DESCRIPTION
The active ingredient in MOTRIN is ibuprofen, which is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. It is a white to off-white crystalline powder, with a melting point of 74° to 77°C. It is practically insoluble in water (<0.1 mg/mL), but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid. The molecular weight of ibuprofen is 206.28. Its molecular formula is C13H18O2 and it has the following structural formula:
MOTRIN Suspension is a sucrose-sweetened, orange-colored, berry-flavored liquid suspension containing 100 mg of ibuprofen in 5 mL (20 mg/mL). Inactive ingredients include citric acid, glycerin, polysorbate 80, pregelatinized starch, purified water, sodium benzoate, sucrose, xanthan gum, D&C Yellow #10 and FD&C Red #40, and artificial flavors. MOTRIN Oral Drops (intended for pediatric use only) is a sucrose-sweetened, pink-colored, berry-flavored liquid suspension containing 40 mg of ibuprofen per mL. Inactive ingredients include citric acid, glycerin, polysorbate 80, pregelatinized starch, purified water, sodium benzoate, sorbitol, sucrose, xanthan gum, FD&C Red #40, and artificial flavors. MOTRIN Chewable Tablets are aspartame-sweetened, citrus-tasting, orange-colored tablets, that contain 50 mg or 100 mg of ibuprofen per tablet. Inactive ingredients include aspartame, citric acid, hydroxyethyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, mannitol, microcrystalline cellulose, povidone, sodium lauryl sulfate, sodium starch glycolate, FD&C Yellow #6, and artificial flavors. MOTRIN Caplets are unsweetened, white-colored, unflavored, film-coated, capsule-shaped tablets, containing 100 mg of ibuprofen per tablet. Inactive ingredients include carnauba wax, colloidal silicone dioxide, cornstarch, hydroxypropyl methylcellulose, microcrystalline cellulose, polydextrose, polyethylene glycol, pregelatinized starch, propylene glycol, sodium starch glycolate, titanium dioxide, triacetin, D&C Yellow #10, and FD&C Yellow #6.
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