NEWS HIGHLIGHTS
Published Studies Related to Minipress (Prazosin)
Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial. [2011.01.05]
OBJECTIVE: Envenomation by Mesobuthus tamulus scorpion sting can result in serious cardiovascular effects. Scorpion antivenom is a specific treatment for scorpion sting. Evidence for the benefit of scorpion antivenom and its efficacy compared with that of commonly used vasodilators, such as prazosin, is scarce. We assessed the efficacy of prazosin combined with scorpion antivenom, compared with prazosin alone, in individuals with autonomic storm caused by scorpion sting... CONCLUSION: Recovery from scorpion sting is hastened by simultaneous administration of scorpion antivenom plus prazosin compared with prazosin alone. TRIAL REGISTRATION NUMBER: CTRI/2010/091/000584 (Clinical Trials Registry India).
Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers. [2010.11]
Previous research has demonstrated cognitive-enhancing effects of modafinil in humans and generated evidence for its therapeutic potential in psychiatric disorders... Our findings support the hypothesised involvement of alpha1-adrenoceptors in some of the cognitive-enhancing effects of modafinil and warrant further investigation.
Efficacy of anti-scorpion venom serum over prazosin in the management of severe scorpion envenomation. [2010.10]
BACKGROUND: Scorpion venoms cause a massive release of neurotransmitters. Either anti-scorpion venom serum (AScVS) or prazosin has been used in the management of severe scorpion envenomation. AIMS: To compare the time taken for clinical recovery by patients with severe scorpion envenomation after AScVS therapy with that following prazosin therapy. SETTINGS AND DESIGN: A prospective, open-labeled clinical trial was undertaken to compare the effects of the AScVS and/or prazosin on clinical recovery in scorpion-stung patients... CONCLUSIONS: Intravenous slow bolus of AScVS given based on the clinical severity of envenomation leads to early recovery than prazosin alone and is well tolerated.
Prazosin versus quetiapine for nighttime posttraumatic stress disorder symptoms in veterans: an assessment of long-term comparative effectiveness and safety. [2010.06]
Posttraumatic stress disorder (PTSD) is an anxiety disorder experienced by combat veterans... Because of similar rate of short-term effectiveness, superior long-term effectiveness, and lower incidence of events leading to discontinuation, compared with quetiapine, prazosin should be used first-line for treating nighttime PTSD symptoms in a veteran population.
A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. [2009.02]
BACKGROUND: Current medications for alcohol dependence (AD) show only modest efficacy. None target brain noradrenergic pathways. Theory and preclinical evidence suggest that noradrenergic circuits may be involved in alcohol reinforcement and relapse. We therefore tested the alpha-1 adrenergic receptor antagonist, prazosin, as a pharmacotherapy for AD... CONCLUSIONS: Prazosin holds promise as a pharmacologic treatment for AD and deserves further evaluation in a larger controlled trial.
Clinical Trials Related to Minipress (Prazosin)
AScVS and/ or Prazosin for Scorpion Envenomation [Completed]
The data available for the efficacy of AScVS and prazosin is generated through different
trials done in different clinical setting. Hence it was felt worthwhile to confirm the
documented efficacy of AScVS and prazosin in terms of time taken for clinical recovery in a
clinical trial. Along with this, effects of both the therapies on various biochemical
parameters will be recorded and compared with. It was also felt necessary to study the
effect of combination on the clinical outcome.
Varenicline + Prazosin for Heavy Drinking Smokers [Recruiting]
The purpose of this study is to examine the effect of varenicline and prazosin on smoking,
drinking, and sleep among cigarette smokers who report heavy alcohol use. Varenicline is an
FDA approved smoking cessation medication. Some smokers report sleep problems when taking
varenicline. This study will test whether using prazosin, which is an FDA-approved blood
pressure medication, in combination with varenicline reduces sleep problems that can be
associated with using varenicline for smoking cessation. In addition, the study will examine
the combined effects of these medications on smoking and drinking.
Hypothesis: Varenicline plus prazosin will result in lower rates of vivid dreams and
insomnia symptoms/sleep discontinuity than varenicline alone prior to the 3-day practice
quit attempt.
Hypothesis: Varenicline plus prazosin will result in lower rates of vivid dreams and
insomnia symptoms/sleep discontinuity than varenicline alone during the 3-day practice quit
attempt.
Prazosin as an Antimanic Agent in Severe Mania or Mixed States [Withdrawn]
Mania has been considered to be, in part, a hyperadrenergic state. One focus of treatment of
mania involves directly targeting this hyperexcitable state by reducing arousal with
antiadrenergic agents. This can be achieved by decreasing norepinephrine release by
stimulating presynaptic inhibitory receptors. Prazosin, FDA approved for the treatment of
high blood pressure works in part by blocking postsynaptic alpha-adrenergic receptors.
Prazosin has been found to be clinically useful for the treatment of Post Traumatic Stress
Disorder. It is reasonable, therefore, to anticipate that prazosin might be helpful in the
treatment of mania.
Monoamine Antagonist Therapies for Methamphetamine Abuse Prazosin [Completed]
This protocol will test the safety, effectiveness and the metabolism and action of prazosin
as a potential therapy for methamphetamine abuse. This will be accomplished by performing a
series of human laboratory studies. In each of these studies, the safety and effectiveness
of the test medication (prazosin) in the treatment of methamphetamine effects will be
determined. The study hypothesis is that prazosin will block the methamphetamine receptor
function, reducing the reinforcing effects of central nervous system effects in humans.
Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) [Completed]
The purpose of this study is to determine whether prazosin will:
- reduce the incidence of nightmares and sleep disturbance
- increase functioning and sense of well being in combat-trauma exposed Operation Iraqi
Freedom/Operation Enduring Freedom (OIF/OEF) Veterans.
Reports of Suspected Minipress (Prazosin) Side Effects
Hypoglycaemia (7),
Metabolic Acidosis (7),
Toxicity TO Various Agents (7),
Intentional Overdose (4),
Hypokalaemia (2),
Hearing Impaired (2),
Tachycardia (1),
Fall (1),
Chest Pain (1),
Hypomagnesaemia (1), more >>
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