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Minipress (Prazosin Hydrochloride) - Summary



(prazosin hydrochloride)
For Oral Use

MINIPRESS® (prazosin hydrochloride), a quinazoline derivative, is the first of a new chemical class of antihypertensives.

MINIPRESS (prazosin hydrochloride) is indicated in the treatment of hypertension. It can be used alone or in combination with other antihypertensive drugs such as diuretics or beta adrenergic blocking agents.

See all Minipress indications & dosage >>


Published Studies Related to Minipress (Prazosin)

Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial. [2011.01.05]
OBJECTIVE: Envenomation by Mesobuthus tamulus scorpion sting can result in serious cardiovascular effects. Scorpion antivenom is a specific treatment for scorpion sting. Evidence for the benefit of scorpion antivenom and its efficacy compared with that of commonly used vasodilators, such as prazosin, is scarce. We assessed the efficacy of prazosin combined with scorpion antivenom, compared with prazosin alone, in individuals with autonomic storm caused by scorpion sting... CONCLUSION: Recovery from scorpion sting is hastened by simultaneous administration of scorpion antivenom plus prazosin compared with prazosin alone. TRIAL REGISTRATION NUMBER: CTRI/2010/091/000584 (Clinical Trials Registry India).

Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers. [2010.11]
Previous research has demonstrated cognitive-enhancing effects of modafinil in humans and generated evidence for its therapeutic potential in psychiatric disorders... Our findings support the hypothesised involvement of alpha1-adrenoceptors in some of the cognitive-enhancing effects of modafinil and warrant further investigation.

Efficacy of anti-scorpion venom serum over prazosin in the management of severe scorpion envenomation. [2010.10]
BACKGROUND: Scorpion venoms cause a massive release of neurotransmitters. Either anti-scorpion venom serum (AScVS) or prazosin has been used in the management of severe scorpion envenomation. AIMS: To compare the time taken for clinical recovery by patients with severe scorpion envenomation after AScVS therapy with that following prazosin therapy. SETTINGS AND DESIGN: A prospective, open-labeled clinical trial was undertaken to compare the effects of the AScVS and/or prazosin on clinical recovery in scorpion-stung patients... CONCLUSIONS: Intravenous slow bolus of AScVS given based on the clinical severity of envenomation leads to early recovery than prazosin alone and is well tolerated.

Prazosin versus quetiapine for nighttime posttraumatic stress disorder symptoms in veterans: an assessment of long-term comparative effectiveness and safety. [2010.06]
Posttraumatic stress disorder (PTSD) is an anxiety disorder experienced by combat veterans... Because of similar rate of short-term effectiveness, superior long-term effectiveness, and lower incidence of events leading to discontinuation, compared with quetiapine, prazosin should be used first-line for treating nighttime PTSD symptoms in a veteran population.

A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. [2009.02]
BACKGROUND: Current medications for alcohol dependence (AD) show only modest efficacy. None target brain noradrenergic pathways. Theory and preclinical evidence suggest that noradrenergic circuits may be involved in alcohol reinforcement and relapse. We therefore tested the alpha-1 adrenergic receptor antagonist, prazosin, as a pharmacotherapy for AD... CONCLUSIONS: Prazosin holds promise as a pharmacologic treatment for AD and deserves further evaluation in a larger controlled trial.

more studies >>

Clinical Trials Related to Minipress (Prazosin)

Monoamine Antagonist Therapies for Methamphetamine Abuse Prazosin [Recruiting]
This protocol will test the safety, effectiveness and the metabolism and action of prazosin as a potential therapy for methamphetamine abuse. This will be accomplished by performing a series of human laboratory studies. In each of these studies, the safety and effectiveness of the test medication (prazosin) in the treatment of methamphetamine effects will be determined. The study hypothesis is that prazosin will block the methamphetamine receptor function, reducing the reinforcing effects of central nervous system effects in humans.

Prazosin Treatment for Disruptive Agitation in Alzheimer's Disease [Recruiting]
A study of outpatient participants with Alzheimer's disease or a related dementia who have difficult behaviors that are upsetting for them or their caregivers. Prazosin is a medication that is commonly used to treat people with high blood pressure. Research with prazosin has shown that it may be effective in treating behavioral problems by reducing excess adrenalin effects in the brain.

Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) [Recruiting]
The purpose of this study is to determine whether prazosin will:

- reduce the incidence of nightmares and sleep disturbance

- increase functioning and sense of well being in combat-trauma exposed OIF/OEF veterans.

Prazosin for Treating Noncombat Trauma Post-Traumatic Stress Disorder [Recruiting]
This study will evaluate the effectiveness of prazosin in treating post-traumatic stress disorder caused by noncombat trauma in individuals taking selective serotonin reuptake inhibitors.

Study of the Medication Prazosin for Alcohol Dependence [Recruiting]
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.

more trials >>

Reports of Suspected Minipress (Prazosin) Side Effects

Hypoglycaemia (7)Metabolic Acidosis (7)Toxicity TO Various Agents (7)Intentional Overdose (4)Hypokalaemia (2)Hearing Impaired (2)Tachycardia (1)Fall (1)Chest Pain (1)Hypomagnesaemia (1)more >>

Page last updated: 2011-12-09

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