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Mevacor (Lovastatin) - Summary



MEVACOR (Lovastatin), is a cholesterol lowering agent isolated from a strain of Aspergillus terreus. After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding (beta)-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol.

MEVACOR is indicated for the following:

Therapy with MEVACOR should be a component of multiple risk factor intervention in those individuals with dyslipidemia at risk for atherosclerotic vascular disease. MEVACOR should be used in addition to a diet restricted in saturated fat and cholesterol as part of a treatment strategy to lower total-C and LDL-C to target levels when the response to diet and other nonpharmacological measures alone has been inadequate to reduce risk.

Primary Prevention of Coronary Heart Disease

In individuals without symptomatic cardiovascular disease, average to moderately elevated total-C and LDL-C, and below average HDL-C, MEVACOR is indicated to reduce the risk of:

  • Myocardial infarction
  • Unstable angina
  • Coronary revascularization procedures

(See CLINICAL PHARMACOLOGY, Clinical Studies.)

Coronary Heart Disease

MEVACOR is indicated to slow the progression of coronary atherosclerosis in patients with coronary heart disease as part of a treatment strategy to lower total-C and LDL-C to target levels.


Therapy with lipid-altering agents should be a component of multiple risk factor intervention in those individuals at significantly increased risk for artherosclerotic vascular disease due to hypercholesterolemia. MEVACOR is indicated as an adjunct to diet for the reduction of elevated total-C and LDL-C levels in patients with primary hypercholesterolemia (Types IIa and IIb***), when the response to diet restricted in saturated fat and cholesterol and to other nonpharmacological measures alone has been inadequate.

Adolescent Patients with Heterozygous Familial Hypercholesterolemia

MEVACOR is indicated as an adjunct to diet to reduce total-C, LDL-C and apolipoprotein B levels in adolescent boys and girls who are at least one year post-menarche, 10-17 years of age, with heFH if after an adequate trial of diet therapy the following findings are present:

  1. LDL-C remains >189 mg/dL or
  2. LDL-C remains >160 mg/dL and:
    • there is a positive family history of premature cardiovascular disease or
    • two or more other CVD risk factors are present in the adolescent patient

See all Mevacor indications & dosage >>


Published Studies Related to Mevacor (Lovastatin)

Lovastatin for the adjunctive treatment of schizophrenia: a preliminary randomized double-blind placebo-controlled trial. [2014]
While statins target many of the pathways to neuroprogression in schizophrenia, the safety and efficacy of statins for treating schizophrenia has never been examined. This is an 8-week randomized double blind controlled clinical trial examining the efficacy and safety of adjunctive lovastatin (20 mg/day) treatment or placebo for people with schizophrenia...

A randomized, double-blind, placebo-controlled phase II clinical trial of lovastatin for various endpoints of melanoma pathobiology. [2014]
On the basis of large cardiovascular clinical trials of lipid-lowering agents that showed a considerable decrease in the incidence of primary melanomas in the active agent arm, we have carried out a randomized, double-blind clinical trial examining the impact of lovastatin on various biomarkers of melanoma pathogenesis...

Augmentation of fluoxetine with lovastatin for treating major depressive disorder, a randomized double-blind placebo controlled-clinical trial. [2013]
BACKGROUNDS: There are contradictory evidence about the effect of statins on depression. This 6-week-randomized placebo-controlled clinical trial assessed the efficacy and safety of lovastatin as an adjuvant agent for treating major depressive disorder (MDD)... DISCUSSION: These results suggest that lovastatin as an adjuvant treatment may be effective for treating patients with MDD.

Thalidomide, dexamethasone and lovastatin with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma. [2011.10]
The treatment of patients with multiple myeloma usually includes many drugs including thalidomide, lenalidomide and bortezomib.Our results suggest that the addition of lovastatin to the TD regimen may improve the response rate in patients with relapsed or refractory myeloma.

Influence of one-year treatment with lovastatin on myocardial remodeling and ischemia in patients with coronary artery disease. [2011.02]
OBJECTIVE: Emerging evidence assumes that statins have a benefit to influence the myocardial remodeling and ischemia in patients with coronary artery disease (CAD). Our aim was to investigate the possible and direct favorable effects of lovastatin on left ventricular (LV) systolic, diastolic function and myocardial ischemia in patients with CAD... CONCLUSION: Lipid-lowering therapy with lovastatin improved the LV systolic function and decreased myocardial ischemia.

more studies >>

Clinical Trials Related to Mevacor (Lovastatin)

Lovastatin and Its �-hydroxy Acid From Four 600 mg LipoCol Forte� Capsules Compared to That of One 20 mg Mevacor� Tablet in Healthy Subjects [Completed]

Fed Bioavailability Study of Lovastatin Tablets and Mevacor Tablets [Completed]

Fasting Bioavailability Study of Lovastatin Tablets and Mevacor Tablets [Completed]

Evaluation of Interferon-Lovastatin Therapy for Malignant Melanoma [Withdrawn]
The purpose of this study is to determine whether an outpatient combination of lovastatin and low-to-moderate dose interferon is effective in the treatment of patients with malignant melanoma.

Phase II Trial - Breast Cancer Chemoprevention by Lovastatin [Terminated]
The purpose of the study is to determine whether oral lovastatin, used for 6 months, results in a decrease of abnormal breast duct cytology in women at high inherited breast cancer risk.

more trials >>

Reports of Suspected Mevacor (Lovastatin) Side Effects

Drug Ineffective (5)Abdominal Pain Upper (4)Muscle Spasms (4)Malaise (3)Completed Suicide (3)Myocardial Infarction (3)Pain in Extremity (3)Toxicity TO Various Agents (3)Abasia (2)Influenza Like Illness (2)more >>


Based on a total of 2 ratings/reviews, Mevacor has an overall score of 1.50. The effectiveness score is 3 and the side effect score is 2. The scores are on ten point scale: 10 - best, 1 - worst.

Mevacor review by 52 year old female patient

Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Extremely Severe Side Effects
Treatment Info
Condition / reason:   originally brain lesions then lower cholesterol
Dosage & duration:   10 mg increased to 20mg taken nightly for the period of 3 years
Other conditions:   multiple schlerosis
Other drugs taken:   imipramine & wellbutrin
Reported Results
Benefits:   I believe the treatment at the lower 10 mg dose was effective in reducing the serverity of my brain lesions. I also believe I was thinking more clearly afterwards than I was prior to starting on lovastatin. A brain MRI taken a year after starting on Lovastatin indicated the lesions had reduced a bit, but that was not confirmed by my doctor as my previous MRI had been lost when I changed doctors.
Side effects:   After increasing the dosage to 20 mgs to also reduce my cholesterol levels, I started to experience extreme pain in my arm muscles.
Comments:   Originally I started taking it to see if it would have any positive effect on the number and size of brain lesions I had. I had experienced an increasing inability to handle job stress, was losing my concentration abilities and was becoming increasingly forgetful. I believe it did have some positive effect in reducing the size and number of brain lesions, but not to the effect of improving my cognitive thinking ability to the extent I could return to work. Two years later, my doctor wanted me to increase the dosage to reduce my cholesterol levels. Shortly after increasing my dosage, I started to experience chronic pain in my arms. I finally did some research and discovered muscle pain to be a "side effect" when taking statin drugs. When I stopped taking Lovastatin, the pain went away after a few months.


Mevacor review by 51 year old female patient

Overall rating:  
Effectiveness:   Ineffective
Side effects:   Extremely Severe Side Effects
Treatment Info
Condition / reason:   high cholesterol
Dosage & duration:   60 mg taken once a day for the period of month
Other conditions:   high blood pressure
Other drugs taken:   vasotec
Reported Results
Benefits:   NONE!!!!!
Side effects:   I began having very irregular heart rhythm within about 2 1/2 weeks of taking this medicine. Feeling like I was going to pass out or maybe my heart would even stop beating.
Comments:   I began having very irregular heart rhythm within about 2 1/2 weeks of taking this medicine. I began feeling like I was going to pass out or maybe my heart would stop beating & I would just keel over & die if I didn't immediately start moving around. I could be sitting or laying down in bed & these "spells" would come on out of the blue & very regularly. I spent one night up all night laying on the couch because it was so bad that I was afraid that if I fell asleep I might not wake up. I tried to pretend it would go way at first but then made an appointment with my Dr. first & then a cardiologist, it was just too scary. My Dr. didn't believe that it was the medicine. By the time I could get in to see the cardiologist & have the heart monitor holster, echocardiogram etc. done I had been off the medicine for 2 weeks & the symptoms had lessened & of course did not appear while I was being tested. The Dr. thought I was crazy & that there was no way it was the medicine & that maybe I was having panic attacks. I have never had a panic attack in my life & I have had similar heart rhythm symptoms with other meds that quit when I stopped taking them & I know my own body. It WAS the lovastatin. It took a year & a half before I started feeling normal again & didn't have these attacks come on sometimes. I truly believe the lovastatin had an affect on my heart that took that long to get better. I will NEVER take another cholesterol med again that has the possible side affects of affecting muscles. The heart is a muscle. I also found that other people have had this same experience while taking statins while I was researching this on the internet. Neither Dr. would even look at the article I printed out about it & it was even written by another Dr. who was researching statin side affects.

See all Mevacor reviews / ratings >>

Page last updated: 2015-08-10

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