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Miochol-E (Acetylcholine Chloride) - Summary

 

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MIOCHOL-E SUMMARY

Miochol®-E

Miochol ® -E (acetylcholine chloride intraocular solution) is a parasympathomimetic preparation for intraocular use. It is packaged in a blister pack containing one vial and one ampoule. The vial contains 20 mg acetylcholine chloride and 56 mg mannitol. The accompanying ampoule contains 2 mL of a modified diluent of sodium acetate trihydrate, potassium chloride, magnesium chloride hexahydrate, calcium chloride dihydrate and sterile water for injection. The reconstituted liquid will be a sterile isotonic solution (275-330 milliosmoles/Kg) containing 20 mg acetylcholine chloride (1:100 solution) and 2.8% mannitol. The pH range is 5.0-8.2. Mannitol is used in the process of lyophilizing acetylcholine chloride, and is not considered an active ingredient.

Miochol-E (acetylcholine) is indicated for the following:

To obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

MIOCHOL-E NEWS HIGHLIGHTS

Published Studies Related to Miochol-E (Acetylcholine)

Nicotinic acetylcholine receptor {beta}2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. [2008.07.01]

M2 and M3-muscarinic acetylcholine receptors remodelling in patients with a dilated atrium. [2008.04]

Efficacy and tolerability of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, in a 12-week, randomized, placebo-controlled, dose-response study with 40-week follow-up for smoking cessation in Japanese smokers. [2007.06]

A randomized, placebo-controlled trial of varenicline, a selective alpha4beta2 nicotinic acetylcholine receptor partial agonist, as a new therapy for smoking cessation in Asian smokers. [2007.06]

Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI). [2007.03]

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Clinical Trials Related to Miochol-E (Acetylcholine)

Clonidine-Induced Spinal Acetylcholine Release: Normal Volunteers vs. Neuropathic Pain [Recruiting]

Adenosine Receptors Influence Ischemia-Reperfusion Injury [Suspended]

Microvascular Reactivity. [Completed]

Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia [Completed]

Recombinant Human Superoxide Dismutase (rhSOD) and Vascular Reactivity [Completed]

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Page last updated: 2008-08-11

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