Motrin (Ibuprofen) - Summary

MOTRIN SUMMARY

MOTRIN® (ibuprofen) Suspension 100 mg/5 mL

The active ingredient in MOTRIN is ibuprofen, which is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. It is a white to off-white crystalline powder, with a melting point of 74° to 77°C. It is practically insoluble in water (<0.1 mg/mL), but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid.

In Children   MOTRIN is indicated:

• For reduction of fever in patients aged 6 months and older.
• For relief of mild to moderate pain in patients aged 6 months and older.
• For relief of signs and symptoms of juvenile arthritis.

In Adults   MOTRIN is indicated:

• For relief of mild to moderate pain.
• For treatment of primary dysmenorrhea.
• For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.

Since there have been no controlled trials to demonstrate whether there is any beneficial effect or harmful interaction with the use of ibuprofen in conjuction with aspirin, the combination cannot be recommended (see PRECAUTIONS -- Drug Interactions).

See all indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Motrin (Ibuprofen)

Tylenol, Motrin, Benadryl, St. Joseph Aspirin, Rolaids Recall
Source: MedicineNet Abdominal Pain Specialty [2010.01.15]
Title: Tylenol, Motrin, Benadryl, St. Joseph Aspirin, Rolaids Recall
Category: Health News
Created: 1/15/2010 2:05:00 PM
Last Editorial Review: 1/15/2010 2:05:42 PM

Wyeth Consumer Healthcare Withdraws Its Marketing Authorisation Application For Ibuprofen/Diphenhydramine Hydrochloride Wyeth
Source: Sleep / Sleep Disorders / Insomnia News From Medical News Today [2010.01.17]
The European Medicines Agency has been formally notified by Wyeth Consumer Healthcare of its decision to withdraw its application for a centralised marketing authorisation for the medicine Ibuprofen/Diphenhydramine Hydrochloride Wyeth 200 mg/25 mg soft capsules...

Caldolor Is First Approved Injected Ibuprofen
Source: MedicineNet Hysterectomy Specialty [2009.06.15]
Title: Caldolor Is First Approved Injected Ibuprofen
Category: Health News
Created: 6/13/2009 7:00:00 AM
Last Editorial Review: 6/15/2009

NSAIDs may beat acetaminophen for menstrual cramps (Reuters)
Source: Y! Health HIV & AIDS News [2010.01.26]
Reuters - The class of painkillers that includes ibuprofen and naproxen seems to work well against menstrual cramps, and may be more effective than acetaminophen, a new research review suggests.

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Published Studies Related to Motrin (Ibuprofen)

A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. [2009.10]
STUDY OBJECTIVE: We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)... CONCLUSION: Ibuprofen was at least as effective as acetaminophen with codeine for outpatient analgesia for children with arm fractures. There was no significant difference in analgesic failure or pain scores, but children receiving ibuprofen had better functional outcomes. Children receiving ibuprofen had significantly fewer adverse effects, and both children and parents were more satisfied with ibuprofen. Ibuprofen is preferable to acetaminophen with codeine for outpatient treatment of children with uncomplicated arm fractures.

Ascorbic acid combined with ibuprofen in hypoxic ischemic encephalopathy: a randomized controlled trial. [2009.06]
OBJECTIVE: Free oxygen radicals and proinflammatory cytokines are important causes for brain injury in neonates with hypoxic ischemic encephalopathy (HIE). Our objectives were to test the hypothesis that a combination of antioxidants (ascorbic acid) and anti-inflammatory agents (ibuprofen) can ameliorate the brain injury in HIE and improve neurodevelopmental outcomes when given to term infants immediately after birth... CONCLUSION: Early administration of ascorbic acid and ibuprofen did not affect outcomes in infants with perinatal asphyxia. This study does not explain whether our intervention was not effective in blocking free radicals and inflammatory cytokines, if the dosing and route of administration were inadequate, or if other mediators existed that could have a more powerful role in brain injury during hypoxia-ischemia.

Comparison of the analgesic effect of ibuprofen with mesalamine after discectomy surgery in patients with lumbar disc herniation: a double-blind randomized controlled trial. [2009.05]
BACKGROUND: Pain management is an important component in the postoperative period following discectomy. AIMS: We hypothesized that mesalamine considering its better safety profile, is likely to be a better choice, if it would be as effective as ibuprofen in controlling post-discectomy pain. SETTINGS AND DESIGN: A double-blind randomized controlled trial was performed on patients who underwent lumbar discectomy surgery... CONCLUSIONS: Since both drugs showed almost equal analgesic effect, considering its safety profile mesalamine, seems to be the preferred choice to alleviate post-discectomy surgery pain.

Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial. [2009.05]
OBJECTIVES: To establish the relative clinical effectiveness and cost-effectiveness of paracetamol plus ibuprofen compared with paracetamol and ibuprofen separately for time without fever, and the relief of fever-associated discomfort in young children who can be managed at home... CONCLUSIONS: Young children who are unwell with fever should be treated with ibuprofen first, but the relative risks (inadvertently exceeding the maximum recommended dose) and benefits (extra 2.5 hours without fever) of using paracetamol plus ibuprofen over 24 hours should be considered. However, if two medicines are used, it is recommended that all dose times are carefully recorded to avoid accidentally exceeding the maximum recommended dose. Manufacturers should consider supplying blank charts for this purpose. Use of both medicines should not be discouraged on the basis of cost to either parents or the NHS. Parents and clinicians should be aware that fever is a relatively short-lived symptom, but may have more serious prognostic implications than the other common symptom presentations of childhood.

A randomized, placebo-controlled, exploratory trial of Ibuprofen and pseudoephedrine in the treatment of primary nocturnal enuresis in children. [2009.05]
This exploratory randomized, double-blind, double-dummy, placebo-controlled trial of 14 days duration conducted in 22 primary care practices in the United States was used to compare the efficacy of ibuprofen and pseudoephedrine, administered alone or in combination, to placebo for the treatment of primary nocturnal enuresis (PNE) in children aged 6 to 11 years...

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Clinical Trials Related to Motrin (Ibuprofen)

Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants [Completed]
it is a prospective randomized simple-blinded pilot trial with the principal aim to compare efficacy and tolerance between oral ibuprofen and intravenous ibuprofen in early curative closure of PDA in very low birth weight infants. The likelihood of ductal closure with only one or two doses of treatment is a secondary objective.

Ibuprofen-PC Compared With Ibuprofen in a GI Safety Trial [Active, not recruiting]

Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-Associated Ulcers [Active, not recruiting]
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.

Celecoxib, Ibuprofen and the Antiplatelet Effect of Aspirin [Completed]
Study design: Single center, placebo-controlled, double blind, parallel groups. To evaluate the potential interaction between aspirin and ibuprofen or celecoxib in patients with osteoarthritis (OA) and documented stable ischemic heart disease, a total of 24 patients chronically treated with aspirin will be randomly assigned to one of the 3 treatment groups: 1) celecoxib 200 mg bid; 2) ibuprofen 600 mg tid; 3) placebo.

Treatment of Fever Due to Malaria With Ibuprofen [Completed]
Drugs to treat fever are widely used in children with fever. But there is a controversy about the benefit of reducing fever in children with malaria. Ibuprofen is often used to treat malarial fever. This study evaluates the capacity of ibuprofen to reduce fever in malaria. The effect of ibuprofen on fever compared to only mechanical measures is investigated in children with malaria.

more trials >>

PATIENT REVIEWS / RATINGS / COMMENTS

Motrin review by 21 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		menstrual cramps
Dosage & duration:		2 tablets a day- morning and night taken twice a day. in the morning and night for the period of 34 days every month
Other conditions:		Ihave sinus but the pill does not have any side effects so it is advisable to take it to control men
Other drugs taken:		nothing else
		Reported Results
Benefits:		I was relieved of menstrual cramps within 15 minutes of taking the pill and during nighttime i was able to sleep peacefully without any pain.I was able to carry out my routine work
Side effects:		There are absolutely no side effects
Comments:		it is advisable to take the tablet after breakfast and after dinner so that makes it twice a day but only for 4 days

Motrin review by 58 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		arthritis pain, neck injury
Dosage & duration:		800mg taken three times a day for the period of daily
Other conditions:		hypertension
Other drugs taken:		baclofen
		Reported Results
Benefits:		decreased pain and inflamation, need no other pain medication for arthritis pain, have bee taking motrin for eight years with good results and little side effects other than mild nausea when taken without food.
Side effects:		motrin has caused mild nausea when taken without food and or milk. when taken after meals it did not cause any nausea, i have not noticed any other side effect.
Comments:		take motrin 800mg, 1 three times a day as needed for arthritis pain

Motrin review by 38 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		flu
Dosage & duration:		max daily dose on packet (dosage frequency: each day) for the period of 3 days
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		significant reduction of pain due to the flu virus. this is a typical prescription for the flu, pain killers with lots of fluids. I was drawn to this tablets because they look appealing, the red capsules are easy to take and the caplets are coated in sugar. Normally I'd take paracetamol, which are dry and hard to swallow, I choose these to be kind to myself !!! I had no idea they could cause this reaction. they were good pain killers.
Side effects:		asthmatic condition. Heavy chest, dry cough, weakness, cumulative effect over days. Still prone to shortness of breath and tightness and heavy chest feelings, very sensitive to sulphides in wine and vinegars etc, was not before this. I only became aware of this connection when I took some I had left for a period pain, once again within seconds I was really ill.
Comments:		Not sure what this section requires ? It's a straight forward case of pain relief in response to the flu virus. the symptoms and the side effects became inter-twined, so it was not apparent that this drug was causing a reaction and worse than that I continued taking it as I became more and more ill. This is an over the counter drug, I would have appreciated more information from my pharmacist. I have tried to tell as many people as possible about what happened. After I have stopped taking the treatment I am left with a susceptibility to asthmatic type symptoms, it was also scary as I instinctively knew I was getting worse and became concerned something very serious was going on. I have never experience that type of "illness" before, normally I take time out and get well... this was an eye-opener.