- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS).
- MOTRIN Suspension is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).
MOTRIN® (ibuprofen) Suspension 100 mg/5 mL
The active ingredient in MOTRIN is ibuprofen, which is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. It is a white to off-white crystalline powder, with a melting point of 74° to 77°C. It is practically insoluble in water (<0.1 mg/mL), but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid.
In Children MOTRIN is indicated:
For reduction of fever in patients aged 6 months and older.
For relief of mild to moderate pain in patients aged 6 months and older.
For relief of signs and symptoms of juvenile arthritis.
In Adults MOTRIN is indicated:
For relief of mild to moderate pain.
For treatment of primary dysmenorrhea.
For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.
Since there have been no controlled trials to demonstrate whether there is any beneficial effect or harmful interaction with the use of ibuprofen in conjuction with aspirin, the combination cannot be recommended (see PRECAUTIONS -- Drug Interactions).
Published Studies Related to Motrin (Ibuprofen)
Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. 
CONCLUSIONS: The combination of ibuprofen 400 mg plus codeine 25.6 mg to
Intramuscular ketorolac versus oral ibuprofen for pain relief in first-trimester
surgical abortion: a randomized clinical trial. 
ketorolac for pain management during first-trimester surgical abortion... CONCLUSIONS: Intramuscular ketorolac does not offer superior pain control
Randomized clinical trial evaluating transdermal Ibuprofen for moderate to severe
knee osteoarthritis. 
pain management practices... CONCLUSIONS: The use of transdermal VALE-ibuprofen has beneficial clinical
Diclofenac with or without an antiemetic for acute migraine headaches in adults. 
CONCLUSIONS: Oral diclofenac potassium 50 mg is an effective treatment
Randomized comparison between the combination of acetaminophen and ibuprofen and
each constituent alone for analgesia following tonsillectomy in children. 
individual constituents for analgesia following tonsillectomy in children... CONCLUSION: The combination of ibuprofen and acetaminophen was not superior to
Clinical Trials Related to Motrin (Ibuprofen)
Efficacy Study of IV Ibuprofen vs IV Acetaminophen Post Surgical Extraction [Recruiting]
This study will compare how effective a single dose of an intravenous (IV) ibuprofen is when
compared to single dose of IV acetaminophen in reducing pain. We will administer this study
medication thirty minutes prior to removal of wisdom teeth. We want to see if administering
these drugs prior to surgery may reduce post-operative pain.
Administration of nonsteroidal anti-inflammatory drug before the onset of inflammation
during surgery will reduce postoperative pain following third molar extraction when compared
to the acetaminophen group. Subjects receiving nonsteroidal anti-inflammatory drug will
consume less opioid medications compared to those receiving preemptive acetaminophen.
Oral Ibuprofen Prophylaxis for Patent Ductus Arterioses in Very Extremely Low Birth Weight Infants [Recruiting]
Patent ductus arterioses (PDA) is a major morbidity in preterm infants, especially in
extremely premature infants less than 28 weeks. The clinical signs and symptoms of PDA in
preterm infants are non specific and insensitive for making an early diagnosis of
significant ductal shunting. Functional echocardiography is emerging as a new valuable
bedside tool for early diagnosis of hemodynamically significant ductus, even though there
are no universally accepted criteria for grading the hemodynamic significance.
Echocardiography has also been used for early targeted treatment of ductus arterioses,
though the long term benefits of such strategy are debatable. The biomarkers like BNP and N-
terminal pro-BNP are currently under research as diagnostic marker of PDA. The primary mode
of treatment for PDA is pharmacological closure using cyclo-oxygenase inhibitors with
closure rate of 70-80%. Oral ibuprofen is emerging as a better alternative especially in
Indian scenario where parenteral preparations of indomethacin are unavailable and side
effects are comparatively lesser. Though pharmacological closure of PDA is an established
treatment modality, there is still lack of evidence for long term benefits of such therapy
as well as there is some evidence for the possible adverse effects like increased ROP and
BPD rates, especially if treated prophylactically. The aim of this study is to investigate
the effect of oral ibuprofen prophylaxis administrated on the first 24 hours of life and the
following two days on hemodynamically significant patent ductus arterioses and its long term
effects such as ROP and BPD.
Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production [Completed]
The purpose of this study is to determine whether paracetamol, ibuprofen or their
combination can modify generation of radical oxygen species (ROS) from stimulated
Early Versus Late Use of Ibuprofen for PDA Closure [Terminated]
The primary objective is to evaluate the PDA closure rate of early vs. late use of Ibuprofen
(Ibu). The investigators believe that early use of Ibu will have a higher PDA closure rate
than later use of Ibu. Early use is defined as medication given before the infant reaches
96 hrs old. Late use is defined as medication given when infant is more than 96 hrs old.
The secondary objective is to measure the stress hormone and metabolic response (plasma
catecholamines, glucose, and lactate) of neonates undergoing Ibu treatment of the PDA. The
investigators believe that early ibuprofen will blunt the stress response greater than later
Safety Study of Ibuprofen to Treat Acute Traumatic Spinal Cord Injury [Recruiting]
The Ibuprofen - Spinal Cord Injury (SCI) - Safety trial investigates tolerability and
feasibility of "small molecule" (Ibuprofen) mediated Rho-inhibition as putative
neuroprotective, plasticity-enhancing and neurorestaurative intervention. The primary safety
analysis is based on the incidence of severe gastrointestinal bleedings. In addition, the
feasibility of recruitment procedure, and oral administration of the compound within the
multidisciplinary setting of acute intensive medical care will be explored. Furthermore, the
pharmacokinetics of Ibuprofen under the condition of acute motor complete SCI will be
investigated. Secondary endpoints will permit preliminary statements about effects on
neuropathic pain, spasticity, and neurological function.
Reports of Suspected Motrin (Ibuprofen) Side Effects
Drug Ineffective (27),
Drug Hypersensitivity (18),
Toxic Epidermal Necrolysis (16),
Blood Glucose Increased (15),
Pain (13), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 15 ratings/reviews, Motrin has an overall score of 7.80. The effectiveness score is 8 and the side effect score is 8.53. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Motrin review by 21 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || menstrual cramps|
|Dosage & duration:|| || 2 tablets a day- morning and night taken twice a day. in the morning and night for the period of 34 days every month|
|Other conditions:|| || Ihave sinus but the pill does not have any side effects so it is advisable to take it to control men|
|Other drugs taken:|| || nothing else|
|Benefits:|| || I was relieved of menstrual cramps within 15 minutes of taking the pill and during nighttime i was able to sleep peacefully without any pain.I was able to carry out my routine work|
|Side effects:|| || There are absolutely no side effects|
|Comments:|| || it is advisable to take the tablet after breakfast and after dinner so that makes it twice a day but only for 4 days|
Motrin review by 58 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Considerably Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || arthritis pain, neck injury|
|Dosage & duration:|| || 800mg taken three times a day for the period of daily|
|Other conditions:|| || hypertension|
|Other drugs taken:|| || baclofen|
|Benefits:|| || decreased pain and inflamation, need no other pain medication for arthritis pain, have bee taking motrin for eight years with good results and little side effects other than mild nausea when taken without food.|
|Side effects:|| || motrin has caused mild nausea when taken without food and or milk. when taken after meals it did not cause any nausea, i have not noticed any other side effect.|
|Comments:|| || take motrin 800mg, 1 three times a day as needed for arthritis pain|
Motrin review by 38 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Considerably Effective|
|Side effects:|| || Extremely Severe Side Effects|
|Condition / reason:|| || flu|
|Dosage & duration:|| || max daily dose on packet (dosage frequency: each day) for the period of 3 days|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || significant reduction of pain due to the flu virus. this is a typical prescription for the flu, pain killers with lots of fluids. I was drawn to this tablets because they look appealing, the red capsules are easy to take and the caplets are coated in sugar. Normally I'd take paracetamol, which are dry and hard to swallow, I choose these to be kind to myself !!! I had no idea they could cause this reaction. they were good pain killers. |
|Side effects:|| || asthmatic condition. Heavy chest, dry cough, weakness, cumulative effect over days. Still prone to shortness of breath and tightness and heavy chest feelings, very sensitive to sulphides in wine and vinegars etc, was not before this. I only became aware of this connection when I took some I had left for a period pain, once again within seconds I was really ill.|
|Comments:|| || Not sure what this section requires ? It's a straight forward case of pain relief in response to the flu virus. the symptoms and the side effects became inter-twined, so it was not apparent that this drug was causing a reaction and worse than that I continued taking it as I became more and more ill. This is an over the counter drug, I would have appreciated more information from my pharmacist. I have tried to tell as many people as possible about what happened. After I have stopped taking the treatment I am left with a susceptibility to asthmatic type symptoms, it was also scary as I instinctively knew I was getting worse and became concerned something very serious was going on. I have never experience that type of "illness" before, normally I take time out and get well... this was an eye-opener.|
Page last updated: 2015-08-10