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Monopril-HCT (Fosinopril Sodium / Hydrochlorothiazide) - Summary

 
 



USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, MONOPRIL-HCT should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.

 

MONOPRIL-HCT SUMMARY

Fosinopril is converted to fosinoprilat by hepatic cleavage of the ester group. Fosinoprilat, the active metabolite of fosinopril, is a non-sulfhydryl angiotensin-converting enzyme inhibitor. Hydrochlorothiazide is a diuretic.

MONOPRIL-HCT (fosinopril sodium-hydrochlorothiazide tablets) is indicated for the treatment of hypertension.

These fixed dose combinations are not indicated for initial therapy. (See DOSAGE AND ADMINISTRATION.)

In using MONOPRIL-HCT, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that fosinopril does not have a similar risk (see WARNINGS: Neutropenia/Agranulocytosis).

ACE inhibitors (for which adequate data are available) cause a higher rate of angioedema in black than in non-black patients (see WARNINGS: Head and Neck Angioedema and Intestinal Angioedema).


See all Monopril-HCT indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Monopril-HCT (Fosinopril / Hydrochlorothiazide)

Hypertension before the age of 55 increases risk of cardiovascular death
Source: Cardiovascular / Cardiology News From Medical News Today [2017.05.19]
When someone gets diagnosed with hypertension, either early (before the age of 55) or later in life, can have important health ramifications.

Options Emerging for Pulmonary Hypertension, Chronic Cough
Source: Medscape Allergy & Clinical Immunology Headlines [2017.05.15]
Results from the MERIT study evaluating macitentan in pulmonary hypertension will be presented at the American Thoracic Society Conference, along with a study of a P2X3 antagonist for chronic cough.
Medscape Medical News

Simple blood tests lead to improved hypertension treatment in African countries
Source: Hypertension News From Medical News Today [2017.05.04]
Using two simple blood tests, Western University researchers were able to drastically improve treatment for resistant hypertension across three sites in Nigeria, Kenya and South Africa.

Diabetes and hypertension: What is the relationship?
Source: Hypertension News From Medical News Today [2017.04.29]
Hypertension, or high blood pressure, is linked to diabetes, and each condition can make the other worse. How can people reduce the associated risks?

Endocrine Society issues statement to improve detection of curable forms of hypertension
Source: Endocrinology News From Medical News Today [2017.04.10]
A new Scientific Statement issued by the Endocrine Society advises healthcare providers on ways to spot hormonal causes of high blood pressure that can be cured with surgery or treated effectively...

more news >>


Page last updated: 2017-05-19

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