NEWS HIGHLIGHTS
Published Studies Related to Miralax (Polyethylene Glycol 3350)
A Randomized, Double-Blind, Placebo-Controlled Trial of Polyethylene Glycol Effects on Fasting and Postprandial Rectal Sensitivity and Symptoms in Hypersensitive Constipation-Predominant Irritable Bowel Syndrome. [2009.07.03]
Objective: To assess the effect of polyethylene glycol 3350 (PEG) on fasting and postprandial (PP) perception of rectal distension and symptoms in hypersensitive constipation-predominant irritable bowel syndrome (IBS-C)...
Differences in taste between two polyethylene glycol preparations. [2007.12]
BACKGROUND AND AIMS: Polyethylene glycol preparations (PEG) are increasingly used for chronic constipation in both adults and children. There are some suggestions that PEG 4000 with orange flavour (Forlax) tastes better than PEG 3350 which contains salt (Movicolon). Poor taste is an important factor for non-compliance and is one of the leading causes of therapy failure. The aim of the study was to compare the taste of two commonly used PEG preparations, PEG 4000 and PEG 3350... CONCLUSION: PEG 4000 tastes better than PEG 3350. This may have implications for patient compliance and effectiveness of treatment in patients with chronic constipation.
Polyethylene glycol 3350 plus electrolytes for chronic constipation in children: a double blind, placebo controlled, crossover study. [2007.11]
OBJECTIVES: To assess the efficacy and safety of polyethylene glycol 3350 plus electrolytes (PEG+E) for the treatment of chronic constipation in children... CONCLUSIONS: PEG+E is significantly more effective than placebo, and appears to be safe and well tolerated in the treatment of chronic constipation in children.
A randomized, multicenter, placebo-controlled trial of polyethylene glycol laxative for chronic treatment of chronic constipation. [2007.07]
OBJECTIVES: Polyethylene glycol (PEG) 3350 (MiraLAX) is currently approved for the short-term treatment of occasional constipation. This study was designed to compare the safety and efficacy of PEG laxative versus placebo over a 6-month treatment period in patients with chronic constipation... CONCLUSIONS: PEG laxative is safe and effective for use in patients with chronic constipation for 6 months.
A Randomized, Multicenter, Placebo-Controlled Trial of Polyethylene Glycol Laxative for Chronic Treatment of Chronic Constipation. [2007.03.31]
OBJECTIVES: Polyethylene glycol (PEG) 3350 (MiraLAX) is currently approved for the short-term treatment of occasional constipation. This study was designed to compare the safety and efficacy of PEG laxative versus placebo over a 6-month treatment period in patients with chronic constipation... CONCLUSIONS: PEG laxative is safe and effective for use in patients with chronic constipation for 6 months.
Clinical Trials Related to Miralax (Polyethylene Glycol 3350)
A Trial Comparing Split-Dose Miralax With Amitiza Pretreatment Versus Dulcolax Pretreatment for Bowel Cleansing Prior to Colonoscopy [Recruiting]
Miralax (PEG 3350) has been shown to be a safe and uncomplicated bowel preparation prior to
colonoscopy in pediatric populations. This study seeks to confirm the efficacy of this bowel
cleansing regimen in adults and to determine the benefit of adding a pretreatment medication
to this bowel preparation. The tolerability of Miralax will hopefully improve patient
satisfaction with colonoscopy and decrease their reluctance to be screened because of the
uncomfortable taste and side effects of bowel preparation regimens.
A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely [Not yet recruiting]
Prior to colonoscopies, the colon is cleansed using a laxative. Golytely is approved by the
FDA for this purpose. Another laxative, called MiraLax, is approved by the FDA to relieve
constipation, but it is not approved specifically for preparation for a colonoscopy.
Nonetheless, it is commonly used in clinical practice for this purpose, just as is Golytely.
The purpose of this study is to compare Golytely and MiraLax in two ways: to see whether one
is better tolerated by patients than the other and to see whether one more effectively
cleanses the bowel than the other. The investigators' hypothesis is that these 2 bowel
preparation methods are equally effective in bowel cleansing, but that patients prefer
Miralax to Golytely.
A Pilot Study of a New MiraLax® Dose Formulation For Use in Constipated Children [Completed]
To evaluate patient acceptance of a new MiraLax dose formulation in children currently
treated with polyethylene glycol 3350 powder for treatment of constipation.
Comparison Trial of Enema vs. PEG 3350 for Constipation [Recruiting]
The purpose of this study is to determine if milk and molasses enema or PEG 3350 works
better for treatment of fecal impaction in children who are constipated.
PolyethyleneGlycol3350 Laxative Vs Placebo in Constipated Children [Completed]
Assess the safety and efficacy of polyethyleneglycol3350 laxative as compared to placebo
therapy in pediatric patients with a history of constipation.
|
