WARNING
Cardiovascular Risk
- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS and CLINICAL TRIALS).
- MOBIC tablets/oral suspension is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
Gastrointestinal Risk
- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).
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MOBIC SUMMARY
Mobic®
(meloxicam)
Tablets 7.5 mg and 15 mg
and
Mobic®
(meloxicam)
Oral Suspension 7.5 mg/5 mL
MOBIC® (meloxicam), an oxicam derivative, is a member of the enolic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Each pastel yellow tablet contains meloxicam 7.5 mg or 15 mg for oral administration.
MOBIC is indicated for relief of the signs and symptoms of osteoarthritis.
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NEWS HIGHLIGHTS
Published Studies Related to Mobic (Meloxicam)
Comparison of tepoxalin, carprofen, and meloxicam for reducing intraocular inflammation in dogs. [2009.07]
OBJECTIVE: To compare effects of orally administered tepoxalin, carprofen, and meloxicam for controlling aqueocentesis-induced anterior uveitis in dogs, as determined by measurement of aqueous prostaglandin E(2) (PGE(2)) concentrations.Tepoxalin may be an appropriate choice when treating dogs with anterior uveitis.
Effects of meloxicam on plasma iohexol clearance as a marker of glomerular filtration rate in conscious healthy cats. [2009.07]
OBJECTIVE: To investigate the effect of therapeutic dosages of meloxicam on the plasma clearance of iohexol in healthy, euvolemic, conscious cats fed a sodium-replete diet...
Bioequivalence studies of two brands of meloxicam tablets in healthy Pakistani volunteers. [2009.04]
The pharmacokinetic parameters of two oral formulations of meloxicam tablets were compared in a randomized, single oral dose; two treatments cross over design in 12 healthy male volunteers belonging to Pakistan under fasting conditions. After an overnight fast, the volunteers received 30 mg meloxicam and the blood samples were collected up to 96 hours and drug concentrations were determined by a validated HPLC method...
A randomized, double-blind, controlled trial of perioperative administration of gabapentin, meloxicam and their combination for spontaneous and movement-evoked pain after ambulatory laparoscopic cholecystectomy. [2009.02]
BACKGROUND: Hysterectomy and spinal surgery inpatient trials suggest favorable interactions between cyclooxgenase-2 inhibitors and gabapentin/pregabalin on postoperative days 1-2. We present the first trial of meloxicam-gabapentin combination after outpatient laparoscopic cholecystectomy... CONCLUSION: Although nausea was reduced with combination therapy, this trial provides little or no support for the combined use of meloxicam and gabapentin for pain relief on the day of surgery. This suggests that perioperative analgesic polypharmacy may not always be necessary or appropriate.
Comparison of the efficacy and safety of a novel meloxicam ophthalmic formulation with a reference diclofenac solution in cataract surgery. [2009.02]
A novel topical ophthalmic formulation of the preferential COX-2 inhibitor meloxicam has recently been developed. The purpose of the present study was to evaluate the efficacy and safety of this novel 0.03% meloxicam solution with regard to a reference 0.1% diclofenac formulation in a prospective, parallel, randomized, multicenter, double-blind study...
Clinical Trials Related to Mobic (Meloxicam)
Food Study of Meloxicam Tablets 15 mg and Mobic® Tablets 15Â mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's meloxicam 15 mg
tablets and Boehringer Ingelheim's Mobic® 15 mg tablets following a single, oral 15 mg (1 x
15 mg) dose administration under fed conditions.
Fasting Study of Meloxicam Tablets 15 mg and Mobic® Tablets 15Â mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's meloxicam 15 mg
tablets and Boehringer Ingelheim's Mobic® 15 mg tablets following a single, oral 15 mg (1 x
15 mg) dose administration under fasting conditions.
A Study to Compare Meloxicam IM Once Daily vs. Meloxicam Orally Once Daily in Patients With Rheumatoid Arthritis [Completed]
The objective of this trial was to assess the efficacy and safety of 15 mg meloxicam i. m.
once daily compared with 15 mg meloxicam tablets once daily p. o. in patients with Rheumatoid
arthritis over a time period of 7 days.
A Study to Compare Meloxicam IM Once Daily and Meloxicam Administered Orally Once Daily in Patients With Osteoarthritis [Completed]
The objective of this trial was to assess the efficacy and safety of 7. 5 mg meloxicam i. m.
once daily compared with 7. 5 mg meloxicam tablets once daily p. o. in patients with
osteoarthritis over a time period of 7 days.
A Study of Meloxicam [Mobic] in Juvenile Rheumatoid Arthritis (JRA) [Completed]
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 11 ratings/reviews, Mobic has an overall score of 5.18. The effectiveness score is 4.91 and the side effect score is 7.09. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Mobic review by 79 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | inflamation 10 years after surgery |
| Dosage & duration: | | 15mg taken once a day for the period of 1 month |
| Other conditions: | | elevated cholesterol |
| Other drugs taken: | | 5 mg Crestor, daily | | |
Reported Results |
| Benefits: | | !0 years after spinal stenosis, scar-tissue and additional narrowing of nerve canals causes sever inflammation and pain. My back pain is virtually disappeared, I feel like a new kid on the block |
| Side effects: | | Constant chancre sores in the mouth. "Tanac" helps |
| Comments: | | I take one 15 mg Mobic with dinner. I have nothing else to add |
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| | Mobic review by 55 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Ineffective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | neck pain from car accident whiplash |
| Dosage & duration: | | 7.5mg tablet taken twice a day for the period of 1 week |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | Hard to judge whether or not it was actually reducing the inflammation. I was taking it while undergoing physical therapy which seemed at times to exacerbate the pain from the whiplash. |
| Side effects: | | Even though I took Mobic as directed with food and/or milk, it made me extremely nauseous, which was more debilitating to me than the whiplash pain I was experiencing. I stopped taking it after 1 week and was immediately no longer experiencing nausea. |
| Comments: | | My dotor precribed this for treatment of whiplash follwing a car accident.I was doing physical therapy exercises twice a week and taking 1 Mobic pill, 2X daily with food. |
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| | Mobic review by 44 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | back pain |
| Dosage & duration: | | 15 mg taken daily for the period of 1 week |
| Other conditions: | | none |
| Other drugs taken: | | Zanaflex at night | | |
Reported Results |
| Benefits: | | No impact whatsoever. It was like I wasn't even taking anything. The OTC ibuprofen I was taking before my doctor appointment was more effective. |
| Side effects: | | None. Seriously, I could not even tell I had taken a drug, there were no impacts whatsover, either positive or negative. |
| Comments: | | Took 2 tablets (15 mg) total, once daily in the morning. Also took Zanaflex, but only at night. The Zanaflex helped - for about 3 hours. When I was just on the meloxicam, I was in terrible pain. The injury being treated was mid-back pain, caused by straining/overusing my back muscles in a ski competition. I have a 30 day prescription for meloxicam, but I'm calling the doctor tomorrow to ask for something different; this drug is totally pointless for me. |
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Page last updated: 2009-10-20
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