MINOCYCLINE SUMMARY
Teratogenic Effects
Minocycline hydrochloride, a semisynthetic derivative of tetracyline, is 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy
-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.
Minocycline hydrochloride tablets are indicated in the treatment of the following infections due to susceptible strains of the designated microorganisms:
Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by
Rickettsiae.
Respiratory tract infections caused by
Mycoplasma pneumoniae.
Lymphogranuloma venereum caused by
Chlamydia trachomatis.
Psittacosis (Ornithosis) due to
Chlamydia psittaci.
Trachoma caused by
Chlamydia trachomatis,
although the infectious agent is not always eliminated, as judged by immunoflourescence.
Inclusion conjunctivitis caused by
Chlamydia trachomatis.
Nongonococcal urethritis, endocervical, or rectal infections in adults caused by
Ureaplasma urealyticum
or
Chlamydia trachomatis.
Relapsing fever due to
Borrelia recurrentis.
Chancroid caused by
Haemophilus ducreyi.
Plague due to
Yersinia pestis.
Tularemia due to
Francisella tularensis.
Cholera caused by
Vibrio cholerae.
Campylobacter fetus infections caused by
Campylobacter fetus.
Brucellosis due to
Brucella
species (in conjunction with streptomycin).
Bartonellosis due to
Bartonella bacilliforms.
Granuloma inguinale caused by
Calymmatobacterium granulomatis.
Minocycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug:
Escherichia coli.
Enterobacter aerogenes.
Shigella
species.
Acinetobacter
species.
Respiratory tract infections caused by
Haemophilus influenzae.
Respiratory tract and urinary tract infections caused by
Klebsiella
species.
Minocycline hydrochloride tablets are indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
Upper respiratory tract infections caused by
Streptococcus pneumoniae.
Skin and skin structure infections caused by
Staphylococcus aureus.
(Note: Minocycline is not the drug of choice in the treatment of any type of staphylococcal infection.)
Minocycline is an alternative drug in the treatment of the following gonococcal infections:
Uncomplicated urethritis in men due to
Neisseria gonorrhoeae
and for the treatment of other gonococcal infections when penicillin is contraindicated.
Infections in women caused by N
eisseria gonorrhoeae.
Syphilis caused by
Treponema pallidum
subspecies
pallidum.
Yaws caused by
Treponema pallidum
subspecies
pertenue.
Listeriosis due to
Listeria monocytogenes.
Anthrax due to
Bacillus anthracis.
Vincent's infection caused by
Fusobacterium fusiforme.
Actinomycosis caused by
Actinomyces israelii.
Infections caused by
Clostridium
species.
In
acute intestinal amebiasis,
minocycline may be useful adjunct to amebicides.
In severe acne, minocycline may be useful adjunctive therapy.
Oral minocycline is indicated in the treatment of asymptomatic carriers of
Neisseria meningitidis
to eliminate the meningococci from the nasopharynx. In order to preserve the usefulness of minocycline in the treatment of asymptomatic meningococcal carrier, diagnostic laboratory procedures, including serotyping and susceptibility testing, should be performed to establish the carrier state and the correct treatment. It is recommended that the prophylactic use of minocycline be reserved for situations in which the risk of meningococcal meningitis is high.
Oral minocycline is not indicated for the treatment of meningococcal infection.
Although no controlled clinical efficacy studies have been conducted, limited clinical data show that oral minocycline hydrochloride has been used successfully in the treatment of infections caused by
Mycobacterium marinum.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of the antibacterial drug product and other antibacterial drugs, the drug product should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antimicrobial therapy. In the absence of such data, local and susceptibility patterns may contribute to the empiric selection of therapy.
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