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Metronidazole (Metronidazole) - Summary

 
 



METRONIDAZOLE SUMMARY

Metronidazole Topical Cream contains metronidazole, USP, at a concentration of 7.5 mg per gram (0.75%) in an emollient cream consisting of emulsifying wax, sorbitol solution, glycerin, isopropyl palmitate, benzyl alcohol, lactic acid and/or sodium hydroxide to adjust pH, and purified water.   Metronidazole is a member of the imidazole class of antibacterial agents and isclassified therapeutically as an antiprotozoal and antibacterial agent.

Metronidazole Topical Cream is indicated for topical application in the treatment of inflammatory papules and pustules of rosacea.


See all Metronidazole indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Metronidazole

Efficacy and safety of metronidazole for pulmonary multidrug-resistant tuberculosis. [2013]
Pulmonary lesions from active tuberculosis patients are thought to contain persistent, nonreplicating bacilli that arise from hypoxic stress... Newer nitroimidazoles with both aerobic and anaerobic activity, now in clinical trials, may increase the sterilizing potency of future treatment regimens.

Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis - a pilot study. [2013]
in patients with PSC... CONCLUSIONS: Both vancomycin and metronidazole demonstrated efficacy; however,

Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial. [2011.09]
AIM: To evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ+amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP)... CONCLUSION: The adjunctive use of MTZ+AMX offers short-term clinical and microbiological benefits, over SRP alone, in the treatment of non-smokers subjects with generalized ChP. The added benefits of MTZ were less evident. (c) 2011 John Wiley & Sons A/S.

Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. [2011.03.12]
BACKGROUND: Helicobacter pylori is associated with benign and malignant diseases of the upper gastrointestinal tract, and increasing antibiotic resistance has made alternative treatments necessary. Our aim was to assess the efficacy and safety of a new, single-capsule treatment versus the gold standard for H pylori eradication... INTERPRETATION: Quadruple therapy should be considered for first-line treatment in view of the rising prevalence of clarithromycin-resistant H pylori, especially since quadruple therapy provides superior eradication with similar safety and tolerability to standard therapy. FUNDING: Axcan Pharma Inc. Copyright (c) 2011 Elsevier Ltd. All rights reserved.

Tinidazole vs metronidazole for the treatment of bacterial vaginosis. [2011.03]
OBJECTIVE: The purpose of this study was to compare the efficacy of 2 different doses of tinidazole with metronidazole for the treatment of bacterial vaginosis and to compare the side effects of the drugs... CONCLUSION: There were no differences in cure rates between metronidazole and either of the tinidazole dosing regimens that were studied. In addition, there were no important differences in the side-effect profiles of metronidazole and tinidazole. Copyright (c) 2011 Mosby, Inc. All rights reserved.

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Clinical Trials Related to Metronidazole

A Safety, Tolerability and Pharmacokinetic Study of Two Formulations of Metronidazole Versus Immediate Release Metronidazole in Patient With C. Difficile Colitis [Completed]
Clostridium difficile bacteria can be a cause of significant diarrheal disease, particularly in people who have taken potent antibiotics. When C. difficile multiplies within the colon, it produces two toxins that cause inflammation and resultant abdominal pain, fever and diarrhea. Current treatment of mild to moderate disease is with immediate release metronidazole, an antibiotic that kills C. difficile. Dr. Reddy's Laboratories has developed a delayed release form of metronidazole to release just before the colon to increase the concentration of antibiotic in the colon to improve the effectiveness of metronidazole treatment and potentially to allow less whole body exposure to the antibiotic. This study will measure the amount of metronidazole in the blood and stool of patients with C. difficile associated diarrhea (CDAD) to confirm that the new formulations are releasing the antibiotic as designed, immediately before the colon.

Penicillin and Metronidazole in Treatment of Peritonsillar Abscess [Completed]
Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage we perform a prospective, double blind, placebo-controlled, randomised study on 200 adult patients with peritonsillar abscess. 100 patients are given penicillin and metronidazole and 100 patients get penicillin and placebo. Recovery and recurrence and analyzed.

A Study to Assess the Levels of CAZ-AVI and Metronidazole in the Blood When Given Together and Separately [Completed]
The purpose of the study is to assess whether there is any pharmacokinetic interactions between CAZ-AVI and metronidazole.

Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies [Recruiting]
Abnormal vaginal flora is a risk factor for preterm labor. Therefore, in high risk pregnancies for preterm labor the diagnosis and treatment of abnormal flora is indicated. Clindamycin and metronidazole given orally are both acceptable treatments in these cases. The purpose of this study is to compare the effectiveness of Clindamycin Vs metronidazole for the treatment of abnormal vaginal flora in high risk pregnancies. For this purpose, pregnant women who are considered high risk for preterm labor and were diagnosed with abnormal vaginal flora will be randomly treated either with clindamycin or metronidazole. Eradication of the abnormal flora and adverse effects will be monitored and compared

Effectiveness of Metronidazole in Pain Control Posthemorrhoidectomy [Completed]
Hemorrhoidal disease occurs in 50% of people over 40 years old and is the most common cause of anorectal surgery. One of the complications of hemorrhoidectomy is pain, which is a difficult symptom to appreciate and assess, by its frequent and large variations in sensitivity in each patient. Many studies have been done to reduce patient postoperative pain, but there is no ideal method. The application of both oral and topical metronidazole has shown to decrease pain following hemorrhoidectomy, but its use is not standardized. The investigators evaluated the effect of oral administration of metronidazole versus homologated placebo in pain control after hemorrhoidectomy

more trials >>

Reports of Suspected Metronidazole Side Effects

Vomiting (66)Nausea (56)Pyrexia (31)Toxic Encephalopathy (31)Dizziness (30)Diarrhoea (30)Dysarthria (29)Hepatotoxicity (27)Oedema (26)Drug Rash With Eosinophilia and Systemic Symptoms (25)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 8 ratings/reviews, Metronidazole has an overall score of 5. The effectiveness score is 7.25 and the side effect score is 4. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Metronidazole review by 18 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   Tooth Abscess
Dosage & duration:   400 MG taken 3 times daily. for the period of 1 Week.
Other conditions:   N/A
Other drugs taken:   Amoxocillin
  
Reported Results
Benefits:   Personally, i found metronidazole to be an equivalent to a concentration drug, it severely improved my intelligence and my overall concentration, i realise now that this drug, as it may be depressing, a new chapter in my life. during the medication i received, i was severely depressed, however it got me thinking deeply towards why i was indeed depressed, and thus, i came to a solution. it completely destroyed the bacteria that was within my abscess and treated me within 3 days, and aided my mind alot. Within my experience with metronidazole, i have only to thank it for my A* papers and my mental health. With that i have only this to say: Take it, it aids the physical problems you have, and if your like me at all, with greater ambitions than any human can dream, This will make you realise all the problems you encounter, and it will cleanse you of your worries.
Side effects:   The side effects are the same as the benefits to me.
Comments:   400 MG 3 Times DAILY NOT to be taken with any alchohol. 7 Day period.

 

Metronidazole review by 30 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Dog bite prophylaxis
Dosage & duration:   500mg taken 3x daily for the period of 8 days
Other conditions:   None
Other drugs taken:   Doxycycline HC
  
Reported Results
Benefits:   Apparently prevented wound infection, though efficacy of drug is questionable and causality cannot be established.
Side effects:   Side effects were severe. Consistent metallic taste in mouth, upset stomach, sleep difficulties, diarrhea, severe dizziness and anxiety. Transient dry mouth. General feeling of being "spacey" and unfocused.
Comments:   Took metronidazole to preclude infection after a puncture wound from a dog bite. Did not tolerate medication; ceased therapy after 8 days.

 

Metronidazole review by 31 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   Bacterial Lung Infection
Dosage & duration:   1 table 3x a day taken 6hrs for the period of 3
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I was not able to take the drug long enough to know its benefits.
Side effects:   I took my first dose before bed one night. In the morning I woke with a cold sore and a very large ulcer on my tongue. I attributed this to the slight fever I had been running periodically. My tongue became increasingly sore. The second pill, later on that day, caused sever stomach pain, cramping, diarhea, nausea, and hot flashes. The oral pain remained about the same. I took the third, and last, dose that afternoon is the worst experience I have ever had with a drug. Immediately after taking the pill blisters began to appear wherever the pill had touched my skin. This included the entirety of my tongue, mouth, lips, and throat. I called the PA that had prescribed the drug and told her about the reaction. She told me to discontinue the drug immediately and that was a possible side effect of this drug. Had I any idea what it was going to be like, and the intense pain I would endure because of it, thenI would never have taken it.
Comments:   I took 3 pills. That is all.

See all Metronidazole reviews / ratings >>

Page last updated: 2014-11-30

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