MIVACRON (mivacurium chloride) is a short-acting, nondepolarizing skeletal muscle relaxant for intravenous (IV) administration. Mivacurium chloride is [ R -[ R *, R *-(E)]]-2,2'-[(1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)]
MIVACRON is a short-acting neuromuscular blocking agent indicated for inpatients and outpatients, as an adjunct to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Media Articles Related to Mivacron (Mivacurium)
Scientists find what might be responsible for slow heart function under general anesthesia
Source: Cardiovascular / Cardiology News From Medical News Today [2016.05.13]
New research in The FASEB Journal suggests that general anesthesia targets certain amino acids on proteins of the heart muscle fibers and cells which directly affects the ability of the heart to pump.
A 'communication breakdown' during general anesthesia
Source: Pain / Anesthetics News From Medical News Today [2016.05.12]
It's a topic that has long captivated doctors, scientists and the public -- what exactly happens in your brain when you're oblivious on the operating table?
Conscious Sedation Same as Anesthetic for Stroke Thrombectomy
Source: Medscape Anesthesiology Headlines [2016.05.19]
SIESTA, the first randomized trial comparing general anesthesia and conscious sedation, has shown similar short-term outcomes in stroke patients undergoing endovascular treatment.
Medscape Medical News
Noninvasive monitor assesses patients' response to painful stimulation during surgery
Source: Medical Devices / Diagnostics News From Medical News Today [2016.05.16]
A novel measure for assessing the body's response to surgery may allow for better anesthesia management in the O.R.
How do anesthesiologists view acupuncture and acupressure?
Source: Anxiety / Stress News From Medical News Today [2016.05.05]
In a new study of anesthesia providers in the U.S., most report not having used or received any education in acupuncture or acupressure.
Published Studies Related to Mivacron (Mivacurium)
Pharmacodynamic evaluation of augmentation effect of isoflurane on mivacurium. [2009.06]
This study evaluated the augmentation effect of isoflurane (ISO) given before or after the mivacurium (MIV) injection. Consented 33 adults (18-58 years), ASA I patients of both sexes were randomly assigned into three groups...
A comparison of intubation conditions and time-course of action with rocuronium and mivacurium for day case anaesthesia. [2007.06]
BACKGROUND AND OBJECTIVE: To compare intubation conditions and time-course of action of rocuronium and mivacurium for day case anaesthesia... CONCLUSIONS: There is no significant difference between mivacurium and rocuronium concerning the onset and the recovery of muscle relaxation. Rocuronium is an alternative to mivacurium for short procedures, without the risk of unexpected prolonged relaxation due to a possible defect in plasma cholinesterase.
Premedication for nonemergent neonatal intubations: a randomized, controlled trial comparing atropine and fentanyl to atropine, fentanyl, and mivacurium. [2006.10]
OBJECTIVE: The purpose of this work was to investigate whether using a muscle relaxant would improve intubation conditions in infants, thereby decreasing the incidence and duration of hypoxia and time and number of attempts needed to successfully complete the intubation procedure... CONCLUSIONS: Premedication with atropine, fentanyl, and mivacurium compared with atropine and fentanyl without a muscle relaxant decreases the time and number of attempts needed to successfully intubate while significantly reducing the incidence of severe desaturation. Premedication including a short-acting muscle relaxant should be considered for all nonemergent intubations in the NICU.
[Interaction between mivacurium and succinylcholine from a different point of view] [2006.03]
OBJECTIVES: Succinylcholine (SCH) may first be used and continue with mivacurium (MIV). MIV has been suggested as a pretreatment. Conflicting results arises from studies on SCH-MIV interaction. The following trial revisits this interaction... CONCLUSIONS: When mivacurium is used before the effects of succinylcholine disappear, a residual effect is not usually taken into consideration. This study corrected MAX and calculated speed of action, demonstrating a reduction in net block and speed of action, consistent with an antagonistic action when the 2 blockers are administered sequentially.
Xenon does not modify mivacurium induced neuromuscular block: [Le xenon ne modifie pas le bloc neuromusculaire induit par le mivacurium]. [2005.11]
PURPOSE: The interaction between mivacurium and inhaled anesthetics is known, with the exception of xenon. We compared the pharmacodynamics of mivacurium during xenon anesthesia vs total iv anesthesia with propofol... CONCLUSION: We conclude that the neuromuscular blocking effects of mivacurium are similar when given during propofol vs xenon anesthesia.
Clinical Trials Related to Mivacron (Mivacurium)
Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis [Recruiting]
Observed the muscle relaxation of mivacurium in patients with liver cirrhosis. Clear of
mivacurium in patients with liver cirrhosis without muscle relaxant accumulation and delayed
Sex-related Differences in the Response to the Muscle Relaxant Drug Mivacurium [Completed]
Muscle relaxants are drugs providing muscle relaxation during surgical treatment. Previous
studies have shown that males and females respond differently to this kind of drug. Our
hypothesis is that males are more sensitive to the effect of Mivacurium (a muscle relaxant)
than females, meaning that males need a lower blood concentration of the drug than females
in order to obtain a given effect.
A Prospective, Multi-center, Randomized Controlled Study of Muscle Relaxation Effect and Safety of Mivacurium Chloride in Pediatric Surgery Patients [Completed]
Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy [Completed]
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as
rigid bronchoscopy. A alternative is the application of low dose mivacurium, reversed with
neostigmine. The investigators compare the intubating conditions, incidence of postoperative
myalgia (POM), patient satisfaction and the postoperative performance with respiration
exercise device for these two muscle relaxants.
Influence of Premedication Protocols for Neonatal Endotracheal Intubation on Cerebral Oxygenation [Completed]
The purpose of this study is to examine the influence of premedication drugs Atropin,
Fentanyl and Mivacurium and of endotracheal intubation on cerebral oxygenation and cardiac
output in term and preterm newborn infants. Two different protocols of premedication are