NEWS HIGHLIGHTS
Published Studies Related to Miralax (Polyethylene Glycol 3350)
Reduced cathartic bowel preparation for CT colonography: prospective comparison of 2-L polyethylene glycol and magnesium citrate. [2011.10]
PURPOSE: To prospectively compare adequacy of colonic cleansing, adequacy of solid stool and fluid tagging, and patient acceptance by using reduced-volume, 2-L polyethylene glycol (PEG) versus magnesium citrate bowel preparations for CT colonography... CONCLUSION: Reduced-volume PEG and magnesium citrate bowel preparations demonstrated adequate cleansing effectiveness for CT colonography, with better tagging and shorter interpretation time observed in the PEG group. Adequate polyp detection was maintained but requires further validation because of the small number of clinically important polyps. (c) RSNA, 2011.
Effect of bowel preparation with polyethylene glycol on quality of capsule endoscopy. [2011.06]
BACKGROUND AND AIMS: Capsule endoscopy (CE) has the problem that lumen visualization is impaired by bubbles, bile, and debris. The benefits of bowel preparation are still controversial and the best method remains to be determined. The objective of this study was to evaluate the effect of the method of bowel preparation on the quality of visualization and on transit time... CONCLUSIONS: Bowel preparation with PEG resulted in better image quality than fasting alone. No significant difference was observed between 2 and 4 l. PEG 2 l rather than 4 l may be a useful method of preparation for CE.
MiraLAX is not as effective as GoLytely in bowel cleansing before screening colonoscopies. [2011.04]
BACKGROUND & AIMS: Successful colonoscopies require good bowel preparations-poor bowel preparations can increase medical costs, rates of missed lesions, and procedure duration. The combination of polyethylene glycol (PEG) 3350 without electrolytes (MiraLAX; Schering-Plough Healthcare Products, Inc, Kenilworth, NJ) and 64 oz of Gatorade (PepsiCo, Inc, Purchase, NY) has gained popularity as a bowel preparation regimen. However, the efficacy and tolerability of this approach has not been compared with standard bowel preparations in clinical trials. We compared split-dose (PEG) 3350 with electrolytes (GoLytely; Braintree Laboratories, Inc, Braintree, MA) with split-dose MiraLAX alone and in combination with pretreatment medications (bisacodyl or lubiprostone) to determine the efficacy and patient tolerability of MiraLAX as an agent for bowel preparation... CONCLUSIONS: Split-dose MiraLAX in 64 oz of Gatorade is not as effective as 4 L split-dose GoLytely in bowel cleansing for screening colonoscopies. Copyright (c) 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
Low-volume bowel preparation is inferior to standard 4 1 polyethylene glycol. [2011.03]
BACKGROUND: Four liters or more of orally taken polyethylene glycol solution (PEG) has proved to be an effective large-bowel cleansing method prior to colonoscopy. The problem has been the large volume of fluid and its taste, which is unacceptable to some examinees. We aimed to investigate the effectiveness of 2 l PEG combined with senna compared with 4 l PEG for bowel preparation... CONCLUSIONS: 4 l PEG treatment is better than 36 mg senna and 2 l PEG as routine colonic cleansing before colonoscopy because of fewer failures.
Comparison of the effectiveness of polyethylene glycol 4000 without electrolytes and magnesium hydroxide in the treatment of chronic functional constipation in children. [2011.01]
OBJECTIVE: To compare the effectiveness of two drugs, polyethylene glycol 4000 without electrolytes and magnesium hydroxide, in the treatment of chronic functional constipation in children... CONCLUSION: The two laxatives showed no difference in effectiveness for the treatment of constipation. However, due to its better acceptance, because it is odorless and tasteless, polyethylene glycol proved to be a better option for treating chronic functional constipation.
Clinical Trials Related to Miralax (Polyethylene Glycol 3350)
Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy [Recruiting]
A major limitation to the widespread acceptance of colonoscopy as a procedure to screen for
colorectal cancer is the laxative preparation. Phosphate-based preps (e. g. Fleets
Phosphosoda) are now used on a limited basis because of their known association with renal
injury. Polyethylene glycol (PEG) mixed with a balanced electrolyte solution (e. g. Golytely)
has been used for over two decades for colon cleansing. The mixture is not very palatable
due to the electrolyte additives which include sodium sulfate.
To overcome the limitation of existing preps, gastroenterologists and colorectal surgeons
worldwide have been using PEG powder alone (same quantity as found in Golytely prep) not
mixed with electrolytes (Glycolax or Miralax) and dissolving this into 64 ounces of
Gatorade. Conservatively, we estimate that 25% of colonoscopies in the US are being done
with this prep. Anecdotally there have been reports (case series) that it is far more
palatable and the prep is equally efficacious. The active ingredient, PEG, is not changed
and therefore this is not surprising. The issue at present is that there has never been a
blinded study to confirm these claims.
This study will compare the efficacy of the two preps. There is no funding. The
investigators will charge insurance companies for the prep - this is our current practice.
The procedures will be done on healthy individuals referred for colon cancer screening and
the exam will be billed to their insurance. There will be no patient honorarium. The
investigators will check electrolytes to be sure patients do not develop hypokalemia with
the Gatorade prep.
A Trial Comparing Split-Dose Miralax With Amitiza Pretreatment Versus Dulcolax Pretreatment for Bowel Cleansing Prior to Colonoscopy [Recruiting]
Miralax (PEG 3350) has been shown to be a safe and uncomplicated bowel preparation prior to
colonoscopy in pediatric populations. This study seeks to confirm the efficacy of this bowel
cleansing regimen in adults and to determine the benefit of adding a pretreatment medication
to this bowel preparation. The tolerability of Miralax will hopefully improve patient
satisfaction with colonoscopy and decrease their reluctance to be screened because of the
uncomfortable taste and side effects of bowel preparation regimens.
MiraLAX Versus Placebo to Prevent Constipation Following Urogynecologic Surgery [Recruiting]
A. Purpose To compare MiraLAX versus placebo for preventing constipation in the immediate
postoperative period following pelvic reconstructive surgery in women taking routine
docusate sodium.
B. Objectives
1. Specific Aims Specific Aim 1: To compare time to first bowel movement (BM) between
MiraLAX versus placebo in women receiving routine docusate sodium after pelvic
reconstructive surgery.
Specific Aim 2: To compare patient reported outcomes of BM quality and associated
gastrointestinal (GI) symptoms between MiraLAX versus placebo using the Bristol stool
scale and the validated Patient Assessment of Constipation Symptom Questionnaire
(PAC-SYM) in women receiving routine docusate sodium after pelvic reconstructive
surgery.
Specific Aim 3: To evaluate GI-related quality of life between MiraLAX versus placebo
utilizing the validated Patient Assessment of Constipation Quality-of-Life
Questionnaire (PAC-QOL) in women receiving routine docusate sodium after pelvic
reconstructive surgery.
2. Hypotheses The investigators hypothesize that MiraLAX will optimally prevent
constipation following pelvic reconstructive surgery by decreasing time to first BM,
decreasing GI symptoms associated with constipation, and increasing measures of
GI-related quality of life, while minimizing the bothersome side effects associated
with stimulant laxatives.
A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely [Not yet recruiting]
Prior to colonoscopies, the colon is cleansed using a laxative. Golytely is approved by the
FDA for this purpose. Another laxative, called MiraLax, is approved by the FDA to relieve
constipation, but it is not approved specifically for preparation for a colonoscopy.
Nonetheless, it is commonly used in clinical practice for this purpose, just as is Golytely.
The purpose of this study is to compare Golytely and MiraLax in two ways: to see whether one
is better tolerated by patients than the other and to see whether one more effectively
cleanses the bowel than the other. The investigators' hypothesis is that these 2 bowel
preparation methods are equally effective in bowel cleansing, but that patients prefer
Miralax to Golytely.
A Study Comparing PEG-3350 (Miralax) and Gatorade With PEG-ELS (Golytely) for Bowel Preparation Prior to Colonoscopy [Recruiting]
The purpose of this study to to see how well Miralax (PEG-3350) and Gatorade cleans the
colon before a colonoscopy and how easy it is to take compared to Golytely (PEG-ELS) bowel
preparation solution. Another purpose is to see if taking half of the bowel preparation
solution on the evening before the colonoscopy and half on the morning of the colonoscopy
will result in a cleaner colon than taking all of the bowel preparation solution on the
evening before.
Reports of Suspected Miralax (Polyethylene Glycol 3350) Side Effects
Drug Ineffective (81),
Incorrect Drug Administration Duration (76),
Overdose (51),
Diarrhoea (32),
Drug Administered TO Patient of Inappropriate AGE (23),
OFF Label USE (22),
Drug Effect Decreased (17),
Flatulence (16),
Abdominal Distension (16),
Dysgeusia (16), more >>
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