MOTRIN SUMMARY
The active ingredient in MOTRIN is ibuprofen, which is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. It is a white to off-white crystalline powder, with a melting point of 74° to 77°C. It is practically insoluble in water (<0.1 mg/mL), but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid.
In Children MOTRIN is indicated:
-
For reduction of fever in patients aged 6 months and older.
-
For relief of mild to moderate pain in patients aged 6 months and older.
-
For relief of signs and symptoms of juvenile arthritis.
In Adults MOTRIN is indicated:
-
For relief of mild to moderate pain.
-
For treatment of primary dysmenorrhea.
-
For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.
Since there have been no controlled trials to demonstrate whether there is any beneficial effect or harmful interaction with the use of ibuprofen in conjuction with aspirin, the combination cannot be recommended (see PRECAUTIONS -- Drug Interactions).
|
MOTRIN NEWS HIGHLIGHTS Media Articles Related to Motrin (Ibuprofen)
Caldolor Is First Approved Injected Ibuprofen
Source: MedicineNet Aches, Pain, Fever Specialty [2009.06.15]
Title: Caldolor Is First Approved Injected Ibuprofen
Category: Health News
Created: 6/13/2009 7:00:00 AM
Last Editorial Review: 6/15/2009
FDA Okays Injectable Ibuprofen
Source: MedPage Today Product Alert [2009.06.12]
LITTLE FALLS, N.J. (MedPage Today) -- The FDA has approved an intravenous form of ibuprofen -- to be marketed under the name Caldolor -- for the relief of pain and fever.
Ibuprofen May Cut Alzheimer's Risk
Source: MedicineNet Cox-2 Inhibitors Specialty [2008.05.06]
Title: Ibuprofen May Cut Alzheimer's Risk
Category: Health News
Created: 5/6/2008
Last Editorial Review: 5/6/2008
Painkillers May Be Good for the Prostate (HealthDay)
Source: Y! Health Prostate Cancer News [2009.06.20]
HealthDay - SATURDAY, June 20 (HealthDay News) -- Taking over-the-counter
painkillers such as aspirin and ibuprofen might help men avoid prostate
problems.
Published Studies Related to Motrin (Ibuprofen)
ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial. [2009]
BACKGROUND: Primary dysmenorrhea is estimated to affect 40-50% of menstruating young women... CONCLUSIONS: In patients experiencing acute visceral pain as a result of primary dysmenorrhea, dexibuprofen [generic for Motrin] was associated with a dose-dependent effective analgesia; this effect was at least equivalent to that of the double dose of ibuprofen. With its lower body-loading dose, dexibuprofen expands the alternatives available to treat this condition.
A Randomized, Double-Blind, Placebo-Controlled Trial on Intravenous Ibuprofen L-Lysine for the Early Closure of Nonsymptomatic Patent Ductus Arteriosus within 72 Hours of Birth in Extremely Low-Birth-Weight Infants. [2008.12.09]
A multicenter, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy and safety of intravenous (IV) ibuprofen [generic for Motrin] (L-lysine) for the early closure of nonsymptomatic patent ductus arteriosus (PDA) within 72 hours of birth in extremely low-birth-weight (ELBW) infants with evidence of ductal shunting by echocardiogram...
Formulation of a extended release tablet containing dexibuprofen. [2008.12]
Dexibuprofen [generic for Motrin], or S(+)-ibuprofen, is the pharmacologically effective enantiomer of racemic ibuprofen. Since dexibuprofen has a low melting point, the amorphous form having a high melting point was prepared with the fused solid dispersion method.The Cmax was reached due to the rapid absorption of the immediate release portion of the dual release tablet and the AUC was maintained due to continuous absorption of the extended release portion.
Randomized pilot study comparing oral ibuprofen with intravenous ibuprofen in very low birth weight infants with patent ductus arteriosus. [2008.12]
CONCLUSIONS: In very low birth weight infants, the rate of early ductal closure with oral ibuprofen [generic for Motrin] is at least as good as with the intravenous route. Ductal closure may be obtained with an incomplete course of ibuprofen. Oral ibuprofen is associated with fewer adverse effects. However, a larger sample is needed for more definitive conclusions.
The effects and safety of dexibuprofen compared with ibuprofen in febrile children caused by upper respiratory tract infection. [2008.12]
AIM: To evaluate the antipyretic efficacy and tolerability of dexibuprofen [generic for Motrin] compared with ibuprofen in children with fever caused by upper respiratory tract infection (URTI)... CONCLUSIONS: Dexibuprofen is as effective and tolerable as ibuprofen. A dose of 5 mg kg(-1) and 7 mg kg(-1) dexibuprofen in place of 10 mg kg(-1) ibuprofen would be sufficient to control fever caused by URTI in children.
Clinical Trials Related to Motrin (Ibuprofen)
Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants [Completed]
it is a prospective randomized simple-blinded pilot trial with the principal aim to compare
efficacy and tolerance between oral ibuprofen and intravenous ibuprofen in early curative
closure of PDA in very low birth weight infants. The likelihood of ductal closure with only
one or two doses of treatment is a secondary objective.
Ibuprofen-PC Compared With Ibuprofen in a GI Safety Trial [Active, not recruiting]
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-Associated Ulcers [Active, not recruiting]
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of
development of ibuprofen-associated ulcers in patients who require long-term daily use of
ibuprofen.
Celecoxib, Ibuprofen and the Antiplatelet Effect of Aspirin [Completed]
Study design: Single center, placebo-controlled, double blind, parallel groups. To evaluate
the potential interaction between aspirin and ibuprofen or celecoxib in patients with
osteoarthritis (OA) and documented stable ischemic heart disease, a total of 24 patients
chronically treated with aspirin will be randomly assigned to one of the 3 treatment groups:
1) celecoxib 200 mg bid; 2) ibuprofen 600 mg tid; 3) placebo.
Treatment of Fever Due to Malaria With Ibuprofen [Completed]
Drugs to treat fever are widely used in children with fever. But there is a controversy about
the benefit of reducing fever in children with malaria. Ibuprofen is often used to treat
malarial fever. This study evaluates the capacity of ibuprofen to reduce fever in malaria.
The effect of ibuprofen on fever compared to only mechanical measures is investigated in
children with malaria.
|
MOTRIN PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 10 ratings/reviews, Motrin has an overall score of 8. The effectiveness score is 8.40 and the side effect score is 8.40. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Motrin review by 32 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | back stiffness |
| Dosage & duration: | | 800mg taken 3 times /month for the period of 12 onths |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | loss of stiffness and more mobility. After a heavy weight workout, taking Miotrin relieved the stiffness and iflamation around lower back. Next day mobility and flesibility was much greater, and less pain. |
| Side effects: | | none. |
| Comments: | | either before or after a workout, usually take about 800 mg of Motrin with lots of water or a glass of milk. Also, use a heating pads against lower back. It works great with motrin. |
|
| | Motrin review by 16 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Sprained Ankle |
| Dosage & duration: | | 200 mg tablets taken three times a day for the period of 2 weeks |
| Other conditions: | | Nothing |
| Other drugs taken: | | Nothing | | |
Reported Results |
| Benefits: | | The Ibuprofen helped relieve pain and swelling from the sprained ankle. It lowered the amount of time it took to heal the ankle and also provided lasting relief from discomfort caused by swelling and pain. Swelling was substantially lowered after a week period and steps were taken to allow the ankle to regain flexibility due to subsiding of pain. |
| Side effects: | | There were no treatment side effects except for occasional nausea or drowsiness. Drowsiness however helped the patient sleep faster and thus avoid discomfort of laying in bed with a sprained ankle. Overall it simply lowered the amount of time it took to heal the ankle and also provided lasting relief from discomfort caused by swelling and pain. |
| Comments: | | Three two-hundred milligram tablets of Ibuprofen were taken for two weeks daily. The sprained-ankle caused substantial pain, discomfort and swelling. In order to begin the healing process and rehabilitation of the ankle's flexibility, Ibuprofen was taken. Ibuprofen allowed the lessening of swelling and also resulted in a subsiding of pain and thus a faster healing process. Side-effects were low and insignificant though there might be effects if taken in the long term. |
|
| | Motrin review by 38 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | flu |
| Dosage & duration: | | max daily dose on packet (dosage frequency: each day) for the period of 3 days |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | significant reduction of pain due to the flu virus. this is a typical prescription for the flu, pain killers with lots of fluids. I was drawn to this tablets because they look appealing, the red capsules are easy to take and the caplets are coated in sugar. Normally I'd take paracetamol, which are dry and hard to swallow, I choose these to be kind to myself !!! I had no idea they could cause this reaction. they were good pain killers. |
| Side effects: | | asthmatic condition. Heavy chest, dry cough, weakness, cumulative effect over days. Still prone to shortness of breath and tightness and heavy chest feelings, very sensitive to sulphides in wine and vinegars etc, was not before this. I only became aware of this connection when I took some I had left for a period pain, once again within seconds I was really ill. |
| Comments: | | Not sure what this section requires ? It's a straight forward case of pain relief in response to the flu virus. the symptoms and the side effects became inter-twined, so it was not apparent that this drug was causing a reaction and worse than that I continued taking it as I became more and more ill. This is an over the counter drug, I would have appreciated more information from my pharmacist. I have tried to tell as many people as possible about what happened. After I have stopped taking the treatment I am left with a susceptibility to asthmatic type symptoms, it was also scary as I instinctively knew I was getting worse and became concerned something very serious was going on. I have never experience that type of "illness" before, normally I take time out and get well... this was an eye-opener. |
|
|
|
Page last updated: 2009-06-20
|
