MIVACRON SUMMARY
MIVACRON® Injection
(mivacurium chloride)
MIVACRON (mivacurium chloride) is a short-acting, nondepolarizing skeletal muscle relaxant for intravenous (IV) administration. Mivacurium chloride is [ R -[ R *, R *-(E)]]-2,2'-[(1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)]
bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]
isoquinolinium] dichloride.
MIVACRON is a short-acting neuromuscular blocking agent indicated for inpatients and outpatients, as an adjunct to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
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NEWS HIGHLIGHTSMedia Articles Related to Mivacron (Mivacurium)
Patients With Sleep Apnea Undergoing Joint Replacement Have Improved Outcomes With Regional Anesthesia
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.07]
Using regional anesthesia instead of general anesthesia in patients with sleep apnea undergoing total joint replacement decreases major complications by 17%, according to a study published online, ahead of print, in the journal Regional Anesthesia and Pain Medicine...
Lower Rates Of Complications In Hip And Knee Replacement Using Regional Anesthesia Technique
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.03]
A highly underutilized anesthesia technique called neuraxial anesthesia, also known as spinal or epidural anesthesia, improves outcomes in patients undergoing hip or knee replacement, according to a new study by researchers at Hospital for Special Surgery...
General Anesthesia Not Linked to Raised Risk for Dementia
Source: MedicineNet Dementia Specialty [2013.05.02]
Title: General Anesthesia Not Linked to Raised Risk for Dementia
Category: Health News
Created: 5/1/2013 12:35:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM
Success Rates Of Turning Breech Babies Increased By Anesthesia, Delivery Costs Reduced
Source: Pain / Anesthetics News From Medical News Today [2013.04.22]
When a baby is in the breech position at the end of pregnancy, obstetricians can sometimes turn the baby head-down to enable a safer vaginal birth. In the past, women were not given anesthesia during the turning procedure, which requires the physician to push on the woman's abdomen while monitoring the baby with ultrasound...
Development Of Wisdom Teeth In Children May Be Affected By Dental Anesthesia
Source: Dentistry News From Medical News Today [2013.04.05]
Researchers from Tufts University School of Dental Medicine have discovered a statistical association between the injection of local dental anesthesia given to children ages two to six and evidence of missing lower wisdom teeth...
Published Studies Related to Mivacron (Mivacurium)
Pharmacodynamic evaluation of augmentation effect of isoflurane on mivacurium. [2009.06]
This study evaluated the augmentation effect of isoflurane (ISO) given before or after the mivacurium (MIV) injection. Consented 33 adults (18-58 years), ASA I patients of both sexes were randomly assigned into three groups...
A comparison of intubation conditions and time-course of action with rocuronium and mivacurium for day case anaesthesia. [2007.06]
BACKGROUND AND OBJECTIVE: To compare intubation conditions and time-course of action of rocuronium and mivacurium for day case anaesthesia... CONCLUSIONS: There is no significant difference between mivacurium and rocuronium concerning the onset and the recovery of muscle relaxation. Rocuronium is an alternative to mivacurium for short procedures, without the risk of unexpected prolonged relaxation due to a possible defect in plasma cholinesterase.
Premedication for nonemergent neonatal intubations: a randomized, controlled trial comparing atropine and fentanyl to atropine, fentanyl, and mivacurium. [2006.10]
OBJECTIVE: The purpose of this work was to investigate whether using a muscle relaxant would improve intubation conditions in infants, thereby decreasing the incidence and duration of hypoxia and time and number of attempts needed to successfully complete the intubation procedure... CONCLUSIONS: Premedication with atropine, fentanyl, and mivacurium compared with atropine and fentanyl without a muscle relaxant decreases the time and number of attempts needed to successfully intubate while significantly reducing the incidence of severe desaturation. Premedication including a short-acting muscle relaxant should be considered for all nonemergent intubations in the NICU.
[Interaction between mivacurium and succinylcholine from a different point of view] [2006.03]
OBJECTIVES: Succinylcholine (SCH) may first be used and continue with mivacurium (MIV). MIV has been suggested as a pretreatment. Conflicting results arises from studies on SCH-MIV interaction. The following trial revisits this interaction... CONCLUSIONS: When mivacurium is used before the effects of succinylcholine disappear, a residual effect is not usually taken into consideration. This study corrected MAX and calculated speed of action, demonstrating a reduction in net block and speed of action, consistent with an antagonistic action when the 2 blockers are administered sequentially.
Xenon does not modify mivacurium induced neuromuscular block: [Le xenon ne modifie pas le bloc neuromusculaire induit par le mivacurium]. [2005.11]
PURPOSE: The interaction between mivacurium and inhaled anesthetics is known, with the exception of xenon. We compared the pharmacodynamics of mivacurium during xenon anesthesia vs total iv anesthesia with propofol... CONCLUSION: We conclude that the neuromuscular blocking effects of mivacurium are similar when given during propofol vs xenon anesthesia.
Clinical Trials Related to Mivacron (Mivacurium)
Influence of Premedication Protocols for Neonatal Endotracheal Intubation on Cerebral Oxygenation [Recruiting]
The purpose of this study is to examine the influence of premedication drugs Atropin,
Fentanyl and Mivacurium and of endotracheal intubation on cerebral oxygenation and cardiac
output in term and preterm newborn infants. Two different protocols of premedication are
compared.
Effect of Deep BLock on Intraoperative Surgical Conditions [Recruiting]
Rationale: A deep neuromuscular block is often associated with improved surgical conditions
especially in laparoscopic surgery. However, a deep block comes at the expense of a variety
of items that may conflict with the use of a deep surgical muscle blockade including a long
recovery phase, the need for muscle reversal, postoperative ventilation, impaired
postoperative breathing. With the introduction of Sugammadex there is now the possibility to
reverse an even deep surgical block. This may overcome most if not all of the issues
mentioned.
Objective: To assess whether a deep neuromuscular block provides better surgical conditions
than a moderately deep block as derived from a surgical rating score.
Study design: Single center, double-blind randomized controlled trial. Study population: 24
ASA I-III patients scheduled for laparoscopic renal (n=12, GROUP 1) or prostatic surgery
(n=12, GROUP 2).
Intervention: In both GROUP 1 and GROUP 2, 6 six patients will receive neuromuscular
blockade according to current practice (atracurium (bolus) plus mivacurium (cont. infusion))
aimed at a moderately deep neuromuscular block (1-2 twitches in the Train of Four (TOF)
monitor). The other six will receive a bolus plus continuous infusion with rocuronium aimed
at a deep neuromuscular block (1-2 twitches post tetanic count (PTC)). All surgical
procedures will be performed by one surgeon.
Main study parameters/endpoints: To study the surgical conditions in patients undergoing
laparoscopic renal or prostate surgery during deep versus less deep neuromuscular block as
assessed by the surgical rating score.
Nature and extent of the burden and risks associated with participation, benefit and group
relatedness: Compared to current practice there will be no additional risk.
Affect of Different Types of Anesthetic Techniques on Cognition in Patients With Parkinson's Disease [Recruiting]
Parkinson's disease is a common progressive degenerative disease affecting 3% of all
patients over the age of 65. Given their age and frailty, these patients frequently require
surgical procedures with general anesthesia. However, after surgery, patients with
Parkinson's disease have longer hospital stays and a greater chance of not returning to
independent living compared to age-matched controls (Berman MF, unpublished data). In part,
this is due to a higher rate of post-operative delirium, which had an incidence of 60% in
this population in one study. There is anecdotal evidence from neurologists specializing in
movement disorder suggesting that there is also significant deterioration in parkinsonian
motor symptoms and cognition lasting for months or years following surgery and anesthesia.
The basis for this deterioration is unknown. We hypothesize that these problems are caused
by particular medications used during inhaled anesthesia for surgical procedures.
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