Mucomyst (Acetylcysteine Inhalation) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse effects have included stomatitis, nausea, vomiting, fever, rhinorrhea, drowsiness, clamminess, chest tightness, and bronchoconstriction. Clinically overt acetylcysteine induced bronchospasm occurs infrequently and unpredictably even in patients with asthmatic bronchitis or bronchitis complicating bronchial asthma.

Acquired sensitization to acetylcysteine has been reported rarely. Reports of sensitization in patients have not been confirmed by patch testing. Sensitization has been confirmed in several inhalation therapists who reported a history of dermal eruptions after frequent and extended exposure to acetylcysteine.

Reports of irritation to the tracheal and bronchial tracts have been received and although hemoptysis has occurred in patients receiving acetylcysteine such findings are not uncommon in patients with bronchopulmonary disease and a causal relationship has not been established.

ADVERSE REACTIONS

Oral administration of acetylcysteine, especially in the large doses needed to treat acetaminophen overdose, may result in nausea, vomiting and other gastrointestinal symptoms. Rash with or without mild fever has been observed rarely.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO MUCOMYST

Possible Mucomyst side effects / adverse reactions in 65 year old female

Reported by a pharmacist from France on 2007-03-02

Patient: 65 year old female weighing 50.0 kg (110.0 pounds)

Reactions: Dyspnoea, Asphyxia

Adverse event resulted in: hospitalization

Suspect drug(s):
Mucomyst

Other drugs received by patient: Atrovent; Bricanyl

Possible Mucomyst side effects / adverse reactions in 14 year old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2007-04-09

Patient: 14 year old female

Reactions: Pharyngeal Oedema, Pruritus, Urticaria

Suspect drug(s):
Aspirin
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Mucomyst
    Indication: Drug USE FOR Unknown Indication

Other drugs received by patient: Acetaminophen; Advil; Ethanol

Possible Mucomyst side effects / adverse reactions in 71 year old female

Reported by a physician from United States on 2007-10-11

Patient: 71 year old female weighing 70.8 kg (155.8 pounds)

Reactions: Fatigue, Visual Disturbance, Metabolic Encephalopathy, Hallucination, Somnolence, Eating Disorder, Lethargy

Adverse event resulted in: hospitalization

Suspect drug(s):
Digoxin
    Indication: Drug USE FOR Unknown Indication

Temodar
    Dosage: 75mgm2 per day
    Administration route: Oral
    Indication: Glioblastoma Multiforme
    Start date: 2007-08-06
    End date: 2007-09-17

Aspirin
    Indication: Drug USE FOR Unknown Indication

Decadron
    Indication: Drug USE FOR Unknown Indication

Duoneb
    Indication: Drug USE FOR Unknown Indication

Lasix
    Indication: Drug USE FOR Unknown Indication

Levaquin
    Indication: Drug USE FOR Unknown Indication

Mucomyst
    Indication: Drug USE FOR Unknown Indication

Radiation Therapy
    Dosage: 60gy cumulative dose
    Indication: Drug USE FOR Unknown Indication
    Start date: 2007-08-06
    End date: 2007-09-17

Other drugs received by patient: Colace; Lipitor; Lovenox; Metoprolol Tartrate