Moban (Molindone Hydrochloride) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

Drug Interactions

Potentiation of drugs administered concurrently with MOBAN has not been reported. Additionally, animal studies have not shown increased toxicity when MOBAN is given concurrently with representative members of three classes of drugs (i.e., barbiturates, chloral hydrate and antiparkinson drugs).

OVERDOSAGE

Symptomatic, supportive therapy should be the rule.

Gastric lavage is indicated for the reduction of absorption of MOBAN which is freely soluble in water.
Since the adsorption of MOBAN by activated charcoal has not been determined, the use of this antidote must be considered of theoretical value.

Emesis in a comatose patient is contraindicated. Additionally, while the emetic effect of apomorphine is blocked by MOBAN in animals, this blocking effect has not been determined in humans.

A significant increase in the rate of removal of unmetabolized MOBAN from the body by forced diuresis, peritoneal or renal dialysis would not be expected. (Only 2% of a single ingested dose of MOBAN is excreted unmetabolized in the urine). However, poor response of the patient may justify use of these procedures.

While the use of laxatives or enemas might be based on general principles, the amount of unmetabolized MOBAN in feces is less than 1%. Extrapyramidal symptoms have responded to the use of Diphenhydramine (Benadryl^®)^*, Amantadine HCl (Symmetrel^®)^† and the synthetic anticholinergic antiparkinson agents, (i.e., Artane^®‡, Cogentin^®§, Akineton^®¶).

CONTRAINDICATIONS

MOBAN is contraindicated in severe central nervous system depression (alcohol, barbiturates, narcotics, etc.) or comatose states, and in patients with known hypersensitivity to the drug.