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Morphine (Morphine Sulfate) - Side Effects and Adverse Reactions



The adverse reactions caused by morphine are essentially those observed with other opioid analgesics. They include the following major hazards: respiratory depression, apnea, and to a lesser degree, circulatory depression, respiratory arrest, shock and cardiac arrest.

Most Frequently Observed

Constipation, lightheadedness, dizziness, sedation, nausea, vomiting, sweating, dysphoria and euphoria.

Some of these effects seem to be more prominent in ambulatory patients and in those not experiencing severe pain. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down.

Less Frequently Observed Reactions

Central Nervous System

Weakness, headache, agitation, tremor, uncoordinated muscle movements, seizure, alterations of mood (nervousness, apprehension, depression, floating feelings), dreams, muscle rigidity, transient hallucinations and disorientation, visual disturbances, insomnia and increased intracranial pressure


Dry mouth, biliary tract spasm, laryngospasm, anorexia, diarrhea, cramps, taste alterations, constipation, ileus, intestinal obstruction, and increases in hepatic enzymes


Flushing of the face, chills, tachycardia, bradycardia, palpitation, faintness, syncope, hypotension and hypertension


Urine retention or hesitance, reduced libido and/or potency


Pruritus, urticaria, other skin rashes, edema and diaphoresis


Antidiuretic effect, paresthesia, muscle tremor, blurred vision, nystagmus, diplopia, miosis and anaphylaxis


Below is a sample of reports where side effects / adverse reactions may be related to Morphine. The information is not vetted and should not be considered as verified clinical evidence.

Possible Morphine side effects / adverse reactions in 59 year old male

Reported by a consumer/non-health professional from United States on 2011-10-03

Patient: 59 year old male

Reactions: Drug Ineffective, Tension

Suspect drug(s):

Other drugs received by patient: Ultram; Lasix; Meloxicam; Neurontin; Coreg; Coumadin; Lisinopril; Levothyroxine

Possible Morphine side effects / adverse reactions in 66 year old male

Reported by a pharmacist from United States on 2011-10-03

Patient: 66 year old male weighing 58.5 kg (128.7 pounds)

Reactions: Mental Status Changes

Adverse event resulted in: hospitalization

Suspect drug(s):

Possible Morphine side effects / adverse reactions in 31 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2011-10-05

Patient: 31 year old female

Reactions: Back Pain, Pain in Extremity, Staphylococcal Infection

Suspect drug(s):
    Dosage: 2 mg
    Indication: Procedural Pain

    Dosage: 4 mg

See index of all Morphine side effect reports >>

Drug label data at the top of this Page last updated: 2006-04-07

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