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Minocin (Minocycline Hydrochloride) - Summary

 
 



MINOCIN SUMMARY

MINOCIN® minocycline hydrochloride, is an antibacterial drug, a semisynthetic derivative of tetracycline.

MINOCIN® Pellet-Filled Capsules are indicated in the treatment of the following infections due to susceptible strains of the designated microorganisms:

  Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by rickettsiae.

  Respiratory tract infections caused by Mycoplasma pneumoniae.

  Lymphogranuloma venereum caused by Chlamydia trachomatis.

  Psittacosis (Ornithosis) due to Chlamydia psittaci.

  Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunofluorescence.

  Inclusion conjunctivitis caused by Chlamydia trachomatis.

  Nongonococcal urethritis, endocervical, or rectal infections in adults caused by Ureaplasma urealyticum or Chlamydia trachomatis.

  Relapsing fever due to Borrelia recurrentis.

  Chancroid caused by Haemophilus ducreyi.

  Plague due to Yersinia pestis.

  Tularemia due to Francisella tularensis.

  Cholera caused by Vibrio cholerae.

  Campylobacter fetus infections caused by Campylobacter fetus.

  Brucellosis due to Brucella species (in conjunction with streptomycin).

  Bartonellosis due to Bartonella bacilliformis.

  Granuloma inguinale caused by Calymmatobacterium granulomatis.

Minocycline is indicated for the treatment of infections caused by the following gram-negative microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:

  Escherichia coli.

  Enterobacter aerogenes.

  Shigella species.

  Acinetobacter species.

  Respiratory tract infections caused by Haemophilus influenzae.

  Respiratory tract and urinary tract infections caused by Klebsiella species.

MINOCIN® Pellet-Filled Capsules are indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:

  Upper respiratory tract infections caused by Streptococcus pneumoniae.

  Skin and skin structure infections caused by Staphylococcus aureus. (Note: Minocycline is not the drug of choice in the treatment of any type of staphylococcal infection.)

When penicillin is contraindicated, minocycline is an alternative drug in the treatment of the following infections:

  Uncomplicated urethritis in men due to Neisseria gonorrhoeae and for the treatment of other gonococcal infections.

  Infections in women caused by Neisseria gonorrhoeae.

  Syphilis caused by Treponema pallidum subspecies pallidum.

  Yaws caused by Treponema pallidum subspecies pertenue.

  Listeriosis due to Listeria monocytogenes.

  Anthrax due to Bacillus anthracis.

  Vincent’s infection caused by Fusobacterium fusiforme.

  Actinomycosis caused by Actinomyces   israelii.

  Infections caused by Clostridium species.

In acute intestinal amebiasis, minocycline may be a useful adjunct to amebicides.

In severe acne, minocycline may be useful adjunctive therapy.

Oral minocycline is indicated in the treatment of asymptomatic carriers of Neisseria   meningitidis to eliminate meningococci from the nasopharynx. In order to preserve the usefulness of minocycline in the treatment of asymptomatic meningococcal carriers, diagnostic laboratory procedures, including serotyping and susceptibility testing, should be performed to establish the carrier state and the correct treatment. It is recommended that the prophylactic use of minocycline be reserved for situations in which the risk of meningococcal meningitis is high.

Oral minocycline is not indicated for the treatment of meningococcal infection.

Although no controlled clinical efficacy studies have been conducted, limited clinical data show that oral minocycline hydrochloride has been used successfully in the treatment of infections caused by Mycobacterium marinum.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of MINOCIN® (minocycline hydrochloride) Pellet-Filled Capsules and other antibacterial drugs, MINOCIN® (minocycline hydrochloride) Pellet-Filled Capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.


See all Minocin indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Minocin (Minocycline)

Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator. [2015]
the treatment of neuropathic pain... CONCLUSIONS: Although both groups differed from placebo, their effect size was

Effect of Minocycline on Lumbar Radicular Neuropathic Pain: A Randomized, Placebo-controlled, Double-blind Clinical Trial with Amitriptyline as a Comparator. [2014]
the treatment of neuropathic pain... CONCLUSIONS:: Although both groups differed from placebo, their effect size was

Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. [2014]
Elevated cerebrospinal fluid (CSF) levels of markers of oxidative stress, neuronal injury, and inflammation and decreased neurotransmitter levels have been reported in HIV-associated neurocognitive disorders (HAND). Minocycline may have a neuroprotective effect by inhibiting inducible nitric oxide synthase, which produces nitric oxide, a compound that induces oxygen free radical production...

Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial. [2014]
patients with schizophrenia... CONCLUSIONS: The addition of minocycline to atypical antipsychotic drugs in early

Adjuvant therapy with minocycline for schizophrenia (The MINOS Trial): study protocol for a double-blind randomized placebo-controlled trial. [2013]
BACKGROUND: Schizophrenia is understood to be a heterogeneous brain condition with overlapping symptom dimensions. The negative symptom dimension, with its protean cognitive manifestations, responds poorly to treatment, which can be a particular challenge in countries where clozapine therapy is not available.

more studies >>

Clinical Trials Related to Minocin (Minocycline)

Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer [Recruiting]
The goal of this clinical research study is to learn if Minocin (minocycline) can reduce certain side effects of surgery in patients with head and neck cancer (such as pain, fatigue, and disturbed sleep). In this study, minocycline will be compared to a placebo. A placebo is not a drug. It looks like the study drug, but it is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy [Active, not recruiting]
The goal of this clinical research study is to learn if minocycline can reduce the side effects reported by patients with NSCLC who are receiving chemoradiation therapy. In this study, minocycline will be compared to a placebo. Minocycline is an antibiotic that may help to reduce side effects of chemoradiation therapy. A placebo is not a drug. It looks like the study drug but is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer [Active, not recruiting]
The goal of this clinical research study is to compare armodafinil and minocycline when given alone or in combination to learn which is better for controlling side effects of chemoradiation treatment for esophageal cancer (such as fatigue, pain, disturbed sleep, lack of appetite, and drowsiness). Armodafinil is designed to prevent excessive sleepiness. Minocycline is an antibiotic, which may help to reduce multiple symptoms. In this study, you may receive a placebo. A placebo is not a drug. It looks like the study drug but is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil [Active, not recruiting]
The goal of this clinical research study is to compare armodafinil and minocycline when given alone or in combination to learn which is better for controlling symptoms, such as the side effects of chemoradiation, when given to treat lung cancer.

Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients [Recruiting]
The goal of this clinical research study is to learn if minocycline can reduce numbness, pain, and/or loss of motor function in patients with colorectal cancer. In this study, minocycline will be compared to a placebo. The study doctor can explain how the study drug is designed to work. A placebo is not a drug. It looks like the study drug, but it is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

more trials >>

Reports of Suspected Minocin (Minocycline) Side Effects

Alanine Aminotransferase Increased (8)Aspartate Aminotransferase Increased (8)Jaundice (7)Liver Injury (7)Hyperbilirubinaemia (7)Gamma-Glutamyltransferase Increased (7)Blood Alkaline Phosphatase Increased (7)Vomiting (7)Diarrhoea (7)Drug Hypersensitivity (4)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Minocin has an overall score of 6.67. The effectiveness score is 8 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Minocin review by 26 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Cystic Acne
Dosage & duration:   50 MG taken twice a day for the period of About 4 years
Other conditions:   None
Other drugs taken:   just vitamin supplements
  
Reported Results
Benefits:   My cystic acne was reduced. My face did clear up consistently with the help of the pills and creams such as retin-a.
Side effects:   I needed to take the pills with lots of water, so I was always taking trips to the bathroom. I was on this pill for a long time, and I dont know if the constant ringing of my ears was a side effect, I did visit an ear doctor for this problem I thought was tinnitus but the doctor assured me the minocin had nothing to do with it. The ringing of the ears continued for about a year after I stopped taking minocycline. Occasionally I still get a ringing of the years, it can be sudden but lasts for a second or so...I was never diagnosed with tinnutus, but the ringing did lessen until it left after i stopped the pills.
Comments:   I was to take the pills twice a day with water. I took one in the morning after I ate, and one at night with plenty of water....after a year my body became resistant to the pill and stopped working, and i started taking higher doses without my doctors consent..which was wrong of me and dangerous and maybe that is why the ringing of my ears began...but I was obssessed with clearing up my acne. I was young, I believe i was 17 or eighteen when i started minocin and was on and off it for about 4 years.

 

Minocin review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Acne
Dosage & duration:   100 MG taken 1 x per day for the period of 1 year
Other conditions:   None
Other drugs taken:   none
  
Reported Results
Benefits:   It reduced the severity of acne eruptions.
Side effects:   Upset stomach; yeast infections
Comments:   I first starting taking it for frequent adult acne. The medication did work, and I quit taking it. But the acne returned so I went back on the Minocin. After 3 months on, I had frequent vaginal yeast infections, but no acne. I have been taking it for a year, and it no longer clears up the acne eruptions.

 

Minocin review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Acne
Dosage & duration:   100 MG taken 1 x per day for the period of 1 year
Other conditions:   None
Other drugs taken:   none
  
Reported Results
Benefits:   It reduced the severity of acne eruptions.
Side effects:   Upset stomach; yeast infections
Comments:   I first starting taking it for frequent adult acne. The medication did work, and I quit taking it. But the acne returned so I went back on the Minocin. After 3 months on, I had frequent vaginal yeast infections, but no acne. I have been taking it for a year, and it no longer clears up the acne eruptions.

See all Minocin reviews / ratings >>

Page last updated: 2015-08-10

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