NEWS HIGHLIGHTS
Published Studies Related to Minipress (Prazosin)
A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. [2009.02]
BACKGROUND: Current medications for alcohol dependence (AD) show only modest efficacy. None target brain noradrenergic pathways. Theory and preclinical evidence suggest that noradrenergic circuits may be involved in alcohol reinforcement and relapse. We therefore tested the alpha-1 adrenergic receptor antagonist, prazosin, as a pharmacotherapy for AD... CONCLUSIONS: Prazosin holds promise as a pharmacologic treatment for AD and deserves further evaluation in a larger controlled trial.
A Pilot Trial of the Alpha-1 Adrenergic Antagonist, Prazosin, for Alcohol Dependence. [2008.10.21]
Background: Current medications for alcohol dependence (AD) show only modest efficacy. None target brain noradrenergic pathways.
Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study. [2008.03.15]
BACKGROUND: Prazosin, a central nervous system (CNS) active alpha-1 adrenoreceptor antagonist, has reduced nightmares and sleep disturbance in placebo-controlled studies of combat-related posttraumatic stress disorder (PTSD). We evaluated objective sleep parameters and PTSD symptoms in a placebo-controlled prazosin trial for civilian trauma-related PTSD... CONCLUSIONS: Prazosin reductions of nighttime PTSD symptoms in civilian trauma PTSD are accompanied by increased total sleep time, REM sleep time, and mean REM period duration in the absence of a sedative-like effect on sleep onset latency.
Prazosin Effects on Objective Sleep Measures and Clinical Symptoms in Civilian Trauma Posttraumatic Stress Disorder: A Placebo-Controlled Study. [2007.09.12]
BACKGROUND: Prazosin, a central nervous system (CNS) active alpha-1 adrenoreceptor antagonist, has reduced nightmares and sleep disturbance in placebo-controlled studies of combat-related posttraumatic stress disorder (PTSD). We evaluated objective sleep parameters and PTSD symptoms in a placebo-controlled prazosin trial for civilian trauma-related PTSD... CONCLUSIONS: Prazosin reductions of nighttime PTSD symptoms in civilian trauma PTSD are accompanied by increased total sleep time, REM sleep time, and mean REM period duration in the absence of a sedative-like effect on sleep onset latency.
A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. [2007.04.15]
BACKGROUND: Excessive brain responsiveness to norepinephrine appears to contribute to post-traumatic stress disorder (PTSD), particularly at night. Prazosin, a brain active alpha-1 adrenergic receptor antagonist, significantly reduced trauma nightmares and sleep disturbance in 10 Vietnam War combat veterans in a previous placebo-controlled crossover study. The current parallel group trial in a larger sample of veterans evaluated prazosin effects on trauma nightmares, sleep quality, global clinical status, dream characteristics, and comorbid depression... CONCLUSIONS: Prazosin is an effective and well-tolerated treatment for trauma nightmares, sleep disturbance and global clinical status in veterans with chronic PTSD.
Clinical Trials Related to Minipress (Prazosin)
Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) [Recruiting]
The purpose of this study is to determine whether prazosin will:
- reduce the incidence of nightmares and sleep disturbance
- increase functioning and sense of well being in combat-trauma exposed OIF/OEF veterans.
Prazosin for Treating Noncombat Trauma Post-Traumatic Stress Disorder [Recruiting]
This study will evaluate the effectiveness of prazosin in treating post-traumatic stress
disorder caused by noncombat trauma in individuals taking selective serotonin reuptake
inhibitors.
Effect of Prazosin on Neurophysiology and Cognition in Post-Traumatic Stress Disorder (PTSD) [Not yet recruiting]
In this study, the investigators are looking at how PTSD affects things such as memory,
attention, reaction to sounds, eye movements, and heart rate. The investigators are also
studying whether a medication called prazosin has an effect on these things.
Study of the Medication Prazosin for Alcohol Dependence [Recruiting]
The purpose of this study is to determine whether the drug prazosin is effective for the
treatment of alcohol dependency.
Prazosin vs Paroxetine in Combat Stress-Related Post-Traumatic Stress Disorder (PTSD) Nightmares & Sleep Disturbance [Recruiting]
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