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Morphine (Morphine Sulfate) - Summary

 
 



MORPHINE SUMMARY

Each extended-release tablet, for oral administration contains 100 mg of morphine sulfate USP. Morphine sulfate is an opioid analgesic.

Morphine sulfate extended-release tablets are a controlled release oral morphine formulation indicated for the relief of moderate to severe pain. They are intended for use in patients who require repeated dosing with potent opioid analgesics over periods of more than a few days.


See all Morphine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Morphine

Data presented at NANS 2014 demonstrate long-term, low back pain relief with Spectra Spinal Cord Stimulator System
Source: Medical Devices / Diagnostics News From Medical News Today [2014.12.20]
New retrospective data evaluating the Boston Scientific Corporation (NYSE: BSX) Precision Spectra™ Spinal Cord Stimulator (SCS) System demonstrate that the device provided sustained, highly...

Novel agent decreases neuropathic pain in patients with type 2 diabetes
Source: Diabetes News From Medical News Today [2014.12.19]
Molecular Medicine, a peer-reviewed biomedical journal published by the Feinstein Institute Press, published the results of a new study reporting clinically significant pain reduction in type 2...

The difficulties of treating shoulder pain in baseball pitchers
Source: Bones / Orthopedics News From Medical News Today [2014.12.15]
Results of treating shoulder pain in baseball pitchers and other throwing athletes are not as predictable as doctors, patients and coaches would like to think, according to a report in the journal...

Commonly prescribed painkiller not effective in controlling lower back pain
Source: Seniors / Aging News From Medical News Today [2014.12.15]
A new study in the journal Neurology shows that pregabalin is not effective in controlling the pain associated with lumbar spinal stenosis, the most common type of chronic lower back pain in older...

Painful Hands, Hurting Hearts?
Source: MedPage Today Rheumatology [2014.12.15]
(MedPage Today) -- Symptomatic hand osteoarthritis was linked with coronary heart disease.

more news >>

Published Studies Related to Morphine

Evaluation of a single-dose, extended-release epidural morphine formulation for pain control after lumbar spine surgery. [2014]
DepoDur, an extended-release epidural morphine, has been used effectively for postoperative pain control following many orthopaedic and general surgery procedures and has provided prolonged analgesia when compared with Duramorph. The goal of this article was to compare the safety and analgesic efficacy of DepoDur versus Duramorph after lumbar spine surgery...

Morphine decreases clopidogrel concentrations and effects: a randomized, double-blind, placebo-controlled trial. [2014]
effects on platelets... CONCLUSIONS: Morphine delays clopidogrel absorption, decreases plasma levels of

The postoperative analgesic effect of morphine and paracetamol in the patients undergoing laparotomy, using PCA method. [2013]
CONCLUSION: Morphine seems to be more effective at 2 and 4 hours, but after 4

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

Effect of morphine on lower urinary tract discomfort after transurethral resection of prostate under general anesthesia: a randomised clinical study. [2013]
TURP-related LUT discomfort symptoms... CONCLUSION: Based on these results, we conclude that morphine effectively reduces

more studies >>

Clinical Trials Related to Morphine

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

INFUSE Morphine Study [Completed]
Double-blind study comparing the pharmacokinetics, safety and tolerability of morphine administered subcutaneously (SC) with and without human recombinant hyaluronidase (HYLENEX) and intravenously conducted in patients in a hospice care setting or through a palliative care medicine setting. In this within-patient controlled study, each eligible study patient receives a single injection by each of the three methods of morphine administration, sequentially on three consecutive days, according to the order specified by a randomization schedule.

Each of the three injections consists of 5 mg of morphine (1. 0 mL of 5 mg/mL solution). The HYLENEX injection will be 1 mL of 150 units. Although the IV administration will not be blinded, the two SC injections will be double-blinded, using the same volume of normal saline (0. 9% sodium chloride) placebo (1. 0 mL) as HYLENEX.

Problems With Morphine Use in Patients With a Severe Brain Injury [Active, not recruiting]
Hypothesis: During severe brain trauma (injury, surgery) the ensuing inflammatory response in the central nervous system (CNS) results in a decrease in the expression of the transporter protein p-glycoprotein (PGP) in the blood brain barrier. This loss results in the penetration into the brain of certain drugs that are normally excluded by the transporter protein. In this study the working hypothesis is that the agitation observed in patients with CNS trauma treated with morphine is related to the inflammation evoked loss of PGP in the blood brain barrier and the accumulation of the morphine metabolite 3-morphine glucuronide.

more trials >>

Reports of Suspected Morphine Side Effects

Completed Suicide (135)Toxicity TO Various Agents (118)Death (83)Cardio-Respiratory Arrest (83)Cardiac Arrest (78)Respiratory Arrest (77)Drug Abuse (68)Drug Ineffective (41)Vomiting (41)Somnolence (38)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 2 ratings/reviews, Morphine has an overall score of 5.50. The effectiveness score is 7 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
 

Morphine review by 47 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   post surgery extreme pain
Dosage & duration:   15 mg IR Tablets taken 2 x per day for the period of long term
Other conditions:   umbilical hernia
Other drugs taken:   too many to list
  
Reported Results
Benefits:   Relief of chronic intermittent pain. Also, relief from chronic ( post ) repeated surgery and repeated hospitalizations.
Side effects:   No side effects even after prolonged use for intermittent chronic pain. Have been taking 15 mg tablets on and off ( not taken every day ) for over 2 years.
Comments:   Currently being used on a as needed basis for chronic pain. Also, used for sudden onset of severe pain from post surgical complications.

 

Morphine review by 64 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   for tramflap surgery,implant removal
Dosage & duration:   not sure, administered by doctor (dosage frequency: only during surgery) for the period of not sure
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   none
Side effects:   I went into shock during recovery from surgery and was told I had allergic reaction to the morphine and not to ever take it again. I saw red spiders and hallucinated for weeks afterwards.
Comments:   Not sure of any details, since it was during surgery and I was not awake.

See all Morphine reviews / ratings >>

Page last updated: 2014-12-20

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