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Minipress (Prazosin Hydrochloride) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Clinical trials were conducted on more than 900 patients. During these trials and subsequent marketing experience, the most frequent reactions associated with MINIPRESS therapy are: dizziness 10.3%, headache 7.8%, drowsiness 7.6%, lack of energy 6.9%, weakness 6.5%, palpitations 5.3%, and nausea 4.9%. In most instances side effects have disappeared with continued therapy or have been tolerated with no decrease in dose of drug.

Less frequent adverse reactions which are reported to occur in 1–4% of patients are:

Gastrointestinal: vomiting, diarrhea, constipation.

Cardiovascular: edema, orthostatic hypotension, dyspnea, syncope.

Central Nervous System: vertigo, depression, nervousness.

Dermatologic: rash.

Genitourinary: urinary frequency.

EENT: blurred vision, reddened sclera, epistaxis, dry mouth, nasal congestion.

In addition, fewer than 1% of patients have reported the following (in some instances, exact causal relationships have not been established):

Gastrointestinal: abdominal discomfort and/or pain, liver function abnormalities, pancreatitis.

Cardiovascular: tachycardia.

Central Nervous System: paresthesia, hallucinations.

Dermatologic: pruritus, alopecia, lichen planus.

Genitourinary: incontinence, impotence, priapism.

EENT: tinnitus.

Other: diaphoresis, fever, positive ANA titer, arthralgia.

Single reports of pigmentary mottling and serous retinopathy, and a few reports of cataract development or disappearance have been reported. In these instances, the exact causal relationship has not been established because the baseline observations were frequently inadequate.

In more specific slit-lamp and funduscopic studies, which included adequate baseline examinations, no drug-related abnormal ophthalmological findings have been reported.

Literature reports exist associating MINIPRESS therapy with a worsening of pre-existing narcolepsy. A causal relationship is uncertain in these cases.

In post-marketing experience, the following adverse events have been reported:

Autonomic Nervous System: flushing.

Body As A Whole: allergic reaction, asthenia, malaise, pain.

Cardiovascular, General: angina pectoris, hypotension.

Endocrine: gynecomastia.

Heart Rate/Rhythm: bradycardia.

Psychiatric: insomnia.

Skin/Appendages: urticaria.

Vascular (Extracardiac): vasculitis.

Vision: eye pain.



REPORTS OF SUSPECTED MINIPRESS SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Minipress. The information is not vetted and should not be considered as verified clinical evidence.

Possible Minipress side effects / adverse reactions in 97 year old female

Reported by a consumer/non-health professional from United States on 2012-02-10

Patient: 97 year old female

Reactions: Dizziness

Suspect drug(s):
Minipress
    Dosage: 4 mg, 2x/day
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-01-01

Prazosin Hydrochloride
    Dosage: 4 mg, 2x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2012-01-01



Possible Minipress side effects / adverse reactions in 50 year old male

Reported by a physician from Switzerland on 2012-03-27

Patient: 50 year old male

Reactions: Hearing Impaired

Suspect drug(s):
Minipress



Possible Minipress side effects / adverse reactions in 50 year old male

Reported by a physician from Switzerland on 2012-04-06

Patient: 50 year old male

Reactions: Hearing Impaired

Suspect drug(s):
Minipress

Other drugs received by patient: Trazodone HCL; Atorvastatin Calcium; Venlafaxine; Neurontin; Trazodone HCL; Aspirin; Venlafaxine; Calcimagon-D3; Lamictal; Voltaren



See index of all Minipress side effect reports >>

Drug label data at the top of this Page last updated: 2006-02-06

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