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Minoxidil (Minoxidil) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

1. Salt and Water Retention (see WARNINGS: Concomitant use of Adequate Diuretic is Required) — Temporary edema developed in 7% of patients who were not edematous at the start of therapy.

2. Pericarditis, Pericardial Effusion and Tamponade (see WARNINGS).

3. DermatologicHypertrichosis — Elongation, thickening, and enhanced pigmentation of fine body hair are seen in about 80% of patients taking minoxidil tablets. This develops within 3 to 6 weeks after starting therapy. It is usually first noticed on the temples, between the eyebrows, between the hairline and the eyebrows, or in the side-burn area of the upper lateral cheek, later extending to the back, arms, legs, and scalp. Upon discontinuation of minoxidil, new hair growth stops, but 1 to 6 months may be required for restoration to pretreatment appearance. No endocrine abnormalities have been found to explain the abnormal hair growth; thus, it is hypertrichosis without virilism. Hair growth is especially disturbing to children and women and such patients should be thoroughly informed about this effect before therapy with minoxidil is begun.

Allergic — Rashes have been reported, including rare reports of bullous eruptions, and Stevens-Johnson Syndrome.

4. Hematologic — Thrombocytopenia and leukopenia (WBC<3000/mm3) have rarely been reported.

5. Gastrointestinal — Nausea and/or vomiting has been reported. In clinical trials the incidence of nausea and vomiting associated with the underlying disease has shown a decrease from pretrial levels.

6. Miscellaneous — Breast tenderness — This developed in less than 1 % of patients.

7. Altered Laboratory Findings(a) ECG changes — Changes in direction and magnitude of the ECG T-waves occur in approximately 60% of patients treated with minoxidil. In rare instances a large negative amplitude of the T-wave may encroach upon the S-T segment, but the S-T segment is not independently altered. These changes usually disappear with continuance of treatment and revert to the pretreatment state if minoxidil is discontinued. No symptoms have been associated with these changes, nor have there been alterations in blood cell counts or in plasma enzyme concentrations that would suggest myocardial damage. Long-term treatment of patients manifesting such changes has provided no evidence of deteriorating cardiac function. At present the changes appear to be nonspecific and without identifiable clinical significance. (b) Effects of hemodilution — hematocrit, hemoglobin and erythrocyte count usually fall about 7% initially and then recover to pretreatment levels. (c) Other — Alkaline phosphatase increased varyingly without other evidence of liver or bone abnormality. Serum creatinine increased an average of 6% and BUN slightly more, but later declined to pretreatment levels.



REPORTS OF SUSPECTED MINOXIDIL SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Minoxidil. The information is not vetted and should not be considered as verified clinical evidence.

Possible Minoxidil side effects / adverse reactions in 52 year old female

Reported by a consumer/non-health professional from United States on 2011-10-04

Patient: 52 year old female weighing 97.5 kg (214.5 pounds)

Reactions: Breast Cancer, OFF Label USE, Pruritus, Amenorrhoea, Wrong Drug Administered, Hypotension, Alopecia, Hair Colour Changes

Suspect drug(s):
Rogaine (For Women)
    Administration route: Topical

Rogaine Extra Strength (For Men)
    Dosage: 1/2 capful or less 1-2x a day then every other day.
    Administration route: Topical
    Indication: Alopecia
    Start date: 2011-01-01

Rogaine (For Women)
    Dosage: recommended dosage, 2 times per day, morning and night.
    Administration route: Topical
    Indication: Alopecia
    Start date: 2009-01-01

Minoxidil
    Indication: Alopecia
    End date: 2011-01-01

Rogaine Extra Strength (For Men)
    Administration route: Topical

Other drugs received by patient: Fish OIL; Estrogenic Substance; Biotin; Multi-Vitamins; Vitamin B-12; Crestor; Lisinopril; Metformin HCL; Adderall 5; Lipitor; Xanax



Possible Minoxidil side effects / adverse reactions in 43 year old male

Reported by a physician from Brazil on 2011-10-13

Patient: 43 year old male

Reactions: Blood Pressure Increased, Renal Disorder, Nausea, Visual Impairment, Left Ventricular Hypertrophy, Headache

Suspect drug(s):
Atenolol
    Dosage: 100 mg day
    Indication: Hypertension

Lorazepam

Diovan
    Dosage: 320 mg day
    Indication: Hypertension

Methyldopa
    Dosage: 1500 mg,daily
    Indication: Hypertension

Imipramine

Hygroton
    Dosage: 25 mg, day
    Indication: Hypertension

Amlodipine
    Indication: Hypertension

Clonidine
    Dosage: 300 mg, unk
    Indication: Hypertension

Spironolactone
    Dosage: 25 mg,daily
    Indication: Hypertension

Minoxidil
    Dosage: 10 mg day
    Indication: Hypertension



Possible Minoxidil side effects / adverse reactions in 43 year old male

Reported by a individual with unspecified qualification from Brazil on 2011-10-13

Patient: 43 year old male

Reactions: Blood Pressure Increased, Renal Disorder, Nausea, Heart Rate Increased, Visual Impairment, Left Ventricular Hypertrophy, Headache

Suspect drug(s):
Spironolactone
    Dosage: 25 mg,daily
    Indication: Hypertension

Hygroton
    Dosage: 25 mg, day
    Indication: Hypertension

Amlodipine
    Indication: Hypertension

Imipramine

Minoxidil
    Dosage: 10 mg day
    Indication: Hypertension

Lorazepam

Atenolol
    Dosage: 100 mg day
    Indication: Hypertension

Diovan
    Dosage: 320 mg day
    Indication: Hypertension

Methyldopa
    Dosage: 1500 mg,daily
    Indication: Hypertension

Clonidine
    Dosage: 300 mg, unk
    Indication: Hypertension



See index of all Minoxidil side effect reports >>

Drug label data at the top of this Page last updated: 2014-07-17

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