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Mirapex (Pramipexole Dihydrochloride) - Summary

 
 



MIRAPEX SUMMARY

MIRAPEX tablets contain pramipexole, a nonergot dopamine agonist.

Parkinson's Disease

MIRAPEX tablets are indicated for the treatment of the signs and symptoms of idiopathic Parkinson's disease.

Restless Legs Syndrome

MIRAPEX tablets are indicated for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS).


See all Mirapex indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Mirapex (Pramipexole)

Parkinson's Disease
Source: MedicineNet Amyotrophic Lateral Sclerosis Specialty [2016.08.09]
Title: Parkinson's Disease
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/9/2016 12:00:00 AM

Cancer Drug Shows Early Promise for Parkinson's Disease
Source: MedicineNet Leukemia Specialty [2016.07.13]
Title: Cancer Drug Shows Early Promise for Parkinson's Disease
Category: Health News
Created: 7/12/2016 12:00:00 AM
Last Editorial Review: 7/13/2016 12:00:00 AM

Donated Blood Won't Transmit Alzheimer's, Parkinson's Disease
Source: MedicineNet Blood Transfusion Specialty [2016.06.28]
Title: Donated Blood Won't Transmit Alzheimer's, Parkinson's Disease
Category: Health News
Created: 6/27/2016 12:00:00 AM
Last Editorial Review: 6/28/2016 12:00:00 AM

Parkinson's Disease: Symptoms, Causes, Stages, and Treatment
Source: MedicineNet Tremor Specialty [2016.06.01]
Title: Parkinson's Disease: Symptoms, Causes, Stages, and Treatment
Category: Slideshows
Created: 8/16/2011 6:25:00 PM
Last Editorial Review: 6/1/2016 12:00:00 AM

Transplanted nerve cells survive a quarter of a century in a Parkinson's disease patient
Source: Transplants / Organ Donations News From Medical News Today [2016.05.04]
In the late 1980s and over the 1990s, researchers at Lund University in Sweden pioneered the transplantation of new nerve cells into the brains of patients with Parkinson's disease.

more news >>

Published Studies Related to Mirapex (Pramipexole)

Comparison of pregabalin with pramipexole for restless legs syndrome. [2014]
alternative... CONCLUSIONS: Pregabalin provided significantly improved treatment outcomes as

Pregabalin versus pramipexole: effects on sleep disturbance in restless legs syndrome. [2014]
reducing restless legs syndrome (RLS)-related sleep disturbance... CONCLUSIONS: This study demonstrated improvements in objective and subjective

Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial. [2013]
phase 3 trial of patients with familial or sporadic disease... INTERPRETATION: Dexpramipexole was generally well tolerated but did not differ

Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial. [2013]
with Parkinson's disease (PD)... INTERPRETATION: By clinical and neuroimaging measures, pramipexole showed little

Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease. [2012]
The aim of this article is to provide a short review of the most relevant pharmacological and clinical data on pramipexole extended release (ER) as well as to address the clinical utility and potential advantages of a once-daily formulation especially in the treatment of early Parkinson's disease (PD)...

more studies >>

Clinical Trials Related to Mirapex (Pramipexole)

Pramipexole as a Treatment for Cocaine Dependence [Completed]
The purposes of this study are as follows: 1. To assess the cardiovascular and subjective effects of cocaine during treatment with pramipexole and placebo. 2. To assess the reinforcing effects of cocaine, measured using choice procedures, during treatment with pramipexole and placebo.

Pramipexole for Binge Eating Disorder [Withdrawn]

Study to Observe the Effect of Mirapex ERŪ Once-daily (QD) Versus Twice-daily (BID) [Recruiting]
1. In order to observe the benefit, side effects, and patient preference of Mirapex ER when used in once-daily (QD) or twice-daily (BID) dosing 2. In order to estimate the conversion rate of dopamine agonists into Mirapex ER

Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) [Completed]
This is a 2-part study of KNS-760704 in patients with ALS.

- Part 1 is a randomized, placebo-controlled, multi-center study to evaluate the safety,

tolerability, and clinical effects of oral administration of 3 dosage levels of KNS 760704 vs. placebo for 12 weeks.

- Part 2 is a randomized, double-blind, 2-arm, parallel group, extension study evaluating

the safety, tolerability, and clinical effects of oral administration of 2 dosage levels of KNS-760704 for up to 76 weeks.

Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211) [Completed]
This is an open-label, multi-center study designed to extend the evaluation of the safety, tolerability, and clinical effects of oral administration of KNS-760704 in patients with ALS.

more trials >>

Reports of Suspected Mirapex (Pramipexole) Side Effects

Obsessive-Compulsive Disorder (99)Pathological Gambling (99)Emotional Distress (84)Pain (83)Compulsive Shopping (44)Suicidal Ideation (31)Hypersexuality (30)Depression (30)Somnolence (27)Hyperphagia (19)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 6 ratings/reviews, Mirapex has an overall score of 7. The effectiveness score is 9 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Mirapex review by 53 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Restless Leg Syndrome
Dosage & duration:   100 mg at bedtime taken daily for the period of ongoing
Other conditions:   high blood pressure; heartburn
Other drugs taken:   toprol xl; nexium
  
Reported Results
Benefits:   First treatment in 50 years that helped the constant but elusive pain in my nervous system, causing me to sleep an hour or two at a time at best. The pain is 100% gone when I take the mirapex ... back when I do not.
Side effects:   Can fall asleep at my desk or driving without much notice. Reduced the amount I was taking from 200 mg to the 100mg.
Comments:   I take it at bedtime nightly.

 

Mirapex review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   pain in legs (diagnosis Restless Leg Syndrome)
Dosage & duration:   50 mg taken 1 time per day for the period of 1 month
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I had been to several doctors regarding pain in my thigh mostly. I had seen Orthopedic Dr, Family practice (2), Endocrinologist and finally Nuerologist, who prescribed the Mirapex. I did note slight improvement in leg pain however the weight gain issue was totally unacceptable to me and the benefit was only slight. I have had much better results with Lyrica.
Side effects:   Basically, I only noticed a huge weight gain of approximately 15 pounds. I do not really recall any further side effects. There were however, other side effects listed on the prescription contraindication form. I do not recall what the side effects listed on that form were now.
Comments:   he Doctor told me to take he medication at bed time each evening. she also suggested that I might find it useful to sleep with a contour pillow between my thighs. She said to get up and walk around rather than lie in bed tossing if I could not sleep. As for the weight gain, it was recommended that I try to excercise more and reduce caloric intake.

 

Mirapex review by medical professional caring for 50 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   Parkinson's
Dosage & duration:   0.125 mg taken 1 x day for the period of 5 years
Other conditions:   HBV, HCV, opiate & cocaine addictions DIRECTLY pursuant to Pramipexole use
Other drugs taken:   Sinemet/Levodopa, Amantadine, Diphenhydramine, beer (Rx by neurologist), heroin & crack (self Rx)
  
Reported Results
Benefits:   Mirapex: tremor control
Side effects:   Mirapex: impulse control absence, induction of OCD symptoms, drug addiction (heroin, crack, etc.) and hepatitis B & C all pursuant to massive sexual and substance risk taking behaviors, loss of professional license, theft of $1million of clients' funds, gambled EVERYTHING away, lost everything, began inappropriate sexual relationships with prostitutes in home town and in Central America as well as with underaged females (who were often teenaged crack addicts), theft of EVERY SINGLE ITEM of any value from his extremely elderly wealthy father and from the rest of us, left crack in our young adult daughter's car, severing of relationships: WE have to protect ourselves from him and his evil-Mirapex reactions
Comments:   Subsequently: he got DBS implanted and has been able to reduce the Mirapex - BUT THE DAMAGE IS DONE

See all Mirapex reviews / ratings >>

Page last updated: 2016-08-09

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