Mintezol (Thiabendazole) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

Drug Interactions

Thiabendazole may compete with other drugs, such as theophylline, for sites of metabolism in the liver, thus elevating the serum levels of such compounds to potentially toxic levels. Therefore, when concomitant use of thiabendazole and xanthine derivatives is anticipated, it may be necessary to monitor blood levels and/or reduce the dosage of such compounds. Such concomitant use should be administered under careful medical supervision.

OVERDOSAGE

Overdosage may be associated with transient disturbances of vision and psychic alterations.

There is no specific antidote in the event of overdosage. Therefore, symptomatic and supportive measures should be employed. Emesis should be induced or gastric lavage performed carefully.

The oral LD₅₀ of MINTEZOL is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit, respectively.

CONTRAINDICATIONS

Hypersensitivity to this product.

Thiabendazole is contraindicated as prophylactic treatment for pinworm infestation.