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Morphine (Morphine Sulfate) - Summary

 
 



MORPHINE SUMMARY

Each extended-release tablet, for oral administration contains 100 mg of morphine sulfate USP. Morphine sulfate is an opioid analgesic.

Morphine sulfate extended-release tablets are a controlled release oral morphine formulation indicated for the relief of moderate to severe pain. They are intended for use in patients who require repeated dosing with potent opioid analgesics over periods of more than a few days.


See all Morphine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Morphine

A decade-long effort in genetic engineering is close to re-programming yeast cells to make palliative medicines in stainless steel vats
Source: Genetics News From Medical News Today [2014.08.26]
For centuries poppy plants have been grown to provide opium, the compound from which morphine and other important medicines such as oxycodone are derived.

Tackling inflammatory pain
Source: Immune System / Vaccines News From Medical News Today [2014.08.29]
Pain from inflammation sidelines thousands of Americans each year. Many face a tough choice: deal with the pain, take a potentially addictive opioid or use a nonsteroidal anti-inflammatory drug that...

'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds
Source: MedicineNet Chronic Pain Specialty [2014.08.29]
Title: 'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds
Category: Health News
Created: 8/29/2014 9:35:00 AM
Last Editorial Review: 8/29/2014 12:00:00 AM

Iroko Pharmaceuticals gains FDA approval of ZORVOLEX® for management of osteoarthritis pain
Source: Arthritis / Rheumatology News From Medical News Today [2014.08.28]
Iroko Pharmaceuticals, LLC, a global specialty pharmaceutical company dedicated to advancing the science of analgesia, has announced the United States Food and Drug Administration (FDA) has...

States that legalize medical marijuana 'have fewer deaths from opioid painkillers'
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2014.08.26]
Annual deaths from prescription painkillers are, on average, 25% lower in states that legalize medical marijuana, according to a new study from Johns Hopkins researchers.

more news >>

Published Studies Related to Morphine

Periarticular infiltration of 0.25% bupivacaine on top of femoral nerve block and intrathecal morphine improves quality of pain control after total knee arthroplasty: a randomized double-blind placebo controlled clinical trial. [2012]
CONCLUSION: Adding periarticular infiltration to femoral block and intrathecal

Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back pain. [2012]
Although often successful in acute settings, long-term use of opioid pain medications may be accompanied by waning levels of analgesic response not readily attributable to advancing underlying disease, necessitating dose escalation to attain pain relief... Improvements in pain and functional ability were observed.

Tolerability and efficacy of two synergistic ratios of oral morphine and oxycodone combinations versus morphine in patients with chronic noncancer pain. [2012]
SETTING: Clinical study centers in Australia... CONCLUSION: A 3:2 or 1:2 fixed ratio combination of morphine and oxycodone (MOX)

Long-acting morphine following hip or knee replacement: a randomized, double-blind and placebo-controlled trial. [2012]
routine postoperative regimen for total hip or knee replacement surgery... CONCLUSIONS: Thirty milligrams twice per day of long-acting morphine from days 1

The effect of intravenous morphine on the level of spinal anesthesia with lidocaine. [2012]
CONCLUSION: Although some studies had proved the efficacy of systemic use of

more studies >>

Clinical Trials Related to Morphine

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

INFUSE Morphine Study [Completed]
Double-blind study comparing the pharmacokinetics, safety and tolerability of morphine administered subcutaneously (SC) with and without human recombinant hyaluronidase (HYLENEX) and intravenously conducted in patients in a hospice care setting or through a palliative care medicine setting. In this within-patient controlled study, each eligible study patient receives a single injection by each of the three methods of morphine administration, sequentially on three consecutive days, according to the order specified by a randomization schedule.

Each of the three injections consists of 5 mg of morphine (1. 0 mL of 5 mg/mL solution). The HYLENEX injection will be 1 mL of 150 units. Although the IV administration will not be blinded, the two SC injections will be double-blinded, using the same volume of normal saline (0. 9% sodium chloride) placebo (1. 0 mL) as HYLENEX.

Problems With Morphine Use in Patients With a Severe Brain Injury [Active, not recruiting]
Hypothesis: During severe brain trauma (injury, surgery) the ensuing inflammatory response in the central nervous system (CNS) results in a decrease in the expression of the transporter protein p-glycoprotein (PGP) in the blood brain barrier. This loss results in the penetration into the brain of certain drugs that are normally excluded by the transporter protein. In this study the working hypothesis is that the agitation observed in patients with CNS trauma treated with morphine is related to the inflammation evoked loss of PGP in the blood brain barrier and the accumulation of the morphine metabolite 3-morphine glucuronide.

more trials >>

Reports of Suspected Morphine Side Effects

Completed Suicide (135)Toxicity TO Various Agents (118)Death (83)Cardio-Respiratory Arrest (83)Cardiac Arrest (78)Respiratory Arrest (77)Drug Abuse (68)Drug Ineffective (41)Vomiting (41)Somnolence (38)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 2 ratings/reviews, Morphine has an overall score of 5.50. The effectiveness score is 7 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
 

Morphine review by 47 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   post surgery extreme pain
Dosage & duration:   15 mg IR Tablets taken 2 x per day for the period of long term
Other conditions:   umbilical hernia
Other drugs taken:   too many to list
  
Reported Results
Benefits:   Relief of chronic intermittent pain. Also, relief from chronic ( post ) repeated surgery and repeated hospitalizations.
Side effects:   No side effects even after prolonged use for intermittent chronic pain. Have been taking 15 mg tablets on and off ( not taken every day ) for over 2 years.
Comments:   Currently being used on a as needed basis for chronic pain. Also, used for sudden onset of severe pain from post surgical complications.

 

Morphine review by 64 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   for tramflap surgery,implant removal
Dosage & duration:   not sure, administered by doctor (dosage frequency: only during surgery) for the period of not sure
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   none
Side effects:   I went into shock during recovery from surgery and was told I had allergic reaction to the morphine and not to ever take it again. I saw red spiders and hallucinated for weeks afterwards.
Comments:   Not sure of any details, since it was during surgery and I was not awake.

See all Morphine reviews / ratings >>

Page last updated: 2014-08-29

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