Metolazone (Metolazone) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Metolazone is usually well tolerated, and most reported adverse reactions have been mild and transient. Many metolazone related adverse reactions represent extensions of its expected pharmacologic activity and can be attributed to either its antihypertensive action or its renal/metabolic actions. The following adverse reactions have been reported. Several are single or comparably rare occurrences. Adverse reactions are listed in decreasing order of severity within body systems.

Cardiovascular: Chest pain/discomfort, orthostatic hypotension, excessive volume depletion, hemoconcentration, venous thrombosis, palpitations.

Central and Peripheral Nervous System: Syncope, neuropathy, vertigo, paresthesias, psychotic depression, impotence, dizziness/lightheadedness, drowsiness, fatigue, weakness, restlessness (sometimes resulting in insomnia), headache.

Dermatologic/Hypersensitivity: Toxic epidermal necrolysis (TEN), Stevens-Johnson Syndrome, necrotizing angiitis (cutaneous vasculitis), skin necrosis, purpura, petechiae, dermatitis (photosensitivity), urticaria, pruritus, skin rashes.

Gastrointestinal: Hepatitis, intrahepatic cholestatic jaundice, pancreatitis, vomiting, nausea, epigastric distress, diarrhea, constipation, anorexia, abdominal bloating, abdominal pain.

Hematologic: Aplastic/hypoplastic anemia, agranulocytosis, leukopenia, thrombocytopenia.

Metabolic: Hypokalemia, hyponatremia, hyperuricemia, hypochloremia, hypochloremic alkalosis, hyperglycemia, glycosuria, increase in serum urea nitrogen (BUN) or creatinine, hypophosphatemia, hypomagnesemia, hypercalcemia.

Musculoskeletal: Joint pain, acute gouty attacks, muscle cramps or spasm.

Other: Transient blurred vision, chills, dry mouth.

In addition, adverse reactions reported with similar antihypertensive-diuretics, but which have not been reported to date for metolazone include: bitter taste, sialadenitis, xanthopsia, respiratory distress (including pneumonitis), and anaphylactic reactions. These reactions should be considered as possible occurrences with clinical usage of metolazone.

Whenever adverse reactions are moderate or severe, metolazone dosage should be reduced or therapy withdrawn.

REPORTS OF SUSPECTED METOLAZONE SIDE EFFECTS / ADVERSE REACTIONS

Possible Metolazone side effects / adverse reactions in 52 year old female

Reported by a physician from United States on 2011-10-03

Patient: 52 year old female weighing 52.0 kg (114.4 pounds)

Reactions: Cardiac Failure, Concomitant Disease Progression, Disease Progression, Renal Failure Acute

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Imatinib Mesylate
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2011-05-11
    End date: 2011-07-13

Metolazone

Imatinib Mesylate
    Dosage: 200 mg, qd
    Administration route: Oral
    Start date: 2011-07-13
    End date: 2011-07-15

Possible Metolazone side effects / adverse reactions in 71 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-21

Patient: 71 year old female

Reactions: Ventricular Extrasystoles, Dyspnoea, Eye Oedema, Drug Interaction, Mental Impairment, Malaise, Diarrhoea, Blood Electrolytes Abnormal, Visual Impairment, Oedema, Nasal Disorder, Blood Creatinine Increased

Suspect drug(s):
Lorazepam
    Indication: Product Used FOR Unknown Indication

Metolazone

Potassium Chloride
    Indication: Product Used FOR Unknown Indication

Folic Acid
    Indication: Product Used FOR Unknown Indication

Diltiazem HCL
    Indication: Product Used FOR Unknown Indication

Bumetanide
    Indication: Product Used FOR Unknown Indication

Spironolactone
    Indication: Product Used FOR Unknown Indication

Cetirizine HCL
    Indication: Product Used FOR Unknown Indication

Tikosyn
    Indication: Atrial Fibrillation

Latanoprost
    Indication: Product Used FOR Unknown Indication

Metoprolol Succinate
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Indication: Product Used FOR Unknown Indication

Warfarin Sodium
    Indication: Product Used FOR Unknown Indication

Possible Metolazone side effects / adverse reactions in 71 year old female

Reported by a consumer/non-health professional from United States on 2011-10-24

Patient: 71 year old female

Reactions: Ventricular Extrasystoles, Dyspnoea, Eye Oedema, Drug Interaction, Mental Impairment, Malaise, Diarrhoea, Blood Electrolytes Abnormal, Visual Impairment, Oedema, Nasal Disorder, Blood Creatinine Increased

Suspect drug(s):
Folic Acid
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Cetirizine HCL
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Bumetanide
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Tikosyn
    Dosage: (df)
    Indication: Atrial Fibrillation

Spironolactone
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Potassium Chloride
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Warfarin Sodium
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Metoprolol Succinate
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Diltiazem HCL
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Latanoprost
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Metolazone
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication

Lorazepam
    Dosage: (df)
    Indication: Product Used FOR Unknown Indication