DOSAGE AND ADMINISTRATION
General Instructions
Carefully consider the potential benefits
and risks of MOBIC and other treatment options before deciding to
use MOBIC. Use the lowest effective dose for the shortest duration
consistent with individual patient treatment goals [
see Warnings and Precautions
].
After
observing the response to initial therapy with MOBIC, adjust the dose
to suit an individual patient's needs.
In adults, the maximum recommended daily oral dose of
MOBIC is 15 mg regardless of formulation. In patients with hemodialysis,
a maximum daily dosage of 7.5 mg is recommended [
see Warnings and Precautions , Use in Specific Populations , and Clinical Pharmacology
].
MOBIC
oral suspension 7.5 mg/5 mL or 15 mg/10 mL may be substituted for
MOBIC tablets 7.5 mg or 15 mg, respectively.
Shake the oral suspension gently before
using.
MOBIC
may be taken without regard to timing of meals.
Osteoarthritis
For the relief of the signs and symptoms
of osteoarthritis the recommended starting and maintenance oral dose
of MOBIC is 7.5 mg once daily. Some patients may receive additional
benefit by increasing the dose to 15 mg once daily.
Rheumatoid Arthritis
For the relief of the signs and symptoms
of rheumatoid arthritis, the recommended starting and maintenance
oral dose of MOBIC is 7.5 mg once daily. Some patients may receive
additional benefit by increasing the dose to 15 mg once daily.
Juvenile RheumatoidArthritis (JRA) Pauciarticular and Polyarticular Course
To improve dosing accuracy in smaller weight
children, the use of the MOBIC oral suspension is recommended. MOBIC
oral suspension is available in the strength of 7.5 mg/5 mL. For the
treatment of juvenile rheumatoid arthritis, the recommended oral dose
of MOBIC is 0.125 mg/kg once daily up to a maximum of 7.5 mg. There
was no additional benefit demonstrated by increasing the dose above
0.125 mg/kg once daily in these clinical trials.
Juvenile Rheumatoid Arthritis dosing
using the oral suspension should be individualized based on the weight
of the child:
|
0.125 mg/kg
|
Weight
|
Dose (1.5
mg/mL)
|
Delivered dose
|
12 kg (26 lb)
|
1.0 mL |
1.5 mg |
24 kg (54 lb)
|
2.0 mL |
3.0 mg |
36 kg (80 lb)
|
3.0 mL |
4.5 mg |
48 kg (106 lb)
|
4.0 mL |
6.0 mg |
≥60 kg (132 lb)
|
5.0 mL |
7.5 mg |
DOSAGE FORMS AND STRENGTHS
Tablets:
- 7.5 mg: pastel yellow, round, biconvex, uncoated tablet
containing meloxicam 7.5 mg. Impressed with the Boehringer Ingelheim
logo on one side and the letter “M” on the other.
- 15 mg: pastel yellow, oblong, biconvex, uncoated tablet
containing meloxicam 15 mg. Impressed with the tablet code “15” on
one side and the letter “M” on the other.
Oral Suspension:
- yellowish green tinged viscous suspension containing 7.5
mg meloxicam in 5 mL.
|