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Metrogel (Metronidazole Topical Gel) - Summary

 
 



METROGEL SUMMARY

METROGEL (metronidazole) Gel, 1% contains metronidazole, USP.

METROGEL® is indicated for the topical treatment of inflammatory lesions of rosacea.

See all Metrogel indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Metrogel (Metronidazole Topical)

Efficacy and safety of metronidazole for pulmonary multidrug-resistant tuberculosis. [2013]
Pulmonary lesions from active tuberculosis patients are thought to contain persistent, nonreplicating bacilli that arise from hypoxic stress... Newer nitroimidazoles with both aerobic and anaerobic activity, now in clinical trials, may increase the sterilizing potency of future treatment regimens.

Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis - a pilot study. [2013]
in patients with PSC... CONCLUSIONS: Both vancomycin and metronidazole demonstrated efficacy; however,

Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial. [2011.09]
AIM: To evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ+amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP)... CONCLUSION: The adjunctive use of MTZ+AMX offers short-term clinical and microbiological benefits, over SRP alone, in the treatment of non-smokers subjects with generalized ChP. The added benefits of MTZ were less evident. (c) 2011 John Wiley & Sons A/S.

Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. [2011.03.12]
BACKGROUND: Helicobacter pylori is associated with benign and malignant diseases of the upper gastrointestinal tract, and increasing antibiotic resistance has made alternative treatments necessary. Our aim was to assess the efficacy and safety of a new, single-capsule treatment versus the gold standard for H pylori eradication... INTERPRETATION: Quadruple therapy should be considered for first-line treatment in view of the rising prevalence of clarithromycin-resistant H pylori, especially since quadruple therapy provides superior eradication with similar safety and tolerability to standard therapy. FUNDING: Axcan Pharma Inc. Copyright (c) 2011 Elsevier Ltd. All rights reserved.

Tinidazole vs metronidazole for the treatment of bacterial vaginosis. [2011.03]
OBJECTIVE: The purpose of this study was to compare the efficacy of 2 different doses of tinidazole with metronidazole for the treatment of bacterial vaginosis and to compare the side effects of the drugs... CONCLUSION: There were no differences in cure rates between metronidazole and either of the tinidazole dosing regimens that were studied. In addition, there were no important differences in the side-effect profiles of metronidazole and tinidazole. Copyright (c) 2011 Mosby, Inc. All rights reserved.

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Clinical Trials Related to Metrogel (Metronidazole Topical)

A Safety, Tolerability and Pharmacokinetic Study of Two Formulations of Metronidazole Versus Immediate Release Metronidazole in Patient With C. Difficile Colitis [Completed]
Clostridium difficile bacteria can be a cause of significant diarrheal disease, particularly in people who have taken potent antibiotics. When C. difficile multiplies within the colon, it produces two toxins that cause inflammation and resultant abdominal pain, fever and diarrhea. Current treatment of mild to moderate disease is with immediate release metronidazole, an antibiotic that kills C. difficile. Dr. Reddy's Laboratories has developed a delayed release form of metronidazole to release just before the colon to increase the concentration of antibiotic in the colon to improve the effectiveness of metronidazole treatment and potentially to allow less whole body exposure to the antibiotic. This study will measure the amount of metronidazole in the blood and stool of patients with C. difficile associated diarrhea (CDAD) to confirm that the new formulations are releasing the antibiotic as designed, immediately before the colon.

Penicillin and Metronidazole in Treatment of Peritonsillar Abscess [Completed]
Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage we perform a prospective, double blind, placebo-controlled, randomised study on 200 adult patients with peritonsillar abscess. 100 patients are given penicillin and metronidazole and 100 patients get penicillin and placebo. Recovery and recurrence and analyzed.

A Study to Assess the Levels of CAZ-AVI and Metronidazole in the Blood When Given Together and Separately [Completed]
The purpose of the study is to assess whether there is any pharmacokinetic interactions between CAZ-AVI and metronidazole.

Bioequivalence of Metronidazole Gel, 0.75% in the Treatment of Bacterial Vaginosis [Completed]
The purpose of this study was to demonstrate comparable efficacy, safety, and tolerability of Teva Pharmaceuticals USA's generic formulation of Metronidazole Vaginal Gel, 0. 75% and 3M Pharmaceuticals' MetroGel-Vaginal« metronidazole vaginal gel, 0. 75% to establish clinical equivalence in the treatment of bacterial vaginosis.

Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies [Recruiting]
Abnormal vaginal flora is a risk factor for preterm labor. Therefore, in high risk pregnancies for preterm labor the diagnosis and treatment of abnormal flora is indicated. Clindamycin and metronidazole given orally are both acceptable treatments in these cases. The purpose of this study is to compare the effectiveness of Clindamycin Vs metronidazole for the treatment of abnormal vaginal flora in high risk pregnancies. For this purpose, pregnant women who are considered high risk for preterm labor and were diagnosed with abnormal vaginal flora will be randomly treated either with clindamycin or metronidazole. Eradication of the abnormal flora and adverse effects will be monitored and compared

more trials >>

Reports of Suspected Metrogel (Metronidazole Topical) Side Effects

Diverticulitis (2)Abasia (1)Skin Burning Sensation (1)Headache (1)Dermatitis (1)Back Pain (1)Nausea (1)Pain in Extremity (1)Drug Hypersensitivity (1)Musculoskeletal Pain (1)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 19 ratings/reviews, Metrogel has an overall score of 4.74. The effectiveness score is 5.47 and the side effect score is 8.42. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Metrogel review by 51 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   acne rosacea
Dosage & duration:   .75% (dosage frequency: twice a day) for the period of approx six months
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   I'd had dry skin on my face for several years which I'd controlled using moisturisers. About five years ago, I started to get acne pimples and bumps on my cheeks and forehead which was diagnosed as rosacea. I was prescribed Metrogel which cleared the problems, including the dry skin. Symptoms reduced almost immediately. I've had about two years without having to get a repeat prescription, and symptoms have just begun to return, so I've requested more from my doc.
Side effects:   The gel can be visible if applied too thickly, at which point it can flake slightly.
Comments:   Apply a thin layer of gel to the face twice a day.

 

Metrogel review by 56 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   rosacea
Dosage & duration:   .75 (dosage frequency: 2 years) for the period of 2 years
Other conditions:   diabetes
Other drugs taken:   metformin
  
Reported Results
Benefits:   Sometimes lessoned redness
Side effects:   burning sensation on occasion
Comments:   Several years ago I was diagnosed with rosacea. Metrogel was prescribed by my family doctor. At the time I had oily skin. It was prescribed to be used 2 times a day. I was also told to use Cetaphil cleanser. My rosacea symptoms were redness, burning skin that felt hot to the touch. I used the Metrogel religiously as prescribed. For the first 2 weeks, it burned on contact. I hated it. After awhile my skin started calming down and I stopped using the Metrogel. Everytime my skin flared up I would use it again. I'm using it right now. I can't really say if the Metrogel helped at all. Sometimes I think it is very irritating but I'm told to use it when necessary. Redness is sometimes better after use, but I don't know if it the result of the Metrogel. I would like to find something better out there.

 

Metrogel review by 60 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   skin texture changes due to rosacea
Dosage & duration:   pea-size amount to face (dosage frequency: twice a day) for the period of 2 yrs.
Other conditions:   none
Other drugs taken:   synthroid
  
Reported Results
Benefits:   None
Side effects:   none
Comments:   Metrogel was applied after cleansing, before applying moisturizer. This was done twice a day, morning and evening. There was no change in the 'bumps' that were on my face, and there was no change in the progression of others that were forming. I religiously used this get for two years before stopping treatment. Using Metrogel was a complete waste of time for me.

See all Metrogel reviews / ratings >>

Page last updated: 2014-11-30

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