One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g.
Oral LD50 in animals (mg/kg): rats, 521; maximum tolerated intravenous dose in one dog, 300.
Signs and Symptoms
The clinical picture of poisoning with Metopirone is characterized by gastrointestinal symptoms and by signs of acute adrenocortical insufficiency.
Cardiovascular System: Cardiac arrhythmias, hypotension, dehydration.
Nervous System and Muscles: Anxiety, confusion, weakness, impairment of consciousness.
Gastrointestinal System: Nausea, vomiting, epigastric pain, diarrhea.
Laboratory Findings: Hyponatremia, hypochloremia, hyperkalemia.
In patients under treatment with insulin or oral antidiabetics, the signs and symptoms of acute poisoning with Metopirone may be aggravated or modified.
There is no specific antidote. Besides general measures to eliminate the drug and reduce its absorption, a large dose of hydrocortisone should be administered at once, together with saline and glucose infusions.
Surveillance: For a few days blood pressure and fluid and electrolyte balance should be monitored.