECT.
Placebo or trimetazidine (99m)Tc tetrofosmin myocardial SPECT and low-dose dobutamine echocardiography in hibernating myocardium. [2006.01]
BACKGROUND: Trimetazidine (TMZ) improves (99m)Tc sestamibi uptake in myocardial single photon emission tomography (SPECT). This study compared TMZ (99m)Tc tetrofosmin SPECT and low-dose dobutamine echocardiography (LDDE) as predictors of functional recovery of hibernating myocardium after coronary revascularization... CONCLUSIONS: The addition of TMZ to (99m)Tc tetrofosmin SPECT improved diagnostic accuracy. The importance of hibernating myocardium revascularization was confirmed.
Tetrofosmin early time gated post-stress single-photon emission computed tomography imaging: feasibility and potential benefits. [2011.02]
BACKGROUND: The purpose of this study is to evaluate the feasibility, the image quality, and the clinical relevance of an early gated post-stress (GPS) single-photon emission computed tomography (SPECT) tetrofosmin (Myoview-GE Healthcare) acquisition protocol. Time delay between myocardial technetium-labeled tracer administration and SPECT acquisition is usually about 30 minutes after stress, and 45 to 60 minutes at rest: because of the absence of significant redistribution, perfusion images are related to stress even 30 minutes after stress injection, while function and thickening data obtained with gated acquisition 30 minutes after stress are mainly related to rest conditions... CONCLUSIONS: Tetrofosmin early GPS-SPECT is feasible without impairment of image quality (better count rate). Ischemic defect size on early post-stress images is slightly more pronounced than at 30 minutes: this could modify therapeutic decision. This technique produces reliable function information during early post-stress period, and might be useful for disclosing transient motion abnormalities.
Countermeasures against physical motion in schoolchildren requiring no sedation during rest and stress myocardial perfusion imaging with technetium-99m-tetrofosmin. [2011.01]
For children, cardiac nuclear medicine imaging has not been widely used because of problems of physical motion, even in schoolchildren who require no sedation. In this study, rest-stress myocardial perfusion imaging (MPI) with technetium-99m-tetrofosmin (Tc-99m TF) was performed with the use of a Vac-Loc cushion, a patient immobilizer commonly used for radiotherapy, for immobilizing school-age patients...
Clinical Trials Related to Myoview (Tetrofosmin)
Comparison of Diagnostic Rest/Stress SPECT Results for Patients With Myocardial Ischemia and Infarction Using Myoview in Both Single and Dual Isotope Acquisition Approaches [Completed]
The study is designed to determine whether a dual isotope protocol is equivalent to a single
isotope in the diagnosis of myocardial ischemia and infarction using MYOVIEW SPECT imaging.
Acute Chest Pain Treatment and Evaluation (ACTION) Study
1. To compare the incidence of adverse cardiac events among the patients discharged after
evaluation through ACTION protocol with those through conventional protocol. The adverse
cardiac events for the follow-up are defined as any of the followings:
- Cardiac related death
- Ventricular fibrillation
- Myocardial infarction
- Cardiogenic shock requiring the inta-aortic balloon pump circulatory assistance
- Acute pulmonary oedema requiring endo-tracheal intubation
2. To study the sensitivity / predictive values of the various components of ACTION :12
lead ECG ST monitoring , serial serum markers for myocardial necrosis (myoglobin, CKMB,
TnT, graded exercise testing, stress tetrofosmin scan/ stress echocardiography) in
predicting adverse cardiac events.
Design - prospective randomised clinical trial
- patients above 25 years of age presenting to the ED with chest pain consistent with
myocardial ischaemia but with a 12 lead ECG non-diagnostic of myocardial ischaemia .
Patients were monitored continuously with a 12 lead ECG and ST segment trend monitoring and
blood will be drawn at 0,3,6 hours after arrival at ED for serial myoglobin, creatine kinase
MB isoenzyme (CKMB) and Troponin T (TnT) . Patients who have ECG and blood test consistent
with myocardial necrosis were admitted to the CCU. A senior doctor in the ED reviewed
patients who were not admitted after 6 hours of observation.
A stress tetrofosmin nuclear scan was done . Patients were then admitted and discharged
depending on the results of the stress tetrofosmin scan.
Control group (conventional protocol)
Patients were then be admitted or discharged at the discretion of the senior ED doctor.
Measurement Patients were followed up at 1 week , 2 weeks , one month and six months for any
adverse cardiac events such as cardiac related death , ventricular fibrillation , and
Statistical analysis Logistic regression analysis were used to compare the proportion of
adverse events in the two treatment groups.
Feasibility and Diagnostic Accuracy of Myocardial Perfusion Imaging Using Early Imaging Protocol [Not yet recruiting]
The current protocol for myocardial perfusion imaging (MPI) entails imaging within 30-45
minutes after radiotracer injection, for both rest and stress studies. We hypothesize that
early imaging 10 minutes after radiotracer injection provides high image quality and
diagnostic accuracy comparable to 30-45 minutes MPI.
Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina. [Recruiting]
The WOMEN Study: What is the Optimal Method for Ischemia Evaluation in WomeN? [Active, not recruiting]
The purpose of this study is to compare two types of exercise stress testing to find the best
method for detecting heart disease in women.
Reports of Suspected Myoview (Tetrofosmin) Side Effects
Micturition Urgency (3),
Confusional State (2),
Chest Pain (2),
Respiratory Arrest (2),
Anaphylactic Reaction (1),
Aphasia (1), more >>