The adverse reactions caused by morphine are essentially those observed with other opioid analgesics. They include the following major hazards: respiratory depression, apnea, and to a lesser degree, circulatory depression, respiratory arrest, shock and cardiac arrest.
Most Frequently Observed
Constipation, lightheadedness, dizziness, sedation, nausea, vomiting, sweating, dysphoria and euphoria.
Some of these effects seem to be more prominent in ambulatory patients and in those not experiencing severe pain. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down.
Less Frequently Observed Reactions
Central Nervous System
Weakness, headache, agitation, tremor, uncoordinated muscle movements, seizure, alterations of mood (nervousness, apprehension, depression, floating feelings), dreams, muscle rigidity, transient hallucinations and disorientation, visual disturbances, insomnia and increased intracranial pressure
Dry mouth, biliary tract spasm, laryngospasm, anorexia, diarrhea, cramps, taste alterations, constipation, ileus, intestinal obstruction, and increases in hepatic enzymes
Flushing of the face, chills, tachycardia, bradycardia, palpitation, faintness, syncope, hypotension and hypertension
Urine retention or hesitance, reduced libido and/or potency
Pruritus, urticaria, other skin rashes, edema and diaphoresis
Antidiuretic effect, paresthesia, muscle tremor, blurred vision, nystagmus, diplopia, miosis and anaphylaxis
REPORTS OF SUSPECTED MORPHINE SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Morphine. The information is not vetted and should not be considered as verified clinical evidence.
Possible Morphine side effects / adverse reactions in 59 year old male
Reported by a consumer/non-health professional from United States on 2011-10-03
Patient: 59 year old male
Reactions: Drug Ineffective, Tension
Other drugs received by patient: Ultram; Lasix; Meloxicam; Neurontin; Coreg; Coumadin; Lisinopril; Levothyroxine
Possible Morphine side effects / adverse reactions in 66 year old male
Reported by a pharmacist from United States on 2011-10-03
Patient: 66 year old male weighing 58.5 kg (128.7 pounds)
Reactions: Mental Status Changes
Adverse event resulted in: hospitalization
Possible Morphine side effects / adverse reactions in 31 year old female
Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2011-10-05
Patient: 31 year old female
Reactions: Back Pain, Pain in Extremity, Staphylococcal Infection
Dosage: 2 mg
Indication: Procedural Pain
Dosage: 4 mg