MS CONTIN contains morphine sulfate, an opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics.
Morphine can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing MS CONTIN in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.
MS CONTIN Tablets are a controlled-release oral formulation of morphine sulfate indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.
MS CONTIN Tablets are NOT intended for use as a prn analgesic.
MS CONTIN 100 and 200 mg Tablets ARE FOR USE IN OPIOID-TOLERANT PATIENTS ONLY. These tablet strengths may cause fatal respiratory depression when administered to patients not previously exposed to opioids.
MS CONTIN TABLETS ARE TO BE SWALLOWED WHOLE AND ARE NOT TO BE BROKEN, CHEWED, DISSOLVED, OR CRUSHED. TAKING BROKEN, CHEWED, DISSOLVED, OR CRUSHED MS CONTIN TABLETS LEADS TO RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE OF MORPHINE.
MS CONTIN SUMMARY
MS CONTIN (morphine sulfate) is an opioid analgesic.
MS CONTIN is a controlled-release oral morphine formulation indicated for the relief of moderate to severe pain. It is intended for use in patients who require repeated dosing with potent opioid analgesics over periods of more than a few days.
The MS CONTIN 200 mg tablet strength is a high dose, controlled-release, oral morphine formulation indicated for the relief of pain in opioid-tolerant patients only.
Media Articles Related to MS Contin (Morphine)
CDC: low awareness among women of birth defect risk from opioids
Source: Pregnancy / Obstetrics News From Medical News Today [2015.01.23]
Many women may be unaware that prescription opioid-based painkillers such as codeine, oxycodone, hydrocodone or morphine may increase the risk for birth defects.
Lethal Injection: A Cruel, Painful, Terrifying Execution
Source: MedPageToday.com - medical news plus CME for physicians [2015.01.24]
(MedPage Today) -- The U.S. Supreme Court said Friday that it would hear arguments in a case challenging lethal injections used in state executions. In response MedPage Today is republishing this article, which was originally published May 2, 2014.
Mode of delivery in childbirth associated with pain during or after sexual intercourse
Source: Nursing / Midwifery News From Medical News Today [2015.01.23]
Operative birth is associated with persisting pain during or after sexual intercourse, known as dyspareunia, suggests a new study published in BJOG: An International Journal of Obstetrics and...
Lower Back Pain
Source: MedicineNet Abdominal Aortic Aneurysm Specialty [2015.01.23]
Title: Lower Back Pain
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 1/23/2015 12:00:00 AM
Many Women of Childbearing Age Take Narcotic Painkillers: CDC
Source: MedicineNet Birth Defects Specialty [2015.01.23]
Title: Many Women of Childbearing Age Take Narcotic Painkillers: CDC
Category: Health News
Created: 1/22/2015 12:00:00 AM
Last Editorial Review: 1/23/2015 12:00:00 AM
Published Studies Related to MS Contin (Morphine)
Evaluation of a single-dose, extended-release epidural morphine formulation for
pain control after lumbar spine surgery. 
DepoDur, an extended-release epidural morphine, has been used effectively for
postoperative pain control following many orthopaedic and general surgery
procedures and has provided prolonged analgesia when compared with Duramorph. The
goal of this article was to compare the safety and analgesic efficacy of DepoDur
versus Duramorph after lumbar spine surgery...
Morphine decreases clopidogrel concentrations and effects: a randomized,
double-blind, placebo-controlled trial. 
effects on platelets... CONCLUSIONS: Morphine delays clopidogrel absorption, decreases plasma levels of
The postoperative analgesic effect of morphine and paracetamol in the patients
undergoing laparotomy, using PCA method. 
CONCLUSION: Morphine seems to be more effective at 2 and 4 hours, but after 4
Comparison of the efficacy and safety of dual-opioid treatment with morphine plus
oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after
total knee arthroplasty. 
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose
Effect of morphine on lower urinary tract discomfort after transurethral
resection of prostate under general anesthesia: a randomised clinical study. 
TURP-related LUT discomfort symptoms... CONCLUSION: Based on these results, we conclude that morphine effectively reduces
Clinical Trials Related to MS Contin (Morphine)
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety
of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate
release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain
following third molar extraction.
Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain
relief and side effect profiles of same in the setting of Total Knee Replacement. We
hypothesized that a dose greater than that used in Total Hip Replacement was needed and
wished to find a dose which was effective but had a low side effect profile.
Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray
(MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo
in patients with moderate to severe post-surgical pain following orthopedic surgery. After
initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24)
hours will be evaluated. The rescue dose remained the same for each.
A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for
treating moderate to severe chronic pain over a 12 week period.
INFUSE Morphine Study [Completed]
Double-blind study comparing the pharmacokinetics, safety and tolerability of morphine
administered subcutaneously (SC) with and without human recombinant hyaluronidase (HYLENEX)
and intravenously conducted in patients in a hospice care setting or through a palliative
care medicine setting. In this within-patient controlled study, each eligible study patient
receives a single injection by each of the three methods of morphine administration,
sequentially on three consecutive days, according to the order specified by a randomization
Each of the three injections consists of 5 mg of morphine (1. 0 mL of 5 mg/mL solution). The
HYLENEX injection will be 1 mL of 150 units. Although the IV administration will not be
blinded, the two SC injections will be double-blinded, using the same volume of normal saline
(0. 9% sodium chloride) placebo (1. 0 mL) as HYLENEX.
Reports of Suspected MS Contin (Morphine) Side Effects
Confusional State (15),
Weight Decreased (12),
Drug Ineffective (12),
Renal Failure Acute (12),
Drug Abuse (11), more >>
Page last updated: 2015-01-24