MOTRIN SUMMARY
The active ingredient in MOTRIN is ibuprofen, which is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. It is a white to off-white crystalline powder, with a melting point of 74° to 77°C. It is practically insoluble in water (<0.1 mg/mL), but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid.
In Children MOTRIN is indicated:
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For reduction of fever in patients aged 6 months and older.
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For relief of mild to moderate pain in patients aged 6 months and older.
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For relief of signs and symptoms of juvenile arthritis.
In Adults MOTRIN is indicated:
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For relief of mild to moderate pain.
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For treatment of primary dysmenorrhea.
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For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.
Since there have been no controlled trials to demonstrate whether there is any beneficial effect or harmful interaction with the use of ibuprofen in conjuction with aspirin, the combination cannot be recommended (see PRECAUTIONS -- Drug Interactions).
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