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Mobic (Meloxicam) - Summary

 
 



WARNING

Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS and CLINICAL TRIALS).

  • MOBIC tablets/oral suspension is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

  • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).
 

MOBIC SUMMARY

Mobic®
(meloxicam)
Tablets 7.5 mg and 15 mg
and
Mobic®
(meloxicam)
Oral Suspension 7.5 mg/5 mL

MOBIC® (meloxicam), an oxicam derivative, is a member of the enolic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Each pastel yellow tablet contains meloxicam 7.5 mg or 15 mg for oral administration.

MOBIC is indicated for relief of the signs and symptoms of osteoarthritis.


See all Mobic indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Mobic (Meloxicam)

Comparison of meloxicam and a glucosamine-chondroitin supplement in management of feline osteoarthritis. A double-blind randomised, placebo-controlled, prospective trial. [2014]
(Glu-Ch) supplement in the management of feline osteoarthritis (OA)... CONCLUSIONS: Treatment with meloxicam resulted in a significant improvement in

Pharmacokinetics and safety of oral administration of meloxicam to foals. [2013]
BACKGROUND: The pharmacokinetics, efficacy, and safety of meloxicam have been evaluated in adult horses, but not foals. Physiologic differences between neonates and adults might alter drug pharmacokinetics and therapeutic index... In contrast to findings for other NSAIDs, foals appeared more resilient to the adverse effects of this drug than was observed in adult horses.

Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a prospective, randomised clinical trial. [2012]
One hundred female cats undergoing routine ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia were included in a blinded, randomised, prospective clinical study to compare postoperative analgesia produced by four analgesic drug combinations given preoperatively (n = 25 per group)...

A randomized, single-blind comparison of the efficacy and tolerability of hyaluronate acid and meloxicam in adult patients with Kashin-Beck disease of the knee. [2012]
The aim of this study was to prospectively evaluate the efficacy and tolerability of hyaluronic acid (HA) and meloxicam for the treatment of knee pain due to Kashin-Beck disease (KBD). A total of 162 patients with KBD-based knee pain were randomly assigned to treatment with a 3-week course of HA (n = 80) and a 12-week course of meloxicam (n = 82)...

Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. [2011.04]
The aim of this study was to evaluate the efficacy and palatability of meloxicam 0.5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders. This single blinded, positively-controlled, randomised, multicentre trial involved 121 client owned cats...

more studies >>

Clinical Trials Related to Mobic (Meloxicam)

The BE Study of Meloxicam GSK 15mg (BA/BE 250/12-117176) [Not yet recruiting]
It is a randomized, balanced, open label, crossover, two period, two treatment, two sequence, single dose, oral bioequivalence study of Meloxicam GSK 15 mg tablets manufactured by Savipharm J. S.Cc, Vietnam and Mobic« 15 mg tablets of Boehringer Ingelheim Pharma GmbH & Co. KG Binger Str. 173, 5521 Ingelheim am Rhein, Germany, in healthy, adult, human male subjects under fed condition. It is a pivotal study to demonstrate the bioequivalence of Meloxicam GSK 15 mg tablets manufactured by Savipharm J. S.C, Vietnam and Mobic┬« 15 mg tablets of Boehringer Ingelheim Pharma GmbH & Co. KG Binger Str. 173, 5521 Ingelheim am Rhein, Germany, in healthy adult human male subjects under fed condition.

This study will enroll 28 healthy adult human male subjects

Food Study of Meloxicam Tablets 15 mg and Mobic« Tablets 15┬ámg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's meloxicam 15 mg tablets and Boehringer Ingelheim's Mobic« 15 mg tablets following a single, oral 15 mg (1 x 15 mg) dose administration under fed conditions.

Fasting Study of Meloxicam Tablets 15 mg and Mobic« Tablets 15┬ámg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's meloxicam 15 mg tablets and Boehringer Ingelheim's Mobic« 15 mg tablets following a single, oral 15 mg (1 x 15 mg) dose administration under fasting conditions.

Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee [Recruiting]
This study is to validate the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) tool in mainland Chinese patients with osteoarthritis of the knee . This study will also evaluate the effects of Mobic versus placebo on reducing the symptoms of osteoarthritis in this population.

A Study to Compare Meloxicam IM Once Daily vs. Meloxicam Orally Once Daily in Patients With Rheumatoid Arthritis [Completed]
The objective of this trial was to assess the efficacy and safety of 15 mg meloxicam i. m. once daily compared with 15 mg meloxicam tablets once daily p. o. in patients with Rheumatoid arthritis over a time period of 7 days.

more trials >>

Reports of Suspected Mobic (Meloxicam) Side Effects

Anaemia (27)Drug Ineffective (19)Dyspnoea (18)Renal Failure Acute (17)Arthralgia (16)Pain (15)Diplopia (15)Abdominal Pain (14)Constipation (14)Decreased Appetite (14)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 26 ratings/reviews, Mobic has an overall score of 6.15. The effectiveness score is 6.69 and the side effect score is 7.54. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Mobic review by 63 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Arthritis
Dosage & duration:   20 mg taken once a day for the period of Months
Other conditions:   Asthma
Other drugs taken:   Serevent, Singulaire
  
Reported Results
Benefits:   Pain reduction, increased mobility and range of motion. The difference between how I feel with and without Mobic is astonishing. Unfortunately, if I take this drug for more than six months straight, it begins to lose effectiveness. Thus, I now save it for situations where I absolutely need it: travel, sports, etc.
Side effects:   None. My only complaint is that it loses effectiveness when taken over a period of time.
Comments:   Took once a day, always with food to protect my stomach.

 

Mobic review by 65 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   arthritis/knee pain
Dosage & duration:   7.5mg taken i daily for the period of 2 years to date
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   quite effective without the adverse effects of aspirin, naproxin etc. because of the reported side effects of cox2 meds i take as little as possible to maintain a reletively comfortable exixtence
Side effects:   only side effect was sore tummy on the odd occasion i took it without food
Comments:   i take 1x 7.5 tablet every other day plus omega 3/6/9 and halibut liver oil caps and walk as much as possible. I only resort to 1 tablet daily if knee is really bad. 15mg daily and i am pain free but i am not prepared to risk the side effects on an otherwise healthy body

 

Mobic review by 80 year old male patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   severe back pain
Dosage & duration:   7.5 mg daily taken bid for the period of not started
Other conditions:   polymyalgia rheumatica
Other drugs taken:   prednisone requip klonopin prilosec zoloft
  
Reported Results
Benefits:   None yet
Side effects:   None...YET
Comments:   After reading these reviews, I'm afraid of even starting this drug even with doctor's Rx. of t.5 mg daily. Occasionally very effective but below average I think. Why run tge risk of some of the horrible side effects, e.g. stomach surgery. No thanks. I'll take my prednisone!!

See all Mobic reviews / ratings >>

Page last updated: 2014-12-01

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