solution, USP 0.01%
MIOSTAT® (carbachol intraocular solution, USP) is a sterile balanced salt solution of carbachol for intraocular injection.
Miostat (carbachol OPHTHALMIC) is indicated for the following:
Intraocular use for obtaining miosis during surgery. In addition, MIOSTAT (carbachol intraocular solution, USP) reduces the intensity of intraocular pressure elevation in the first 24 hours after cataract surgery.
Published Studies Related to Miostat (Carbachol Ophthalmic)
Investigation of carbachol and PACAP38 in a human model of migraine. [2010.12]
The parasympathetic signalling molecules acetylcholine, pituitary adenylate cyclase activating peptide-38 (PACAP38) and vasoactive intestinal peptide (VIP) may be released from parasympathetic fibres and activate sensory nerve fibres during migraine attacks.The present thesis contributes to our knowledge on migraine pathophysiology and suggests PAC1 receptor antagonism as a new target for migraine treatment.
Dietary phytoestrogens maintain contractile responses to carbachol with age in the female rat isolated bladder. [2011.08.15]
AIMS: Development of urinary incontinence, for many women, occurs following menopause. Dietary phytoestrogens consumed over the long term may affect the contractile function and maintenance of the urinary bladder in post menopausal women... SIGNIFICANCE: These results suggest an age-related reduction in the contractile response of the detrusor to the muscarinic receptor agonist carbachol, which may be prevented by long term dietary phytoestrogen intake.
Carbachol alleviates rat cytokine release and organ dysfunction induced by lipopolysaccharide. [2011.07]
BACKGROUND: To observe the influence of carbachol on inflammatory cytokine release and its protective role on organ function in rat endotoxemia model, and, furthermore, to investigate its receptor mechanism in rat peritoneal macrophages in vitro... CONCLUSION: The results suggested that both carbachol and nicotine play a role in the anti-inflammatory process and organ function protection through the alpha7 subunit of nicotinic cholinergic receptor.
Hypothalamic disconnection caudal to paraventricular nucleus affects cardiovascular and drinking responses to central angiotensin II and carbachol. [2011.05.04]
The paraventricular nucleus of the hypothalamus (PVN) is an important area of the brain involved in the control of cardiovascular system and fluid-electrolyte balance. In the present study we evaluated the effects of hypothalamic disconnection (HD) caudal to PVN in the pressor and dipsogenic responses induced by intracerebroventricular (icv) injections of angiotensin II (ANG II) or carbachol (cholinergic agonist).
Carbachol promotes gastrointestinal function during oral resuscitation of burn shock. [2011.04.07]
AIM: To investigate the effect of carbachol on gastrointestinal function in a dog model of oral resuscitation for burn shock... CONCLUSION: Carbachol had a beneficial effect on oral resuscitation of burn shock by promoting gastric emptying and intestinal absorption in our canine model.
Clinical Trials Related to Miostat (Carbachol Ophthalmic)
Carbachols Headache-Inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients [Recruiting]
The purpose of this study is to test if carbachol infusion induces headache in migraine
subjects as well as intra- and extra-cerebral vasodilatation.
Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow [Completed]
Reports of Suspected Miostat (Carbachol Ophthalmic) Side Effects
Toxic Anterior Segment Syndrome (7),
Medication Error (6),
Visual Acuity Reduced (2),
Intraocular Pressure Increased (1),
Anterior Chamber Fibrin (1),
Anterior Chamber Pigmentation (1),
Flat Anterior Chamber of Eye (1),
Conjunctival Bleb (1),
Conjunctival Oedema (1),
Corneal Opacity (1), more >>