Published Studies Related to Muse (Alprostadil)
[Clinical effects of alprostadil injection on acute kidney injury after cardiac surgical procedures]. [2010.08.24]
OBJECTIVE: To explore the clinical effects of alprostadil injection on acute kidney injury (AKI) after cardiac surgical procedures by a prospective randomized controlled trial... CONCLUSION: On the basis of routine therapy, alprostadil injection may promote the recovery of renal function in AKI-patients after cardiac surgical procedures.
Recovery of erectile function after nerve sparing radical prostatectomy and penile rehabilitation with nightly intraurethral alprostadil versus sildenafil citrate. [2010.06]
PURPOSE: To our knowledge we report the first large, randomized, prospective penile rehabilitation clinical trial to compare the effectiveness of nightly intraurethral alprostadil vs sildenafil citrate after nerve sparing prostatectomy... CONCLUSIONS: This is the first study to directly compare the ability of alprostadil and a phosphodiesterase-5 inhibitor to enhance penile recovery subsequent to bilateral nerve sparing radical prostatectomy. The use of nightly subtherapeutic intraurethral alprostadil is well tolerated after radical prostatectomy. The benefit to return of erectile function of nightly sildenafil citrate and subtherapeutic intraurethral alprostadil appears to be comparable within the first year of surgery. Copyright 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Long-term, multicenter study of the safety and efficacy of topical alprostadil cream in male patients with erectile dysfunction. [2009.02]
INTRODUCTION: Alprostadil is approved for treatment of male erectile dysfunction (ED) by injection or urethral insertion. Topical delivery of alprostadil offers an improved alternative. AIM: To evaluate the long-term safety and efficacy of topical alprostadil cream... CONCLUSIONS: Topical alprostadil cream was considered effective and safe by most patients and their partners, with most AEs limited to the application site. Dose adjustment to 300 mcg alprostadil facilitated the greatest improvement in erectile function in the majority of patients. A separate report will integrate patient data from the open-label extension and prior double-blind studies.
[Effects of alprostadil and ulinastatin on inflammatory response and lung injury after cardiopulmonary bypass in pediatric patients with congenital heart diseases] [2008.11.11]
OBJECTIVE: To investigate the therapeutic effects of alprostadil (Lipo-PGE1) and Ulinastatin on inflammatory response and lung injury after cardiopulmonary bypass (CPB) in pediatric patients with congenital heart diseases... CONCLUSION: Decreasing the inflammatory response after CPB, alprostadil and ulinastatin used during CPB effectively reduce the pulmonary injury via inhibition of the neutrophil activation and cytokines release.
Injection therapy for the treatment of erectile dysfunction: a comparison between alprostadil and a combination of vasoactive intestinal polypeptide and phentolamine mesilate. [2007.10]
OBJECTIVE: To compare two injectable treatments, alprostadil 5-20 microg powder for injection and a combination of vasoactive intestinal polypeptide (VIP) and phentolamine in patients with erectile dysfunction (ED)... CONCLUSIONS: VIP/phentolamine and alprostadil were effective treatments for ED, however the VIP/phentolamine combination was preferred by more patients, which may be because it was much less likely to cause pain.
Clinical Trials Related to Muse (Alprostadil)
The Use of Prostaglandin E1 in Head and Neck Microsurgery [Recruiting]
Prostaglandin E1 (PGE1 )has been shown to have vasodilatation and anti-thrombosis effects,
so it is used by some surgeons after microsurgery to keep the patency of the anastomosed
small vessels. However, PGE 1 may also causes some complications, like pleural effusion or
deep vein thrombosis. Therefore, it remains uncertain whether a routine use of PGE 1 after
head and neck microsurgery is justified. We aim to test the hypothesis that PGE 1 increases
postoperative vessel patency rate in patients undergoing head and neck microsurgery, with a
comparable complication rate as the control group.
Protective Effect of Lipo-PGE1 on Myocardial Injury Following Percutaneous Coronary Intervention [Not yet recruiting]
we hypothesized that periprocedural treatment with intravenous lipo-PGE1 may reduce
myocardial injury and improve clinical outcomes in patients undergoing PCI.
Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV [Recruiting]
The study is to confirmedly show a superior effect of Alprostadil compared to placebo on the
rate of complete healing of ischemic necroses and ulcerations.
Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF) [Not yet recruiting]
This is a randomized controlled trial (RCT) on the use of Inhaled prostaglandin E1 (IPGE1)
in Neonatal Hypoxemic Respiratory Failure (NHRF). Fifty patients recruited at 10 high
volume sites within the NICHD Neonatal Research Network will constitute a pilot sample to
evaluate the feasibility and safety of prolonged IPGE1 administration and determination of
optimal dose. In this Pilot RCT, two doses of IPGE1 (300 and 150 ng/kg/min) will be
administered over a maximum duration of 72 hours and compared with placebo. Once
feasibility and safety of IPGE1 administered over 72 hours has been demonstrated in the
pilot trial, a full scale randomized controlled trial will be planned.
Efficacy, Safety and Satisfaction of VITAROS (Transdermal Topical Alprostadil) in Men With Erectile Dysfunction [Not yet recruiting]
A Phase 4 clinical trial that is open, with no blinding of subjects or randomization of
treatment. Patients with erectile problems will be given the approved drug Vitaros to treat
their condition. They will be given forms and questionnaires to complete. The information
collected will be used to assess the effectiveness, safety and the satisfaction levels with
Reports of Suspected Muse (Alprostadil) Side Effects
Drug Ineffective (4),
Type 2 Diabetes Mellitus (3),
Wrong Technique in Drug Usage Process (2),
Penile Pain (2),
Anaphylactic Reaction (2),
Bladder Pain (2),
Urethral Pain (2),
Pubic Pain (2),
Urethral Haemorrhage (2), more >>