Media Articles Related to Monurol (Fosfomycin)
Boosting the body's natural ability to fight urinary tract infections
Source: MRSA / Drug Resistance News From Medical News Today [2015.05.04]
Experimental drug that stabilizes immune defense protein HIF-1alpha protects against major UTI pathogenAbundance of bacteria in the opening of a mouse bladder (center) is significantly reduced...
Urinary Tract Infections (UTIs)
Source: MedicineNet Bedwetting Specialty [2015.02.09]
Title: Urinary Tract Infections (UTIs)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/9/2015 12:00:00 AM
Urinary Tract Infections in Children
Source: MedicineNet Bedwetting Specialty [2015.02.05]
Title: Urinary Tract Infections in Children
Category: Diseases and Conditions
Created: 2/1/2010 12:00:00 AM
Last Editorial Review: 2/5/2015 12:00:00 AM
Urinary Tract Infection (UTI) Symptoms
Source: MedicineNet Urine Infection Specialty [2014.12.01]
Title: Urinary Tract Infection (UTI) Symptoms
Category: Doctor's Views
Created: 12/2/2008 12:00:00 AM
Last Editorial Review: 12/1/2014 12:00:00 AM
Urinary Tract Infection (UTI) Symptoms Pictures Slideshow
Source: MedicineNet Urine Infection Specialty [2014.08.19]
Title: Urinary Tract Infection (UTI) Symptoms Pictures Slideshow
Created: 12/4/2008 12:00:00 AM
Last Editorial Review: 8/19/2014 12:00:00 AM
Published Studies Related to Monurol (Fosfomycin)
A randomized comparative study of single-dose fosfomycin and 5-day ciprofloxacin in female patients with uncomplicated lower urinary tract infections. [2010.12]
Uncomplicated lower urinary tract infections (UTIs) are the most frequent infections in females... It was concluded that the use of FMT as a first-line treatment in the empirical treatment of uncomplicated UTIs might have a positive impact on the problem of resistance to other antibiotics.
Fosfomycin versus other antibiotics for the treatment of cystitis: a
meta-analysis of randomized controlled trials. 
other antibiotics for the treatment of patients with cystitis... CONCLUSIONS: In the era of high drug resistance rates, reported even among
Fosfomycin in a single dose versus a 7-day course of amoxicillin-clavulanate for the treatment of asymptomatic bacteriuria during pregnancy. [2009.12]
The purpose of this paper was to compare the efficacy of a single dose of 3 g of fosfomycin to that of a 7-day regimen of amoxicillin-clavulanate in the treatment of asymptomatic bacteriuria during pregnancy. A randomised, prospective, interventional, analytical, longitudinal study was undertaken, in which the efficacy of two antibiotic regimens (one short and the other long) in the treatment of pregnant women with asymptomatic bacteriuria is compared...
Intravenous and intramuscular pharmacokinetics of a single-daily dose of disodium-fosfomycin in cattle, administered for 3 days. [2007.02]
Pharmacokinetic parameters of fosfomycin in cattle were determined after administration of buffered disodium fosfomycin either intravenously (i.v.) or intramuscularly (i.m.) at a dose of 20 mg/kg/day for 3 days. Calculated concentrations at time zero and maximum serum concentrations were 34.42 and 10.18 mug/mL, respectively.
Prevention of recurrent lower urinary tract infections by long-term administration of fosfomycin trometamol. Double blind, randomized, parallel group, placebo controlled study. 
Three hundred and seventeen non pregnant females, suffering of recurrent lower urinary tract infections (UTIs; at least three episodes in the preceding 12 months) were enrolled in a double blind, randomized placebo (PL) controlled, parallel group clinical study, addressed to evaluate the efficacy and safety of fosfomycin trometamol (CAS 78964-85-9, FT, Monuril) in the prevention of infectious recurrences of lower urinary tract.
Clinical Trials Related to Monurol (Fosfomycin)
Immediate vs. Conditional Use of Antibiotics in Uncomplicated Urinary Tract Infection (UTI) - ICUTI [Recruiting]
In this study, patients with uncomplicated urinary infection are investigated. It is
investigated if treatment of only symptoms of the uncomplicated urinary infection is as
effective as treatment with antibiotics with respect to the outcome of the urinary
infection. If this is the case, the use of antibiotics in the treatment of uncomplicated
urinary infections might be reduced.
Secondary aim of the study is the safety evaluation of both treatment strategies with
respect to SAEs during treatment. Additionally, relapse frequency after 28 days is
Single Dose Monurol for Treatment of Acute Cystitis [Recruiting]
Urinary tract infecton (UTI) is a very common problem in young healthy women, afflicting
approximately one-half of women by their late 20's. One of the most common antibiotics used
to treat UTIs is Trimethoprim-sulfa (TMP-SMX), usually for total of three days. However,
concerns about increased antibiotic resistance have led to increased interest in studying
other antibiotics for UTI.
An alternative antibiotic which is also FDA approved for the treatment of UTIs is fosfomycin
(Monurol). The effectiveness of fosfomycin in curing UTIs when given as a single dose is not
well studied. The purpose of this research study is to determine what the cure rates are
with a single dose of fosfomycin versus the more standard 3-day course of TMP-SMX.
Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative and / or Gram-positive Bacterial Colonization [Recruiting]
To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin Fosfomycin
Inhalation System (AFIS) versus aerosolized placebo in mechanically ventilated patients with
Gram-negative and / or Gram-positive bacterial colonization.
Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women [Recruiting]
Developed before the establishment of a structured process for drug assessment,
nitrofurantoin is now being prescribed frequently given the rise in multi-resistant
gram-negative pathogens. Doubts remain regarding fosfomycin's long-term clinical
effectiveness. A randomized, controlled trial is needed to explore the clinical
effectiveness and better define the side effect profiles of both nitrofurantoin and
fosfomycin. This multi-center open trial will randomize 600 non-pregnant women at three
international sites (200 each in Poland, Switzerland, and Israel) at increased risk for
carriage of resistant uropathogens and with suspicion of uncomplicated lower urinary tract
infection to receive either oral nitrofurantoin 100 mg three times daily for 5 days or a
single 3g dose of oral fosfomycin. Patients will be followed for clinical and bacteriologic
response at days 14 and 28 post therapy completion. The study hypothesis holds that
nitrofurantoin will be superior to fosfomycin in clinical efficacy at final follow-up.
Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative Pneumonia [Recruiting]
To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin fosfomycin
inhalation system (AFIS) versus aerosolized placebo to treat Gram-negative pneumonia in
mechanically ventilated patients receiving IV antibiotics.