Mintezol (Thiabendazole) - Indications and Dosage

INDICATIONS AND USAGE

MINTEZOL is indicated for the treatment of:

• Strongyloidiasis (threadworm)

• Cutaneous larva migrans (creeping eruption)

• Visceral larva migrans

Trichinosis: Relief of symptoms and fever and a reduction of eosinophilia have followed the use of MINTEZOL during the invasion stage of the disease.

Thiabendazole is usually inappropriate as first line therapy for enterobiasis (pinworm). However, when enterobiasis occurs with any of the conditions listed above, additional therapy is not required for most patients.

MINTEZOL should be used only in the following infestations when more specific therapy is not available or cannot be used or when further therapy with a second agent is desirable: Uncinariasis (hookworm: Necator americanus and Ancylostoma duodenale); Trichuriasis (whipworm); Ascariasis (large roundworm).

DOSAGE AND ADMINISTRATION

The recommended maximum daily dose of MINTEZOL is 3 grams.

MINTEZOL should be given after meals if possible. Tablets MINTEZOL should be chewed before swallowing. Dietary restriction, complementary medications and cleansing enemas are not needed.

The usual dosage schedule for all conditions is two doses per day. The dosage is determined by the patient's weight.

A weight-dose chart follows:

Weight	Each Dose
	g	mL
30 lb	0.25 (½ tablet)	2.5 (½ teaspoon)
50 lb	0.5 (1 tablet)	5.0 (1 teaspoon)
75 lb	0.75 (1½ tablets)	7.5 (1½ teaspoons)
100 lb	1.0 (2 tablets)	10.0 (2 teaspoons)
125 lb	1.25 (2½ tablets)	12.5 (2½ teaspoons)
150 lb & over	1.5 (3 tablets)	15.0 (3 teaspoons)

The regimen for each indication follows:

Therapeutic Regimens
Indication	Regimen	Comments
1 STRONGYLOIDIASIS	2 doses per day for 2 successive days.	A single dose of 20 mg/lb or 50 mg/kg may be employed as an alternative schedule, but a higher incidence of side effects should be expected.
CUTANEOUS LARVA MIGRANS (Creeping Eruption)	2 doses per day for 2 successive days.	If active lesions are still present 2 days after completion of therapy, a second course is recommended.
VISCERAL LARVA MIGRANS	2 doses per day for 7 successive days.	Safety and efficacy data on the seven-day treatment course are limited.
TRICHINOSIS	2 doses per day for 2-4 successive days according to the response of the patient.	The optimal dosage for the treatment of trichinosis has not been established.
Other Indications   Intestinal roundworms   (including Ascariasis,   Uncinariasis and   Trichuriasis)	2 doses per day for 2 successive days.	A single dose of 20 mg/lb or 50 mg/kg may be employed as an alternative schedule, but a higher incidence of side effects should be expected.

HOW SUPPLIED

No. 3331 — MINTEZOL Suspension, 500 mg per 5 mL, is white to off-white and is supplied as follows:

NDC 0006-3331-60 in bottles of 120 mL

(6505-00-935-5835, 0.5 g/5 mL, 120 mL).

Storage

Store in a well-closed container at controlled room temperature [15-30°C (59-86°F)]. Protect from freezing .

No. 3332 — MINTEZOL Chewable Tablets, 500 mg, are white to off-white, orange-flavored, round, scored, compressed tablets, coded MSD 907 on one side and MINTEZOL on the other.

They are supplied as follows:

NDC 0006-0907-36 unit dose packages of 36

(6505-01-226-9909, 500 mg chewable, individually sealed 36's).