Media Articles Related to Minoxidil
Diet Effects Debated in Intracranial Hypertension
Source: Medscape Ophthalmology Headlines [2015.02.27]
Does acetazolamide improve symptoms of intracranial hypertension by lowering cerebrospinal fluid pressure, or does it work by increasing weight loss?
Medscape Medical News
Source: MedicineNet Fainting Specialty [2015.02.19]
Title: Pulmonary Hypertension
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/19/2015 12:00:00 AM
"Danger" molecule may be new therapeutic target for male hypertension
Source: Hypertension News From Medical News Today [2015.02.17]
Higher levels of a "danger" molecule may be one reason males tend to become hypertensive earlier and more severely than females, scientists say.
Pregnancy associated hypertension linked to an increased frequency of subsequent hypertension and metabolic syndrome
Source: Hypertension News From Medical News Today [2015.02.04]
In a study to be presented on Feb. 5 in an oral concurrent session at 2:45 p.m.
New hypertension guidelines could save lives and money
Source: Hypertension News From Medical News Today [2015.01.30]
Increased treatment of severe hypertension particularly cost-effectiveFull implementation of new hypertension guidelines could prevent 56,000 cardiovascular disease events (mostly heart attacks...
Published Studies Related to Minoxidil
Randomized clinical trial comparing 5% and 1% topical minoxidil for the treatment of androgenetic alopecia in Japanese men. [2009.08]
Minoxidil is efficacious in inducing hair growth in patients with androgenetic alopecia by inducing hair follicles to undergo transition from the early to late anagen phase... Our findings confirmed the superiority of 5% topical minoxidil to 1% topical minoxidil in treating Japanese men with androgenetic alopecia.
A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. [2007.11]
BACKGROUND: An alternative to currently marketed topical minoxidil solutions is desirable. OBJECTIVE: To assess the efficacy and safety of a new 5% minoxidil topical formulation in a propylene glycol-free foam vehicle in men with androgenetic alopecia (AGA)... CONCLUSIONS: We believe that 5% MTF is a safe and effective treatment for men with AGA.
A randomized, placebo-controlled trial of 1% topical minoxidil solution in the treatment of androgenetic alopecia in Japanese women. [2007.01]
Minoxidil is effective in inducing hair growth in patients with androgenetic alopecia by stimulating hair follicles to undergo transition from early to late anagen phase. However, there have been no controlled studies of topical minoxidil in Asian women... The patients tolerated treatment with 1% topical minoxidil well without significant adverse effects.
K+ channel activation with minoxidil stimulates nasal-epithelial ion transport and blunts exaggerated hypoxic pulmonary hypertension. [2006.03]
Increased pulmonary capillary pressure and inhibition of alveolar Na+ transport putatively contribute to the formation of pulmonary edema in alveolar hypoxia such as at high altitude. Since both events might be linked to the inhibition of K+ channels, we studied whether in vivo application of minoxidil, a stimulator of ATP-gated K channels (K+ ATP channel activator) prevents both effects...
Treatment of anal fissures using a combination of minoxidil and lignocaine: a randomized, double-blind trial. [2005.07]
AIM : Anal fissures are associated with hypertonia of the internal anal sphincter and pain. We evaluated the efficacy of local application of a combination of minoxidil and lignocaine in healing anal fissures... CONCLUSION: Combination treatment with minoxidil and lignocaine helps in faster healing of anal fissures and provides better symptomatic relief than either drug alone.
Clinical Trials Related to Minoxidil
Clinical Trial in Females With Female Pattern Hair Loss [Recruiting]
This is a year-long clinical trial to evaluate the effectiveness and safety in women with
Female Pattern Hair Loss (FPHL), comparing a new 5% minoxidil topical foam (MTF) formulation
applied once a day versus the 2% minoxidil topical solution (MTS) applied twice a day.
This clinical trial will use a standard measurement called Target Area Hair Count (TAHC) to
evaluate if there is a change in the number of hairs in the area being examined after using
the product for 24 weeks (and also after using the product for 12 Weeks).
This trial will determine if the benefit of using either study product outweighs the risks.
Efficacy of Minoxidil in Children With Williams-Beuren Syndrome [Recruiting]
The Williams-Beuren syndrome (WBS) is a sporadic congenital disorder characterized by a
multisystem developmental impairment. This syndrome is caused by a microdeletion in
chromosome 7q11. 23 that encompasses loss of the elastin locus.
Elastin, which is part of the extracellular matrix, controls proliferation of vascular
smooth muscle cells (VSMCs) and stabilizes arterial structure. Loss of elastin gene in WBS
patients has been claimed to provide a biological basis for the abnormal elastic fibre
properties leading to cardiovascular abnormalities like supravalvular aortic stenosis
(SVAS), hypertension, arteriosclerosis and stenosis in more than 50% of WBS children.
These cardiovascular pathologies result in important consequences and neither curative nor
preventive medicinal treatments exist at this time. Surgery is needed in more than half
cases, while it is often leading to complications.
Minoxidil is a well-known antihypertensive drug used in adults and children. Furthermore,
according to animal studies, minoxidil seems to increase arterial elastin content by
decreasing elastase activity in these tissues. Other data demonstrate that minoxidil
specifically stimulate elastin synthesis.
Working Hypothesis: If insufficient elastin synthesis leads to vascular complications and
arterial hypertension in children with WBS, restoration of sufficient quantity of elastin
should then result in prevention or inhibition of vascular malformations and improvement in
arterial tension. Therefore, as a pharmacological agent capable to stimulate elastin
expression, minoxidil might be a useful drug for the treatment of abnormal elastin
metabolism in WBS children.
Objective: To evaluate the efficacy of minoxidil on cardiovascular structure in children with
Williams Beuren syndrome.
Methodology: randomized controlled trial on two parallel group (23 patients in each arm)
Main criterion: variation of carotid Intima-media thickness (IMT) before and after 12 months
of treatment with Minoxidil versus placebo Secondary intermediate criteria of the vascular
properties are arterial stiffness, cardiac and renal stenosis, arterial tension.
Total study duration: 30 months including a 12 month-recruitment period
Minoxidil 2% for Enhancement of Eyebrows [Not yet recruiting]
The purpose of the study is to compare minoxidil 2% versus placebo in enhancement of
Efficacy and Safety of Mesotherapy With Minoxidil 0.5%/2ml for Androgenetic Alopecia in Female Patients [Recruiting]
This study aims to investigate the effectiveness and safety of mesotherapy for the treatment
of female pattern alopecia.
- Sixty female subjects between 18 and 65 years diagnosed with female pattern hair loss
will undergo mesotherapy sessions weekly for ten weeks.
- One group will receive 0. 5%/2ml minoxidil application and a control group will receive
application of placebo (saline 0. 9%).
- Biopsy of the scalp, trichogram and trichoscopy (Fotofinder) will be performed before
and 08 weeks after treatment as a method objective evaluation of the response
A Study to Evaluate the Effectiveness and Safety of 5 Percent Minoxidil Foam in the Treatment of Male Pattern Hair Loss [Completed]
The primary purpose of the study is to evaluate the efficacy of a topical 5% minoxidil
formulation in males for the treatment of pattern hair loss. The secondary purpose is to
evaluate the safety of a topical 5% minoxidil formulation in males when used twice daily for
the treatment of pattern hair loss and to obtain the safety data on the investigational
product when used twice daily for up to one year.
Reports of Suspected Minoxidil Side Effects
Wrong Drug Administered (23),
Toxicity TO Various Agents (12),
Hypertension (11), more >>