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Microzide (Hydrochlorothiazide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The adverse reactions associated with hydrochlorothiazide have been shown to be dose related. In controlled clinical trials, the adverse events reported with doses of 12.5 mg hydrochlorothiazide once daily were comparable to placebo. The following adverse reactions have been reported for doses of hydrochlorothiazide 25 mg and greater and, within each category, are listed in the order of decreasing severity.

Body as a whole: Weakness.

Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).

Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.

Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.

Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.

Metabolic: Electrolyte imbalance (see PRECAUTIONS ), hyperglycemia, glycosuria, hyperuricemia.

Musculoskeletal: Muscle spasm.

Nervous System/Psychiatric: Vertigo, paresthesia, dizziness, headache, restlessness.

Renal: Renal failure, renal dysfunction, interstitial nephritis (see WARNINGS ).

Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.

Special Senses: Transient blurred vision, xanthopsia.

Urogenital: Impotence.

Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.



REPORTS OF SUSPECTED MICROZIDE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Microzide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Microzide side effects / adverse reactions in 77 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-10-26

Patient: 77 year old female

Reactions: Inappropriate Antidiuretic Hormone Secretion, Hyponatraemia, Asthenia

Suspect drug(s):
Medoxomil
    Indication: Product Used FOR Unknown Indication

Paroxetine HCL
    Indication: Product Used FOR Unknown Indication

Olmesartan Medoxomil

Microzide
    Indication: Product Used FOR Unknown Indication



Possible Microzide side effects / adverse reactions in 81 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-10-26

Patient: 81 year old female

Reactions: Confusional State, Hyponatraemia, Inappropriate Antidiuretic Hormone Secretion

Adverse event resulted in: death

Suspect drug(s):
Microzide
    Indication: Product Used FOR Unknown Indication

Pregabalin
    Indication: Product Used FOR Unknown Indication



Possible Microzide side effects / adverse reactions in 80 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-10-26

Patient: 80 year old female

Reactions: Orthostatic Hypotension, Hyponatraemia, Fall

Suspect drug(s):
Microzide



See index of all Microzide side effect reports >>

Drug label data at the top of this Page last updated: 2012-04-06

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