Motrin (Ibuprofen) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

In patients taking MOTRIN or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1-10% of patients are: Abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, fluid retention, gastrointestinal experiences (including abdominal pain, bloating, constipation, diarrhea, dyspepsia, epigastric pain, flatulence, heartburn, nausea, vomiting), headaches, increased bleeding time, nervousness, pruritus, rashes (including maculopapular) and tinnitus.

Additional adverse experiences reported occasionally include:
Body as a whole -	fever, infection, sepsis
Cardiovascular system -	congestive heart failure in patients with marginal cardiac function, hypertension, tachycardia, syncope
Digestive system -	dry mouth, duodenitits, esophagitis, gastric or duodenal ulcer with bleeding and/or perforation, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice, melena, rectal bleeding
Hemic and lymphatic system -	ecchymosis, eosinophilia, leukopenia, purpura, stomatitis, thrombocytopenia
Metabolic and nutritional -	weight changes
Nervous system -	anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, paresthesia, somnolence, tremors, vertigo
Respiratory system -	asthma, dyspnea
Skin and appendages -	alopecia, photosensitivity, sweat
Special senses -	blurred vision
Urogenital system -	cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, acute renal failure in patients with pre-existing significantly impaired renal function
Other adverse reactions, which occur rarely are:
Body as a whole -	anaphylactic reactions, anaphylactoid reactions, appetite changes,
Cardiovascular system -	arrhythmia, cerebrovascular accident, hypotension, myocardial infarction, palpitations, vasculitis
Digestive system -	eructation, gingival ulcer, hepatorenal syndrome, liver necrosis, liver failure, pancreatitis
Hemic and lymphatic system -	agranulocystosis, hemolytic anemia, aplastic anemia, lymphadenopathy, neutropenia, pancytopenia
Metabolic and nutritional -	hyperglycemia
Nervous system -	convulsions, coma, emotional lability, hallucinations, aseptic meningitis
Respiratory -	apnea, respiratory depression, pneumonia, rhinitis
Skin and appendages -	angioedema, toxic epidermal necrosis, erythema multiforme, exfoliative dermatitis, Stevens Johnson syndrome, urticaria, vesiculobullous eruptions
Special senses -	amblyopia (blurred and/or diminished vision, scotomata and/or changes in color vision), conjunctivitis, dry eyes, hearing impairment
Urogenital-	azotemia, decreased creatinine clearance, glomerulitis, renal papillary necrosis, tubular necrosis

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO MOTRIN

Possible Motrin side effects / adverse reactions in 73 year old female

Reported by a physician from United States on 2007-01-19

Patient: 73 year old female

Reactions: Gastrointestinal Haemorrhage, Pain, Dyspnoea Exertional, Haematocrit Decreased, Fatigue, Iron Deficiency Anaemia, Pulmonary Oedema, Muscle Spasms, Hiatus Hernia, Stomach Discomfort, Occult Blood Positive, Haemoglobin Decreased, Syncope, Diverticulum, Ventricular Tachycardia, Suicide Attempt, Asthenia, Depressed Mood

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Aleve
    Dosage: total daily dose: 880 mg unit dose: 220 mg
    Administration route: Oral
    Indication: Arthralgia

Motrin
    Dosage: total daily dose: 2400 mg unit dose: 800 mg
    Indication: Osteoarthritis

Naprosyn
    Indication: Osteoarthritis

Possible Motrin side effects / adverse reactions in 49 year old male

Reported by a pharmacist from United States on 2007-01-22

Patient: 49 year old male weighing 105.0 kg (231.0 pounds)

Reactions: Renal Failure Acute

Adverse event resulted in: hospitalization

Suspect drug(s):
Salsalate 750mg
    Dosage: 750mg q8 h prn po
    Administration route: Oral
    Indication: Back Pain
    Start date: 2006-08-21

Motrin
    Dosage: 800mg prn po
    Administration route: Oral
    Indication: Pain

ASA 81 MG Daily PO
    Dosage: 81mg daily po
    Administration route: Oral
    Start date: 2006-06-04

Possible Motrin side effects / adverse reactions in 40 year old female

Reported by a pharmacist from United States on 2007-02-01

Patient: 40 year old female weighing 65.0 kg (143.0 pounds)

Reactions: Vomiting, Medication Error, Nausea, Incorrect Dose Administered, Abdominal Pain Upper, Haematemesis

Adverse event resulted in: life threatening event

Suspect drug(s):
Motrin
    Indication: Toothache
    Start date: 2007-01-12
    End date: 2007-01-26

Tylenol
    Indication: Toothache
    Start date: 2007-01-12
    End date: 2007-01-26