Physicians planning to use Gold Sodium Thiomalate should thoroughly familiarize themselves with its toxicity and its benefits. The possibility of toxic reactions should always be explained to the patient before starting therapy. Patients should be warned to report promptly any symptoms suggesting toxicity. Before each injection of Gold Sodium Thiomalate, the physician should review the results of laboratory work, and see the patient to determine the presence or absence of adverse reactions since some of these can be severe or even fatal.
MYOCHRYSINE® Gold Sodium Thiomalate is a sterile aqueous solution. It contains 0.5 percent BENZYL alcohol added as a preservative. The pH of the product is 5.8 t o 6.5. Gold Sodium Thiomalate is a mixture of the mono- and di- sodium salts of gold thiomalic acid.
Gold Sodium Thiomalate is indicated in the treatment of selected cases of active rheumatoid arthritisâboth adult and juvenile type. The greatest benefit occurs in the early active stage. In late stages of the illness when cartilage and bone damage have occurred, gold can only check the progression of rheumatoid arthritis and prevent further structural damage to joints. It cannot repair damage caused by previously active disease.
Gold Sodium Thiomalate should be used only as one part of a complete program of therapy; alone it is not a complete treatment.
Published Studies Related to Myochrysine (Gold Thiomalate)
Erythrocyte membrane gold levels after treatment with auranofin and sodium aurothiomalate. [2008.01]
Triethylphosphine gold-2,3,4,6-tetra-o-acetyl-L-thio-D-glucopyranoside (auranofin and sodium aurothiomalate; Myocrisin are two chemically different gold compounds used to treat rheumatoid arthritis. This study highlights the interaction, in vivo, of these drugs with erythrocyte membrane in patients with rheumatoid arthritis...
Gold sodium thiomalate for the treatment of rheumatoid arthritis in a patient with hepatitis B. [2011.04]
CONCLUSIONS: Gold sodium thiomalate proved to be a safe and effective treatment option in a patient with RA and hepatitis B.
Promiscuous interaction between gold-specific T cells and APCs in gold allergy. [2008.12.01]
Gold compounds clinically used as immunomodulators have high potential to evoke hypersensitivity reactions as an adverse effect. To explore the mechanism of gold allergy, we immunologically characterized T cells infiltrating skin rashes and generated 44 gold-specific T cell clones and lines from a rheumatoid arthritis patient who developed skin rashes and systemic symptoms after gold treatment...
Clinical pharmacology of gold. [2008.06]
Since the dawn of civilization, elemental gold and gold compounds have been revered and utilized by Shamen and medical practitioners alike for many varied pathological problems. In the 20(th) century following the observations of Jacques Forestier, injectable gold compounds were successfully used for the treatment of rheumatoid arthritis...
Aurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexes. [2008.06]
The aurocyanide anion, Au(CN) (2) (-) , is a human metabolite of several anti-rheumatic gold complexes containing monovalent gold (I) bound to a sulphur ligand. This article reviews some of the chemical and pharmacological properties of this intriguing metabolite, and reports its anti-arthritic and anti-inflammatory activity in rats...
Clinical Trials Related to Myochrysine (Gold Thiomalate)
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer [Withdrawn]
This phase I trial studies the side effects and best dose of sirolimus and gold sodium
thiomalate when given together in treating patients with advanced squamous non-small cell
lung cancer (NSCLC). Sirolimus and gold sodium thiomalate may stop the growth of tumor cells
by blocking some of the enzymes needed for cell growth
Gold Sodium Thiomalate in Treating Patients With Advanced Non-Small Cell Lung Cancer [Active, not recruiting]
RATIONALE: Gold sodium thiomalate may stop the growth of tumor cells by blocking some of the
enzymes needed for cell growth.
PURPOSE: This phase I trial is studying the side effects and best dose of gold sodium
thiomalate in treating patients with advanced non-small cell lung cancer.
Page last updated: 2011-12-09