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Minocycline (Minocycline Hydrochloride) - Summary

 
 



MINOCYCLINE SUMMARY

Minocycline hydrochloride is an antibiotic, a semisynthetic derivative of tetracycline.

Minocycline hydrochloride capsules are indicated in the treatment of the following infections due to susceptible strains of the designated microorganisms:
     Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by Rickettsiae.
     Respiratory tract infections caused by Mycoplasma pneumoniae.
     Lymphogranuloma venereum caused by Chlamydia trachomatis.
     Psittacosis (Ornithosis) due to Chlamydia psittaci.
     Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunofluorescence.
     Inclusion conjunctivitis caused by Chlamydia trachomatis.
     Nongonococcal urethritis, endocervical, or rectal infections in adults caused by Ureaplasma urealyticum or Chlamydia trachomatis.
     Relapsing fever due to Borrelia recurrentis.
     Chancroid caused by Haemophilus ducreyi.
     Plague due to Yersinia pestis.
     Tularemia due to Francisella tularensis.
     Cholera caused by Vibrio cholerae.
     Campylobacter fetus infections caused by Campylobacter fetus.
     Brucellosis due to Brucella species (in conjunction with streptomycin).
     Bartonellosis due to Bartonella bacilliformis.
     Granuloma inguinale caused by Calymmatobacterium granulomatis.
Minocycline is indicated for the treatment of infections caused by the following gram-negative microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
     Escherichia coli.
     Enterobacter aerogenes.
     Shigella species.
     Acinetobacter species.
     Respiratory tract infections caused by Haemophilus influenzae.
     Respiratory tract and urinary tract infections caused by Klebsiella species.
Minocycline hydrochloride capsules are indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
     Upper respiratory tract infections caused by Streptococcus pneumoniae.
     Skin and skin structure infections caused by Staphylococcus aureus. (Note: Minocycline is not the drug of choice in the treatment of any type of staphylococcal infection.)
When penicillin is contraindicated, minocycline is an alternative drug in the treatment of the following infections:
     Uncomplicated urethritis in men due to Neisseria gonorrhoeae and for the treatment of other gonococcal infections.
     Infections in women caused by Neisseria gonorrhoeae.
     Syphilis caused by Treponema pallidum subspecies pallidum.
     Yaws caused by Treponema pallidum subspecies pertenue.
     Listeriosis due to Listeria monocytogenes.
     Anthrax due to Bacillus anthracis.
     Vincent's infection caused by Fusobacterium fusiforme.
     Actinomycosis caused by Actinomyces israelii.
     Infections caused by Clostridium species.
In acute intestinal amebiasis, minocycline may be a useful adjunct to amebicides.
In severe acne, minocycline may be useful adjunctive therapy.
Oral minocycline is indicated in the treatment of asymptomatic carriers of Neisseria meningitidis to eliminate meningococci from the nasopharynx. In order to preserve the usefulness of minocycline in the treatment of asymptomatic meningococcal carriers, diagnostic laboratory procedures, including serotyping and susceptibility testing, should be performed to establish the carrier state and the correct treatment. It is recommended that the prophylactic use of minocycline be reserved for situations in which the risk of meningococcal meningitis is high.
Oral minocycline is not indicated for the treatment of meningococcal infection.
Although no controlled clinical efficacy studies have been conducted, limited clinical data show that oral minocycline hydrochloride has been used successfully in the treatment of infections caused by Mycobacterium marinum.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of minocycline hydrochloride capsules and other antibacterial drugs, minocycline hydrochloride capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.


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NEWS HIGHLIGHTS

Published Studies Related to Minocycline

Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator. [2015]
the treatment of neuropathic pain... CONCLUSIONS: Although both groups differed from placebo, their effect size was

Effect of Minocycline on Lumbar Radicular Neuropathic Pain: A Randomized, Placebo-controlled, Double-blind Clinical Trial with Amitriptyline as a Comparator. [2014]
the treatment of neuropathic pain... CONCLUSIONS:: Although both groups differed from placebo, their effect size was

Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. [2014]
Elevated cerebrospinal fluid (CSF) levels of markers of oxidative stress, neuronal injury, and inflammation and decreased neurotransmitter levels have been reported in HIV-associated neurocognitive disorders (HAND). Minocycline may have a neuroprotective effect by inhibiting inducible nitric oxide synthase, which produces nitric oxide, a compound that induces oxygen free radical production...

Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial. [2014]
patients with schizophrenia... CONCLUSIONS: The addition of minocycline to atypical antipsychotic drugs in early

Adjuvant therapy with minocycline for schizophrenia (The MINOS Trial): study protocol for a double-blind randomized placebo-controlled trial. [2013]
BACKGROUND: Schizophrenia is understood to be a heterogeneous brain condition with overlapping symptom dimensions. The negative symptom dimension, with its protean cognitive manifestations, responds poorly to treatment, which can be a particular challenge in countries where clozapine therapy is not available.

more studies >>

Clinical Trials Related to Minocycline

Study to Evaluate the Efficacy and Safety of Minocycline in Angelman Syndrome [Active, not recruiting]

Minocycline and Aspirin in the Treatment of Bipolar Depression [Recruiting]
The purpose of this study is to determine whether Minocycline and aspirin are effective in the treatment of depression in Bipolar patients.

Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy [Active, not recruiting]
The goal of this clinical research study is to learn if minocycline can reduce the side effects reported by patients with NSCLC who are receiving chemoradiation therapy. In this study, minocycline will be compared to a placebo. Minocycline is an antibiotic that may help to reduce side effects of chemoradiation therapy. A placebo is not a drug. It looks like the study drug but is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer [Recruiting]
The goal of this clinical research study is to learn if Minocin (minocycline) can reduce certain side effects of surgery in patients with head and neck cancer (such as pain, fatigue, and disturbed sleep). In this study, minocycline will be compared to a placebo. A placebo is not a drug. It looks like the study drug, but it is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

Minocycline Therapy for Management of Adverse Radiation Effects [Not yet recruiting]
Stereotactic radiosurgery (SRS) is a well-established treatment for patients with metastatic brain tumors. Although SRS has a very high tumor growth control these interventions are associated with adverse radiation effects (ARE) in approximately 15 % of patients. The traditional approach, and still a mainstay, is the administration of a course of high dose anti-inflammatory corticosteroids. Currently there are no other effective oral neuroprotective agents in clinical practice which can improve outcomes of patients with ARE after radiosurgery for brain metastases. Minocycline, an antibiotic with a favorable adverse effect profile and pharmacokinetics, has been shown to have neuroprotective properties in experimental models of a variety of neurological diseases, as well as in human clinical trials. The investigators propose a single arm clinical trial, to evaluate the safety and feasibility of minocycline in improving ARE. This study will recruit 15 patients who will be treated with minocycline (100mg BID) for 3 months. This clinical trial has the potential to prove that minocycline therapy is safe in this patient population. In addition, positive results will provide preliminary evidence for its use in an array of radiosurgical indications.

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 20 ratings/reviews, Minocycline has an overall score of 5.85. The effectiveness score is 6.70 and the side effect score is 7.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Minocycline review by 25 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   5mg taken 2 times/day for the period of 6 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   face cleared up conciderably. It took about 2 months for the drug to become conciderably effective though.
Side effects:   There were no side effects associated with the drug. The doctor mentioned it would make birth control ineffective but had no confirmation of that.
Comments:   Face and body cleared up conciderably. It did take a while for the drug to take effect - but was worth it in the end. I am now pregnant and will continue treatments after I have the baby. Once I stopped taking it before I got pregnant - my face began to break out again. So you really have to continue to take it to keep the benefits.

 

Minocycline review by 35 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Treatment of acne
Dosage & duration:   75mg taken once a day for the period of 1 year
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I took Minocycline hoping that it would clear up my acne. I have been taking Tetracycline for over 2 years without no result, frustrated, my doctor prescribed Minocyline. After 1 year, I was still having break out just not as bad.
Side effects:   The treatment had no side effect on me.
Comments:   I don't have severe acne problem, just occasional break out. I was prescribed Minocycline by my doctor and was advised to take it once a day for treatment of my acne. I was told that it would take up to six month to see result. After more than a year being on it, it did very little for me. I was still breaking out, it just that some of my break out was not as bad. Bottom line, I was not satisfied because it did not help clear up my acne altogether.

 

Minocycline review by 22 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   100mg taken twice a day for the period of 5 days
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Decreased the number of acne lesions.
Side effects:   Major Headaches Neck Pain
Comments:   I have been taking minocycline 100mg twice a day. At first I had no side effects what so ever. However after a week I started heaving headaches and they gradually got worse. It was when I started having neck pains, I stopped using Minocycline. Although I stopped using it, I never thought the pains were due to it - I thought it was from going out right after the shower which I often do. That same night I woke up with hives appearing in my body and towards the end of the day, my face got swollen (eyes and my inner lip.) At first I thought it was a food allergy, went to the doctor and got a full blood test (White blood cells, red cells, cholesterol, sugar, full allergy, almost everything.) During the waiting period of my results (took about a week and a half) I was taking steroid pills for allergies and I got back to normal within 5 days. On the 8th day, I was like hmm lets take minocycline again, I wanna be proactive and not break out on acne again. I took one pill at night after 8 days of not using it, and the next day I got itchy hands and a few hives and then I realized it was the minocycline that I was reacting to. Luckily I only took one pill and over the counter allergy medicine such as zyrtec got rid off my itchiness and I am back to normal again. So around 8-9 days later after I gave blood, the results came to my doctor. To my surprise everything came normal no allergies what so ever, no pollen, no nuts, no nuts, no dust completely NO ALLERGIES. My Red Blood cell count along with hematocrit came a little high but nothing else. I am almost confident to say that minocycline was what I was reacting to and my doctor told me to stop taking it.

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Page last updated: 2015-08-10

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