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Motrin (Ibuprofen) - Summary

 
 



Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS).
  • MOTRIN Suspension is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

  • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).
 

MOTRIN SUMMARY

MOTRIN® (ibuprofen) Suspension 100 mg/5 mL

The active ingredient in MOTRIN is ibuprofen, which is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. It is a white to off-white crystalline powder, with a melting point of 74° to 77°C. It is practically insoluble in water (<0.1 mg/mL), but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid.

In Children   MOTRIN is indicated:

  • For reduction of fever in patients aged 6 months and older.
  • For relief of mild to moderate pain in patients aged 6 months and older.
  • For relief of signs and symptoms of juvenile arthritis.

In Adults   MOTRIN is indicated:

  • For relief of mild to moderate pain.
  • For treatment of primary dysmenorrhea.
  • For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.

Since there have been no controlled trials to demonstrate whether there is any beneficial effect or harmful interaction with the use of ibuprofen in conjuction with aspirin, the combination cannot be recommended (see PRECAUTIONS -- Drug Interactions).


See all Motrin indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Motrin (Ibuprofen)

Intramuscular ketorolac versus oral ibuprofen for pain relief in first-trimester surgical abortion: a randomized clinical trial. [2014]
ketorolac for pain management during first-trimester surgical abortion... CONCLUSIONS: Intramuscular ketorolac does not offer superior pain control

Randomized clinical trial evaluating transdermal Ibuprofen for moderate to severe knee osteoarthritis. [2013]
pain management practices... CONCLUSIONS: The use of transdermal VALE-ibuprofen has beneficial clinical

Diclofenac with or without an antiemetic for acute migraine headaches in adults. [2013]
CONCLUSIONS: Oral diclofenac potassium 50 mg is an effective treatment

Randomized comparison between the combination of acetaminophen and ibuprofen and each constituent alone for analgesia following tonsillectomy in children. [2013]
individual constituents for analgesia following tonsillectomy in children... CONCLUSION: The combination of ibuprofen and acetaminophen was not superior to

Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. [2013]
CONCLUSIONS: Ibuprofen plus paracetamol combinations provided better

more studies >>

Clinical Trials Related to Motrin (Ibuprofen)

Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants [Completed]
it is a prospective randomized simple-blinded pilot trial with the principal aim to compare efficacy and tolerance between oral ibuprofen and intravenous ibuprofen in early curative closure of PDA in very low birth weight infants. The likelihood of ductal closure with only one or two doses of treatment is a secondary objective.

Early Versus Late Use of Ibuprofen for PDA Closure [Recruiting]
The primary objective is to evaluate the PDA closure rate of early vs. late use of Ibuprofen (Ibu). The investigators believe that early use of Ibu will have a higher PDA closure rate than later use of Ibu. Early use is defined as medication given before the infant reaches 96 hrs old. Late use is defined as medication given when infant is more than 96 hrs old.

The secondary objective is to measure the stress hormone and metabolic response (plasma catecholamines, glucose, and lactate) of neonates undergoing Ibu treatment of the PDA. The investigators believe that early ibuprofen will blunt the stress response greater than later use.

Study Evaluating A Novel Ibuprofen Formulation In Episodic Tension-Type Headache [Recruiting]
This study will compare the ability of a single-dose of a novel ibuprofen formulation to relieve pain compared to placebo and standard ibuprofen in the treatment of episodic tension-type headache.

To Compare the Pharmacokinetics Profiles of ISO 20, IBU 200 and IBU Plus ISO Combinations 200 + 20 [Recruiting]
This study will evaluate the pharmacokinetics plasma profile of 3 treatments: ISO 20, IBU 200 and IBU and ISO combinations (200 +20) given in single dose. This study is being conducted to support the submission for new indication in treatment of the combinations of Isosorbide Dinitrate and Ibuprofen as a treatment for Duchenne muscular dystrophy.

Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants [Recruiting]
We hypothesize that feeding preterm infants while they receive indomethacin or ibuprofen therapy for treatment of a patent ductus arteriosus will decrease the incidence of feeding intolerance and shorten the time period that infants need to tolerate full enteral nutrition. We also hypothesize that this intervention will minimize the alterations in intestinal permeability that occur with these drugs and will improve the infants' hemodynamic response to enteral nutrition

more trials >>

Reports of Suspected Motrin (Ibuprofen) Side Effects

Drug Ineffective (27)Vomiting (20)Nausea (20)Drug Hypersensitivity (18)Anxiety (18)Fatigue (16)Toxic Epidermal Necrolysis (16)Blood Glucose Increased (15)Abasia (13)Pain (13)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 15 ratings/reviews, Motrin has an overall score of 7.80. The effectiveness score is 8 and the side effect score is 8.53. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Motrin review by 21 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   menstrual cramps
Dosage & duration:   2 tablets a day- morning and night taken twice a day. in the morning and night for the period of 34 days every month
Other conditions:   Ihave sinus but the pill does not have any side effects so it is advisable to take it to control men
Other drugs taken:   nothing else
  
Reported Results
Benefits:   I was relieved of menstrual cramps within 15 minutes of taking the pill and during nighttime i was able to sleep peacefully without any pain.I was able to carry out my routine work
Side effects:   There are absolutely no side effects
Comments:   it is advisable to take the tablet after breakfast and after dinner so that makes it twice a day but only for 4 days

 

Motrin review by 58 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   arthritis pain, neck injury
Dosage & duration:   800mg taken three times a day for the period of daily
Other conditions:   hypertension
Other drugs taken:   baclofen
  
Reported Results
Benefits:   decreased pain and inflamation, need no other pain medication for arthritis pain, have bee taking motrin for eight years with good results and little side effects other than mild nausea when taken without food.
Side effects:   motrin has caused mild nausea when taken without food and or milk. when taken after meals it did not cause any nausea, i have not noticed any other side effect.
Comments:   take motrin 800mg, 1 three times a day as needed for arthritis pain

 

Motrin review by 38 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   flu
Dosage & duration:   max daily dose on packet (dosage frequency: each day) for the period of 3 days
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   significant reduction of pain due to the flu virus. this is a typical prescription for the flu, pain killers with lots of fluids. I was drawn to this tablets because they look appealing, the red capsules are easy to take and the caplets are coated in sugar. Normally I'd take paracetamol, which are dry and hard to swallow, I choose these to be kind to myself !!! I had no idea they could cause this reaction. they were good pain killers.
Side effects:   asthmatic condition. Heavy chest, dry cough, weakness, cumulative effect over days. Still prone to shortness of breath and tightness and heavy chest feelings, very sensitive to sulphides in wine and vinegars etc, was not before this. I only became aware of this connection when I took some I had left for a period pain, once again within seconds I was really ill.
Comments:   Not sure what this section requires ? It's a straight forward case of pain relief in response to the flu virus. the symptoms and the side effects became inter-twined, so it was not apparent that this drug was causing a reaction and worse than that I continued taking it as I became more and more ill. This is an over the counter drug, I would have appreciated more information from my pharmacist. I have tried to tell as many people as possible about what happened. After I have stopped taking the treatment I am left with a susceptibility to asthmatic type symptoms, it was also scary as I instinctively knew I was getting worse and became concerned something very serious was going on. I have never experience that type of "illness" before, normally I take time out and get well... this was an eye-opener.

See all Motrin reviews / ratings >>

Page last updated: 2014-12-01

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