DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Minocycline (Minocycline Hydrochloride) - Summary

 
 



MINOCYCLINE SUMMARY

Teratogenic Effects

Minocycline hydrochloride, a semisynthetic derivative of tetracyline, is 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy -1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.

Minocycline hydrochloride tablets are indicated in the treatment of the following infections due to susceptible strains of the designated microorganisms:

Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by Rickettsiae.

Respiratory tract infections caused by Mycoplasma pneumoniae.

Lymphogranuloma venereum caused by Chlamydia trachomatis.

Psittacosis (Ornithosis) due to Chlamydia psittaci.

Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunoflourescence.

Inclusion conjunctivitis caused by Chlamydia trachomatis.

Nongonococcal urethritis, endocervical, or rectal infections in adults caused by Ureaplasma urealyticum or Chlamydia trachomatis.

Relapsing fever due to Borrelia recurrentis.

Chancroid caused by Haemophilus ducreyi.

Plague due to Yersinia pestis.

Tularemia due to Francisella tularensis.

Cholera caused by Vibrio cholerae.

Campylobacter fetus infections caused by Campylobacter fetus.

Brucellosis due to Brucella species (in conjunction with streptomycin).

Bartonellosis due to Bartonella bacilliforms.

Granuloma inguinale caused by Calymmatobacterium granulomatis.

Minocycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug:

Escherichia coli.

Enterobacter aerogenes.

Shigella species.

Acinetobacter species.

Respiratory tract infections caused by Haemophilus influenzae.

Respiratory tract and urinary tract infections caused by Klebsiella species.

Minocycline hydrochloride tablets are indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:

Upper respiratory tract infections caused by Streptococcus pneumoniae.

Skin and skin structure infections caused by Staphylococcus aureus.

(Note: Minocycline is not the drug of choice in the treatment of any type of staphylococcal infection.)

Minocycline is an alternative drug in the treatment of the following gonococcal infections:

Uncomplicated urethritis in men due to Neisseria gonorrhoeae and for the treatment of other gonococcal infections when penicillin is contraindicated.

Infections in women caused by N eisseria gonorrhoeae.

Syphilis caused by Treponema pallidum subspecies pallidum.

Yaws caused by Treponema pallidum subspecies pertenue.

Listeriosis due to Listeria monocytogenes.

Anthrax due to Bacillus anthracis.

Vincent's infection caused by Fusobacterium fusiforme.

Actinomycosis caused by Actinomyces israelii.

Infections caused by Clostridium species.

In acute intestinal amebiasis, minocycline may be useful adjunct to amebicides.

In severe acne, minocycline may be useful adjunctive therapy.

Oral minocycline is indicated in the treatment of asymptomatic carriers of Neisseria meningitidis to eliminate the meningococci from the nasopharynx. In order to preserve the usefulness of minocycline in the treatment of asymptomatic meningococcal carrier, diagnostic laboratory procedures, including serotyping and susceptibility testing, should be performed to establish the carrier state and the correct treatment. It is recommended that the prophylactic use of minocycline be reserved for situations in which the risk of meningococcal meningitis is high.

Oral minocycline is not indicated for the treatment of meningococcal infection.

Although no controlled clinical efficacy studies have been conducted, limited clinical data show that oral minocycline hydrochloride has been used successfully in the treatment of infections caused by Mycobacterium marinum.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of the antibacterial drug product and other antibacterial drugs, the drug product should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antimicrobial therapy. In the absence of such data, local and susceptibility patterns may contribute to the empiric selection of therapy.


See all Minocycline indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Minocycline

Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment. [2012]
The onset and early course of schizophrenia is associated with subtle loss of grey matter which may be responsible for the evolution and persistence of symptoms such as apathy, emotional blunting, and social withdrawal...

Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury. [2012]
Preclinical studies have attributed neuroprotective properties to the antibiotic minocycline... Although this study does not establish the efficacy of minocycline in spinal cord injury the findings are encouraging and warrant further investigation in a multi-centre phase III trial.

Minocycline-EDTA lock solution prevents catheter-related bacteremia in hemodialysis. [2011.10]
There is growing concern about the development of antibacterial resistance with the use of antibiotics in catheter lock solutions...

Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. [2011.09.20]
OBJECTIVE: We conducted a study of minocycline to assess its safety, tolerability, and efficacy for the treatment of HIV-associated cognitive impairment... CONCLUSION: Minocycline was safe and well-tolerated in individuals with HIV-associated cognitive impairment, but cognitive improvement was not observed. Classification of evidence. This interventional study provides Class II evidence for the safety, tolerability, and efficacy of minocycline for the treatment of HIV-associated cognitive impairment.

Clinical and biochemical efficacy of minocycline in nonsurgical periodontal therapy: a randomized controlled pilot study. [2011.06]
The present study evaluated the effects of systemic minocycline on clinical and biochemical parameters of chronic periodontitis, which is a common inflammatory disorder of the periodontium initiated by the presence of bacteria in the gingival sulcus...

more studies >>

Clinical Trials Related to Minocycline

Pilot Study of Minocycline in Huntington's Disease [Active, not recruiting]
This study is being conducted to assess the impact of minocycline on the progression of symptoms of HD. The study will also assess whether it is reasonable to continue with further study of minocycline in HD. We will measure the effect of minocycline on HD by measuring the change in Huntington's disease symptoms.

Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone [Completed]
The purpose of this study is to determine if a combination of methotrexate and minocycline works better than methotrexate alone in early Rheumatoid Arthritis

Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris [Completed]

Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke [Recruiting]
The primary aim of this study is to find out which of 4 different doses of minocycline are safe and well tolerated so that we will know the optimal dose to test in future patients.

Trial of Minocycline to Treat Children With Fragile X Syndrome [Recruiting]
This is a single center study at the UC Davis MIND Institute in patients age 3. 5-16 years of age with fragile X syndrome (FXS), funded by a National Fragile X Foundation Grant. It is a controlled trial of minocycline, an antibiotic commonly used in children for infection or for treatment of neurodegenerative disorders. We are investigating its use in FXS because it lowers matrix metalloproteinase 9 (MMP9) levels, which are high in FXS, and it also strengthens brain connections in the animal models of FXS. We hypothesize that minocycline will likely be helpful for language, behavior and/or cognition in fragile X patients.

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 20 ratings/reviews, Minocycline has an overall score of 5.85. The effectiveness score is 6.70 and the side effect score is 7.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Minocycline review by 25 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   5mg taken 2 times/day for the period of 6 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   face cleared up conciderably. It took about 2 months for the drug to become conciderably effective though.
Side effects:   There were no side effects associated with the drug. The doctor mentioned it would make birth control ineffective but had no confirmation of that.
Comments:   Face and body cleared up conciderably. It did take a while for the drug to take effect - but was worth it in the end. I am now pregnant and will continue treatments after I have the baby. Once I stopped taking it before I got pregnant - my face began to break out again. So you really have to continue to take it to keep the benefits.

 

Minocycline review by 35 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Treatment of acne
Dosage & duration:   75mg taken once a day for the period of 1 year
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I took Minocycline hoping that it would clear up my acne. I have been taking Tetracycline for over 2 years without no result, frustrated, my doctor prescribed Minocyline. After 1 year, I was still having break out just not as bad.
Side effects:   The treatment had no side effect on me.
Comments:   I don't have severe acne problem, just occasional break out. I was prescribed Minocycline by my doctor and was advised to take it once a day for treatment of my acne. I was told that it would take up to six month to see result. After more than a year being on it, it did very little for me. I was still breaking out, it just that some of my break out was not as bad. Bottom line, I was not satisfied because it did not help clear up my acne altogether.

 

Minocycline review by 22 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   100mg taken twice a day for the period of 5 days
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Decreased the number of acne lesions.
Side effects:   Major Headaches Neck Pain
Comments:   I have been taking minocycline 100mg twice a day. At first I had no side effects what so ever. However after a week I started heaving headaches and they gradually got worse. It was when I started having neck pains, I stopped using Minocycline. Although I stopped using it, I never thought the pains were due to it - I thought it was from going out right after the shower which I often do. That same night I woke up with hives appearing in my body and towards the end of the day, my face got swollen (eyes and my inner lip.) At first I thought it was a food allergy, went to the doctor and got a full blood test (White blood cells, red cells, cholesterol, sugar, full allergy, almost everything.) During the waiting period of my results (took about a week and a half) I was taking steroid pills for allergies and I got back to normal within 5 days. On the 8th day, I was like hmm lets take minocycline again, I wanna be proactive and not break out on acne again. I took one pill at night after 8 days of not using it, and the next day I got itchy hands and a few hives and then I realized it was the minocycline that I was reacting to. Luckily I only took one pill and over the counter allergy medicine such as zyrtec got rid off my itchiness and I am back to normal again. So around 8-9 days later after I gave blood, the results came to my doctor. To my surprise everything came normal no allergies what so ever, no pollen, no nuts, no nuts, no dust completely NO ALLERGIES. My Red Blood cell count along with hematocrit came a little high but nothing else. I am almost confident to say that minocycline was what I was reacting to and my doctor told me to stop taking it.

See all Minocycline reviews / ratings >>

Page last updated: 2013-02-10

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2014