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Mononine (Coagulation Factor IX Human) - Summary

 
 



MONONINE SUMMARY

Mononine, Coagulation Factor IX (Human), is a sterile, stable, lyophilized concentrate of Factor IX prepared from pooled human plasma and is intended for use in therapy of Factor IX deficiency, known as Hemophilia B or Christmas disease. Mononine is purified of extraneous plasma-derived proteins, including Factors II, VII and X, by use of immunoaffinity chromatography.

Mononine is indicated for the prevention and control of bleeding in Factor IX deficiency, also known as Hemophilia B or Christmas disease.

Mononine is not indicated in the treatment or prophylaxis of Hemophilia A patients with inhibitors to Factor VIII.

Mononine contains non-detectable levels of Factors II, VII and X (<0.0025 IU per Factor IX unit using standard coagulation assays) and is, therefore, not indicated for replacement therapy of these clotting factors.

Mononine is also not indicated in the treatment or reversal of coumarin-induced anticoagulation or in a hemorrhagic state caused by hepatitis-induced lack of production of liver dependent coagulation factors.


See all Mononine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Mononine (Coagulation Factor IX Human)

Surgeons Support Teaching Public to Stop Bleeding in Emergencies
Source: Medscape General Surgery Headlines [2017.05.19]
Just as many regular people have already learned CPR, members of the public can and should learn techniques to stop bleeding after mass-shooting events or everyday injuries, a survey of U.S. surgeons concludes.
Reuters Health Information

Low-cost drug reduces death due to bleeding in women with post-partum haemorrhage
Source: Pregnancy / Obstetrics News From Medical News Today [2017.04.27]
Tranexamic acid - an inexpensive and widely available drug - could reduce maternal deaths among women with severe bleeding after child birth, according to a global trial of 20,000 women in 21...

Study identifies a distinct type of common gastrointestinal bleeding
Source: Liver Disease / Hepatitis News From Medical News Today [2017.04.25]
A unique bleeding syndrome associated with cirrhosis and portal hypertension has been identified by researchers at the Medical University of South Carolina (MUSC), Wake Forest University Medical...

Vaginal Bleeding
Source: MedicineNet Ectopic Pregnancy Specialty [2017.03.24]
Title: Vaginal Bleeding
Category: Symptoms and Signs
Created: 10/13/2003 12:00:00 AM
Last Editorial Review: 3/24/2017 12:00:00 AM

Study Tracks Bleeding Risk From Common Blood Thinners
Source: MedicineNet clopidogrel Specialty [2017.03.01]
Title: Study Tracks Bleeding Risk From Common Blood Thinners
Category: Health News
Created: 2/28/2017 12:00:00 AM
Last Editorial Review: 3/1/2017 12:00:00 AM

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Published Studies Related to Mononine (Coagulation Factor IX Human)

A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial. [2011.02]
Anticoagulants are the cornerstone of current acute coronary syndrome (ACS) therapy; however, anticoagulation regimens that aggressively reduce ischemic events are almost uniformly associated with more bleeding... The objectives of RADAR are (1) to determine the safety of a range of levels of RB006 reversal with RB007 after catheterization, (2) to confirm whether a dose of 1 mg/kg RB006 results in near-complete inhibition of factor IXa in patients with ACS, and (3) to assess the efficacy of RB006 as an anticoagulant in patients with ACS undergoing percutaneous coronary intervention.

First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention. [2010.08.10]
CONCLUSIONS: This study demonstrates the clinical translation of a novel platform of anticoagulation targeting factor IXa and its active reversal to percutaneous coronary intervention and provides the basis for further investigation. CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT00715455.

Coagulation factors II, V, IX, X, XI, and XII, plasminogen, and alpha-2 antiplasmin and risk of coronary heart disease. [2010.04.30]
AIM: To examine whether plasma levels of coagulation factors II, V, IX, X, XI, and XII, plasminogen, and alpha-2 antiplasmin are associated with coronary heart disease (CHD) in a prospective case-cohort study... CONCLUSIONS: Positive associations of factors IX and XI, and alpha-2 antiplasmin with incident CHD were not strong and accounted for by classical coronary risk factors.

Effects of L-Carnitine supplement on plasma coagulation and anticoagulation factors in hemodialysis patients. [2010]
BACKGROUND: Hypercoagulability is an important risk factor for thrombosis and its complications in hemodialysis patients. This study was designed to investigate the effects of l-carnitine supplement on plasma coagulation and anticoagulation factors in hemodialysis patients... CONCLUSION: l-Carnitine supplement reduces serum CRP, a marker of systemic inflammation, and plasma fibrinogen, an inflammation-related coagulation factor, in hemodialysis patients. Therefore, l-carnitine may play an effective role in preventing cardiovascular diseases in these patients.

Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology. [2009.10.01]
Higher levels of procoagulant factors and factor XII deficiency may be risk factors for first venous thromboembolism (VTE). We studied associations of coagulation factors IX through XIII with risk of future VTE in 2 general population samples... Among these procoagulant factors, only elevated factor XI was a risk factor for VTE.

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Page last updated: 2017-05-19

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