NEWS HIGHLIGHTS
Published Studies Related to Minitran (Nitroglycerin Transdermal)
Transdermal nitroglycerin therapy may not prevent early postmenopausal bone loss. [2009.09]
CONTEXT: Osteoporosis is common among postmenopausal women; animal studies and human pilot studies support the concept of nitric oxide (NO) donors reducing bone mineral density loss. OBJECTIVE: The objective of the study was to evaluate whether NO donor, nitroglycerin, prevents postmenopausal bone loss... CONCLUSIONS: BMD changes did not substantially differ between postmenopausal women who received the dose of nitroglycerin tested, in comparison with a placebo. Once-daily dosing with 22.5 mg of transdermal-administered nitroglycerin was not effective (compliance adjusted dose was only approximately 16 mg/d); a sub-therapeutic dose.
Transdermal nitroglycerin as an adjuvant to patient-controlled morphine analgesia after total knee arthroplasty. [2009.03]
BACKGROUND: Nitroglycerin (NTG) has been shown to be a useful adjunct for pain treatment without increasing adverse side effects. The effects of NTG on postoperative morphine consumption after knee replacement were evaluated... CONCLUSIONS: The use of NTG patches conferred no advantage over the use of placebo in patients receiving patient-controlled morphine analgesia after total knee replacement. Two myocardial infarcts occurred in this group. Therefore, the safety of postoperative NTG patch use for pain control must be questioned.
Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. [2007.09]
CONCLUSIONS: We show important differences among organic nitrates in their capacity to prevent IR-induced endothelial dysfunction. GTN and PETN, but not ISMN, have this preconditioning effect. The potential clinical implications of these data warrant further investigation.
Pentaerythrityl Tetranitrate and Nitroglycerin, but not Isosorbide Mononitrate, Prevent Endothelial Dysfunction Induced by Ischemia and Reperfusion. [2007.07.19]
CONCLUSIONS: We show important differences among organic nitrates in their capacity to prevent IR-induced endothelial dysfunction. GTN and PETN, but not ISMN, have this preconditioning effect. The potential clinical implications of these data warrant further investigation.
Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor. [2007.01]
OBJECTIVE: Despite advances in perinatal medicine, the incidence of preterm birth continues to increase. The primary goal of tocolytic therapy is to reduce neonatal morbidity and mortality. While studies have demonstrated a prolongation of pregnancy, no tocolytic has been shown to improve neonatal outcomes. The objective of this randomized placebo-controlled trial was to determine the effect of transdermal nitroglycerin on neonatal outcomes in women who present in preterm labor... CONCLUSION: Transdermal nitroglycerin may reduce neonatal morbidity and mortality as a result of decreased risk of birth before 28 weeks.
Clinical Trials Related to Minitran (Nitroglycerin Transdermal)
MQX-503 vs Nitroglycerin Ointment: A Pharmacokinetic Comparison in Normal Subjects [Completed]
The purpose of the study is to measure how much nitroglycerin or its metabolites may be found
in the bloodstream when MQX-503 or an FDA approved Nitroglycerin ointment 2% USP is applied
to the skin of healthy subjects.
Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina [Completed]
The purpose of the study is to determine for how long sildenafil potentiates the blood
pressure reduction that occurs with glyceryl trinitrate in men with angina.
A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon [Active, not recruiting]
The purpose of this research study is to test the safety, tolerability, and effectiveness of
Topical AmphiMatrix with Nitroglycerin (MQX0503) to relieve Raynaud's symptoms and increase
blood flow to the fingers.
Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter [Recruiting]
The radial artery, which is located on the outer side of the forearm, can be used in
interventional procedures, such as cardiac catheterization, to provide access to the arterial
blood supply. In order to facilitate successful catheterization of the artery, a dilated
artery and one free of arterial spasm is desirable. The proposed study will randomize twenty
three healthy subjects to determine the effect of topical nitroglycerin on radial artery
vasodilation. In the first phase of the study, which is a dose escalation study, each subject
will receive either one or two inches of nitroglycerin in a blinded manner on one wrist and
placebo on the other. Radial artery diameter will be measured with ultrasound at regular
intervals up to two hours. The subjects will then return at a later date at which point they
will receive the alternate dose on one wrist and placebo on the other. In the second phase of
the study, we will randomize the same patients to a mixture of topical nitroglycerin and
lidocaine or topical lidocaine alone. Measurements of radial artery diameter will be
performed as in the first study.
Dose Response to Topical Glyceryl Trinitrate in Patients With Raynaud's Phenomenon [Recruiting]
The purpose of this study is to evaluate the blood flow response to topical Glyceryl
Trinitrate when applied to the skin of patient's fingers with Raynaud's Phenomenon.
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