MIRAPEX tablets contain pramipexole, a nonergot dopamine agonist.
MIRAPEX tablets are indicated for the treatment of the signs and symptoms of idiopathic Parkinson's disease.
Restless Legs Syndrome
MIRAPEX tablets are indicated for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS).
Media Articles Related to Mirapex (Pramipexole)
New study surveys genetic changes linked with Parkinson's disease
Source: Genetics News From Medical News Today [2016.05.26]
After Alzheimer's, Parkinson's disease (PD) is the leading neurodegenerative disorder, affecting close to a million Americans, with 50,000 new cases diagnosed every year.
The effects of laxatives may provide new clues concerning Parkinson's disease
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today [2016.05.19]
In a recent retrospective analysis, investigators discovered that the year-on-year increase in rigidity found in Parkinson's disease flattened off with the regular use of laxatives to manage...
Transplanted nerve cells survive a quarter of a century in a Parkinson's disease patient
Source: Transplants / Organ Donations News From Medical News Today [2016.05.04]
In the late 1980s and over the 1990s, researchers at Lund University in Sweden pioneered the transplantation of new nerve cells into the brains of patients with Parkinson's disease.
Parkinson's disease: New insights into a traveling protein
Source: CJD / vCJD / Mad Cow Disease News From Medical News Today [2016.01.05]
A laboratory study indicates that one of the main proteins involved in Parkinson's disease pathology does not behave as a 'prion' In Parkinson's disease, the protein "alpha-synuclein" aggregates...
Parkinson's Disease Quiz: Test Your Medical IQ
Source: MedicineNet amantadine Specialty [2015.02.20]
Title: Parkinson's Disease Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 8/23/2011 12:53:00 PM
Last Editorial Review: 2/20/2015 4:38:06 PM
Published Studies Related to Mirapex (Pramipexole)
Comparison of pregabalin with pramipexole for restless legs syndrome. 
alternative... CONCLUSIONS: Pregabalin provided significantly improved treatment outcomes as
Pregabalin versus pramipexole: effects on sleep disturbance in restless legs
reducing restless legs syndrome (RLS)-related sleep disturbance... CONCLUSIONS: This study demonstrated improvements in objective and subjective
Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis
(EMPOWER): a randomised, double-blind, phase 3 trial. 
phase 3 trial of patients with familial or sporadic disease... INTERPRETATION: Dexpramipexole was generally well tolerated but did not differ
Pramipexole in patients with early Parkinson's disease (PROUD): a randomised
delayed-start trial. 
with Parkinson's disease (PD)... INTERPRETATION: By clinical and neuroimaging measures, pramipexole showed little
Role and clinical utility of pramipexole extended release in the treatment of
early Parkinson's disease. 
The aim of this article is to provide a short review of the most relevant
pharmacological and clinical data on pramipexole extended release (ER) as well as
to address the clinical utility and potential advantages of a once-daily
formulation especially in the treatment of early Parkinson's disease (PD)...
Clinical Trials Related to Mirapex (Pramipexole)
Pramipexole as a Treatment for Cocaine Dependence [Completed]
The purposes of this study are as follows: 1. To assess the cardiovascular and subjective
effects of cocaine during treatment with pramipexole and placebo. 2. To assess the
reinforcing effects of cocaine, measured using choice procedures, during treatment with
pramipexole and placebo.
Pramipexole for Binge Eating Disorder [Withdrawn]
Study to Observe the Effect of Mirapex ERŪ Once-daily (QD) Versus Twice-daily (BID) [Recruiting]
1. In order to observe the benefit, side effects, and patient preference of Mirapex ER
when used in once-daily (QD) or twice-daily (BID) dosing
2. In order to estimate the conversion rate of dopamine agonists into Mirapex ER
Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) [Completed]
This is a 2-part study of KNS-760704 in patients with ALS.
- Part 1 is a randomized, placebo-controlled, multi-center study to evaluate the safety,
tolerability, and clinical effects of oral administration of 3 dosage levels of KNS
760704 vs. placebo for 12 weeks.
- Part 2 is a randomized, double-blind, 2-arm, parallel group, extension study evaluating
the safety, tolerability, and clinical effects of oral administration of 2 dosage
levels of KNS-760704 for up to 76 weeks.
Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211) [Completed]
This is an open-label, multi-center study designed to extend the evaluation of the safety,
tolerability, and clinical effects of oral administration of KNS-760704 in patients with
Reports of Suspected Mirapex (Pramipexole) Side Effects
Obsessive-Compulsive Disorder (99),
Pathological Gambling (99),
Emotional Distress (84),
Compulsive Shopping (44),
Suicidal Ideation (31),
Hyperphagia (19), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 6 ratings/reviews, Mirapex has an overall score of 7. The effectiveness score is 9 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Mirapex review by 53 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || Restless Leg Syndrome|
|Dosage & duration:|| || 100 mg at bedtime taken daily for the period of ongoing|
|Other conditions:|| || high blood pressure; heartburn|
|Other drugs taken:|| || toprol xl; nexium|
|Benefits:|| || First treatment in 50 years that helped the constant but elusive pain in my nervous system, causing me to sleep an hour or two at a time at best. The pain is 100% gone when I take the mirapex ... back when I do not.|
|Side effects:|| || Can fall asleep at my desk or driving without much notice. Reduced the amount I was taking from 200 mg to the 100mg.|
|Comments:|| || I take it at bedtime nightly.|
Mirapex review by 50 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Marginally Effective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || pain in legs (diagnosis Restless Leg Syndrome)|
|Dosage & duration:|| || 50 mg taken 1 time per day for the period of 1 month|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || I had been to several doctors regarding pain in my thigh mostly. I had seen Orthopedic Dr, Family practice (2), Endocrinologist and finally Nuerologist, who prescribed the Mirapex. I did note slight improvement in leg pain however the weight gain issue was totally unacceptable to me and the benefit was only slight. I have had much better results with Lyrica.|
|Side effects:|| || Basically, I only noticed a huge weight gain of approximately 15 pounds. I do not really recall any further side effects. There were however, other side effects listed on the prescription contraindication form. I do not recall what the side effects listed on that form were now. |
|Comments:|| || he Doctor told me to take he medication at bed time each evening. she also suggested that I might find it useful to sleep with a contour pillow between my thighs. She said to get up and walk around rather than lie in bed tossing if I could not sleep. As for the weight gain, it was recommended that I try to excercise more and reduce caloric intake.|
Mirapex review by medical professional caring for 50 year old male patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Extremely Severe Side Effects|
|Condition / reason:|| || Parkinson's|
|Dosage & duration:|| || 0.125 mg taken 1 x day for the period of 5 years|
|Other conditions:|| || HBV, HCV, opiate & cocaine addictions DIRECTLY pursuant to Pramipexole use|
|Other drugs taken:|| || Sinemet/Levodopa, Amantadine, Diphenhydramine, beer (Rx by neurologist), heroin & crack (self Rx) |
|Benefits:|| || Mirapex: tremor control|
|Side effects:|| || Mirapex: impulse control absence, induction of OCD symptoms, drug addiction (heroin, crack, etc.) and hepatitis B & C all pursuant to massive sexual and substance risk taking behaviors, loss of professional license, theft of $1million of clients' funds, gambled EVERYTHING away, lost everything, began inappropriate sexual relationships with prostitutes in home town and in Central America as well as with underaged females (who were often teenaged crack addicts), theft of EVERY SINGLE ITEM of any value from his extremely elderly wealthy father and from the rest of us, left crack in our young adult daughter's car, severing of relationships: WE have to protect ourselves from him and his evil-Mirapex reactions|
|Comments:|| || Subsequently: he got DBS implanted and has been able to reduce the Mirapex - BUT THE DAMAGE IS DONE|
Page last updated: 2016-05-26