ADVERSE REACTIONS
The adverse reactions caused by morphine are essentially those observed with other opioid analgesics. They include the following major hazards: respiratory depression, apnea, and to a lesser degree, circulatory depression, respiratory arrest, shock, and cardiac arrest.
Most Frequently Observed
Constipation, lightheadedness, dizziness, sedation, nausea, vomiting, sweating, dysphoria, and euphoria.
Some of these effects seem to be more prominent in ambulatory patients and in those not experiencing severe pain. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down.
Less Frequently Observed Reactions
Central Nervous System: Weakness, headache, agitation, tremor, uncoordinated muscle movements, seizure, alterations of mood (nervousness, apprehension, depression, floating feelings), dreams, muscle rigidity, transient hallucinations and disorientation, visual disturbances, insomnia, increased intracranial pressure
Gastrointestinal: Dry mouth, biliary tract spasm, laryngospasm, anorexia, diarrhea, cramps, taste alteration, constipation, ileus, intestinal obstruction, dyspepsia, increases in hepatic enzymes
Cardiovascular: Flushing of the face, chills, tachycardia, bradycardia, palpitation, faintness, syncope, hypotension, hypertension
Genitourinary: Urine retention or hesitance, amenorrhea, reduced libido and/or potency
Dermatologic: Pruritus, urticaria, other skin rashes, edema, diaphoresis
Other: Antidiuretic effect, paresthesia, bronchospasm, muscle tremor, blurred vision, nystagmus, diplopia, miosis, anaphylaxis
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REPORTS OF SUSPECTED MS CONTIN SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to MS Contin. The information is not vetted and should not be considered as verified clinical evidence.
Possible MS Contin side effects / adverse reactions in 37 year old female
Reported by a pharmacist from United Kingdom on 2011-10-05
Patient: 37 year old female
Reactions: Drug Ineffective, Maternal Exposure During Pregnancy, Stillbirth
Suspect drug(s):
Feverall
Dosage: 1 gm
Indication: Symphysiolysis
Buprenorphine
Dosage: 10 mcg;qg;tder
Indication: Symphysiolysis
Start date: 2010-12-15
End date: 2010-12-29
Acetaminophen W/ Codeine
Dosage: po
Administration route: Oral
Indication: Symphysiolysis
MS Contin
Dosage: 5 mg;bid;po
Administration route: Oral
Indication: Symphysiolysis
Start date: 2010-09-22
Other drugs received by patient: Citalopram
Possible MS Contin side effects / adverse reactions in 37 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-06
Patient: 37 year old female
Reactions: Drug Ineffective, Intra-Uterine Death, Maternal Exposure During Pregnancy, Abortion Spontaneous
Suspect drug(s):
Buprenorphine
Dosage: 10 ug, one hours
Indication: Symphysiolysis
Start date: 2010-12-15
End date: 2010-12-29
MS Contin
Dosage: 5 mg
Administration route: Oral
Start date: 2010-09-22
Acetaminophen
Dosage: 10 mg, per hour
Acetaminophen and Codeine Phosphate
Dosage: 1 g,
Administration route: Oral
Other drugs received by patient: Citalopram Hydrobromide
Possible MS Contin side effects / adverse reactions in 37 year old female
Reported by a pharmacist from United Kingdom on 2011-10-07
Patient: 37 year old female
Reactions: Drug Ineffective, Stillbirth, Maternal Exposure During Pregnancy
Suspect drug(s):
Acetaminophen
Dosage: 1 g
Indication: Symphysiolysis
MS Contin
Administration route: Oral
Indication: Symphysiolysis
Start date: 2010-09-22
Acetaminophen and Codeine Phosphate
Administration route: Oral
Indication: Symphysiolysis
Butrans
Indication: Symphysiolysis
Start date: 2010-12-15
End date: 2010-12-29
Other drugs received by patient: Citalopram Hydrobromide
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