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Monopril-HCT (Fosinopril Sodium / Hydrochlorothiazide) - Summary

 
 



USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, MONOPRIL-HCT should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.

 

MONOPRIL-HCT SUMMARY

Fosinopril is converted to fosinoprilat by hepatic cleavage of the ester group. Fosinoprilat, the active metabolite of fosinopril, is a non-sulfhydryl angiotensin-converting enzyme inhibitor. Hydrochlorothiazide is a diuretic.

MONOPRIL-HCT (fosinopril sodium-hydrochlorothiazide tablets) is indicated for the treatment of hypertension.

These fixed dose combinations are not indicated for initial therapy. (See DOSAGE AND ADMINISTRATION.)

In using MONOPRIL-HCT, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that fosinopril does not have a similar risk (see WARNINGS: Neutropenia/Agranulocytosis).

ACE inhibitors (for which adequate data are available) cause a higher rate of angioedema in black than in non-black patients (see WARNINGS: Head and Neck Angioedema and Intestinal Angioedema).


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NEWS HIGHLIGHTS

Media Articles Related to Monopril-HCT (Fosinopril / Hydrochlorothiazide)

Combination Therapy Improves Pulmonary Hypertension Outcomes
Source: Medscape Medical News Headlines [2016.05.20]
Combination therapy reduces the risk of clinical worsening in idiopathic and connective-tissue-associated pulmonary arterial hypertension better than monotherapy, according to a new meta-analysis.
Medscape Medical News

Hypertension in Pregnancy Ups Intellectual Disability, ASD Risk
Source: Medscape Psychiatry & Mental Health Headlines [2016.05.19]
Children born of mothers who have any form of hypertension during pregnancy are at elevated risk for intellectual disability and autism.
Medscape Medical News

American Society of Hypertension (ASH) 2016 Annual Scientific Meeting
Source: theheart.org | Medscape Cardiology Headlines [2016.05.17]
Read clinically focused news coverage of key developments from ASH 2016.
theheart.org on Medscape

Around-the-clock monitoring may unmask hypertension in African-Americans
Source: Hypertension News From Medical News Today [2016.05.17]
Ambulatory blood pressure monitoring, a device which measures blood pressure around-the-clock may help identify African Americans who have "masked" or undetected high blood pressure.

High Blood Pressure (Hypertension): Warning Signs, Risks, Medications
Source: MedicineNet Nosebleed Specialty [2016.05.13]
Title: High Blood Pressure (Hypertension): Warning Signs, Risks, Medications
Category: Slideshows
Created: 3/9/2011 12:10:00 PM
Last Editorial Review: 5/13/2016 12:00:00 AM

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Page last updated: 2016-05-20

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