Monodox ®
Doxycycline
Monohydrate
Capsules
Rx only
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Monodox® and other antibacterial drugs, Monodox should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
DESCRIPTION
Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. Monodox 100 mg and 50 mg capsules contain doxycycline monohydrate equivalent to 100 mg or 50 mg of doxycycline for oral administration. The chemical designation of the light-yellow crystalline powder is alpha-6-deoxy-5-oxytetracycline.
Structural formula:
 C22H24N2O8• H2O M.W.=462.45
Doxycycline has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. Doxycycline will not degrade into an epianhydro form.
Inert ingredients: colloidal silicon dioxide; hard gelatin capsule; magnesium stearate; microcrystalline cellulose; and sodium starch glycolate.
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