USE IN PREGNANCY
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, MONOPRIL-HCT should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.
|
|
MONOPRIL-HCT SUMMARY
Fosinopril is converted to fosinoprilat by hepatic cleavage of the ester group. Fosinoprilat, the active metabolite of fosinopril, is a non-sulfhydryl angiotensin-converting enzyme inhibitor. Hydrochlorothiazide is a diuretic.
MONOPRIL-HCT (fosinopril sodium-hydrochlorothiazide tablets) is indicated for the treatment of hypertension.
These fixed dose combinations are not indicated for initial therapy. (See DOSAGE AND ADMINISTRATION.)
In using MONOPRIL-HCT, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that fosinopril does not have a similar risk (see WARNINGS: Neutropenia/Agranulocytosis).
ACE inhibitors (for which adequate data are available) cause a higher rate of angioedema in black than in non-black patients (see WARNINGS: Head and Neck Angioedema and Intestinal Angioedema).
|
|
NEWS HIGHLIGHTSMedia Articles Related to Monopril-HCT (Fosinopril / Hydrochlorothiazide)
High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes Source: MedicineNet Facial Nerve Problems Specialty [2017.09.19] Title: High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes Category: MedicineNet Quiz Created: 2/9/2011 12:00:00 AM Last Editorial Review: 9/19/2017 6:02:11 PM
Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy) Source: MedicineNet Congenital Heart Disease Specialty [2017.07.26] Title: Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy) Category: Diseases and Conditions Created: 12/31/1997 12:00:00 AM Last Editorial Review: 7/26/2017 12:00:00 AM
High Blood Pressure (Hypertension) Source: MedicineNet Polycystic Ovary Specialty [2017.03.31] Title: High Blood Pressure (Hypertension) Category: Symptoms and Signs Created: 1/15/2014 12:00:00 AM Last Editorial Review: 3/31/2017 12:00:00 AM
Portal Hypertension Source: MedicineNet nitroglycerin Specialty [2016.09.06] Title: Portal Hypertension Category: Diseases and Conditions Created: 1/31/2005 12:00:00 AM Last Editorial Review: 9/6/2016 12:00:00 AM
Picture of Hypertension Source: MedicineNet betaxolol ophthalmic Specialty [2014.12.09] Title: Picture of Hypertension Category: Images Created: 2/3/2011 12:00:00 AM Last Editorial Review: 12/9/2014 12:00:00 AM
|
|
Page last updated: 2017-09-19
|