ADVERSE REACTIONS
The adverse reactions caused by morphine are essentially those observed with other opioid analgesics. They include the following major hazards: respiratory depression, apnea, and to a lesser degree, circulatory depression, respiratory arrest, shock, and cardiac arrest.
Most Frequently Observed
Constipation, lightheadedness, dizziness, sedation, nausea, vomiting, sweating, dysphoria, and euphoria.
Some of these effects seem to be more prominent in ambulatory patients and in those not experiencing severe pain. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down.
Less Frequently Observed Reactions
Central Nervous System: Weakness, headache, agitation, tremor, uncoordinated muscle movements, seizure, alterations of mood (nervousness, apprehension, depression, floating feelings), dreams, muscle rigidity, transient hallucinations and disorientation, visual disturbances, insomnia, increased intracranial pressure
Gastrointestinal: Dry mouth, biliary tract spasm, laryngospasm, anorexia, diarrhea, cramps, taste alteration, constipation, ileus, intestinal obstruction, dyspepsia, increases in hepatic enzymes
Cardiovascular: Flushing of the face, chills, tachycardia, bradycardia, palpitation, faintness, syncope, hypotension, hypertension
Genitourinary: Urine retention or hesitance, amenorrhea, reduced libido and/or potency
Dermatologic: Pruritus, urticaria, other skin rashes, edema, diaphoresis
Other: Antidiuretic effect, paresthesia, bronchospasm, muscle tremor, blurred vision, nystagmus, diplopia, miosis, anaphylaxis
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO MS CONTIN
Below is a sample of reports where side effects / adverse reactions may be related to MS Contin. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible MS Contin side effects / adverse reactions in 52 year old female
Reported by a individual with unspecified qualification from United States on 2007-01-16
Patient: 52 year old female weighing 63.0 kg (138.6 pounds)
Reactions: Weight Decreased, Abdominal Pain, Asthma, Pyrexia, Loss of Consciousness, Injection Site Erythema, Pneumonia, Drug Abuser, Injection Site Bruising, Drug Withdrawal Syndrome, Delirium, Tremor, Paraesthesia, Respiratory Tract Congestion, Anorexia, Dehydration, Vision Blurred, Disturbance in Attention, Pain, Injection Site Swelling, Disorientation, Somnolence, Speech Disorder, Myalgia, RED Blood Cell Count Decreased, Injection Site Reaction, Dizziness, Depression, Vomiting, Nausea, Dental Caries, Burning Sensation, Diarrhoea, Blood Potassium Decreased, Alopecia, Bronchitis, Memory Impairment, Asthenia
Adverse event resulted in: hospitalization
Suspect drug(s):
MS Contin
Dosage: unk, unk
Indication: Drug USE FOR Unknown Indication
End date: 2005-10-01
MS Contin
Start date: 2005-01-01
MS Contin
End date: 2005-09-25
PEG-Intron
Dosage: unk, unk
Indication: Hepatitis C
Start date: 2005-09-25
Ribasphere
Administration route: Oral
Indication: Hepatitis C
Start date: 2005-09-25
Other drugs received by patient: Aspirin; Buspar; Calcium; Glucosamine W/chondroitin Sulfates; Hydromorphone HCL; Inderal; Lecithin; Levothyroxine Sodium; Morphine Sulfate; Vitamin CAP; Omega-3; Promethazine; Vitamin A and D; Vitamin B Complex CAP; Ascorbic Acid; Vitamin E; Wellbutrin; Morphine Sulfate; Flaxseed OIL; Calcium; Albuterol; Epogen; Iron; Inderal; Doxycycline Hydrochloride
Possible MS Contin side effects / adverse reactions in 52 year old female
Reported by a individual with unspecified qualification on 2007-01-18
Patient: 52 year old female weighing 63.0 kg (138.6 pounds)
Reactions: Weight Decreased, Asthma, Abdominal Pain, Pyrexia, Loss of Consciousness, Pneumonia, Drug Abuser, Drug Withdrawal Syndrome, Delirium, Tremor, Paraesthesia, Dehydration, Anorexia, Disturbance in Attention, Vision Blurred, Pain, Disorientation, Somnolence, Speech Disorder, Myalgia, RED Blood Cell Count Decreased, Injection Site Reaction, Dizziness, Depression, Vomiting, Nausea, Dental Caries, Blood Potassium Decreased, Diarrhoea, Alopecia, Bronchitis, Memory Impairment, Asthenia
Adverse event resulted in: hospitalization
Suspect drug(s):
MS Contin
Dosage: unk, unk
Indication: Drug USE FOR Unknown Indication
Start date: 2005-09-25
PEG-Intron
Dosage: unk, unk
Indication: Hepatitis C
Start date: 2005-09-25
Ribasphere
Dosage: unk, unk
Indication: Hepatitis C
Start date: 2005-09-25
Other drugs received by patient: Aspirin; Buspar; Calcium; Glucosamine W/chondroitin Sulfates; Hydromorphone HCL; Lecithin; Levothyroxine Sodium; Vitamin CAP; Omega-3; Promethazine; Vitamin A+D; Vitamin B Complex CAP; Ascorbic Acid; Vitamin E; Wellbutrin; Albuterol Sulate; Flaxseed OIL; Inderal; Epogen; Iron
Possible MS Contin side effects / adverse reactions in 47 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2007-02-21
Patient: 47 year old female weighing 52.2 kg (114.8 pounds)
Reactions: Phlebitis, Muscle Atrophy, Pain, Post Procedural Complication, Condition Aggravated, Appendicitis Perforated, Gangrene, Collapse of Lung, Haematotoxicity, Peritonitis, Complex Regional Pain Syndrome, Joint Sprain, Pleural Effusion
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Lotrel
Dosage: 1 tab daily po
Administration route: Oral
Indication: Hypertension
Start date: 2001-01-01
End date: 2007-02-20
MS Contin
Dosage: 1 tablet twice daily-bid- po
Administration route: Oral
Indication: Complex Regional Pain Syndrome
Start date: 2000-08-20
End date: 2007-02-20
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