Metoclopramide (Metoclopramide Hydrochloride) - Summary

METOCLOPRAMIDE SUMMARY

Metaclopramide Injection, USP
Rx Only

Metoclopramide hydrochloride is a white crystalline, odorless substance, freely soluble in water.

Diabetic Gastroparesis (Diabetic Gastric Stasis)

Metoclopramide Injection is indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis.

The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy

Metoclopramide Injection is indicated for the prophylaxis of vomiting associated with emetogenic cancer chemotherapy.

The Prevention of Postoperative Nausea and Vomiting

Metoclopramide Injection is indicated for the prophylaxis of postoperative nausea and vomiting in those circumstances where nasogastric suction is undesirable.

Small Bowel Intubation

Metoclopramide Injection may be used to facilitate small bowel intubation in adults and pediatric patients in whom the tube does not pass the pylorus with conventional maneuvers.

Radiological Examination

Metoclopramide Injection may be used to stimulate gastric emptying and intestinal transit of barium in cases where delayed emptying interferes with radiological examination of the stomach and/or small intestine.

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NEWS HIGHLIGHTS

Media Articles Related to Metoclopramide

Metoclopramide Drugs Get 'Black Box' Warning
Source: MedicineNet Gastroparesis Specialty [2009.03.02]
Title: Metoclopramide Drugs Get 'Black Box' Warning
Category: Health News
Created: 3/2/2009
Last Editorial Review: 3/2/2009

FDA Approves New Salix Product Exclusively In Catalent's Zydis(R) Fast Dissolve Technology
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.04]
Catalent Pharma Solutions, one of the leading advanced drug delivery technology providers to the pharmaceutical industry, announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Metozolv™ ODT (orally disintegrating tablets) metoclopramide HCL utilizing Catalent's Zydis® fast dissolve technology. Metozolv™ ODT was developed by Wilmington Pharmaceuticals and licensed to Salix Pharmaceuticals.

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Published Studies Related to Metoclopramide

Comparison of the efficacy of propofol and metoclopramide in preventing postoperative nausea and vomiting after middle ear surgery. [2009.06]
OBJECTIVE: To compare the administration of sub hypnotic dose of propofol with metoclopramide and placebo in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery... CONCLUSION: The administration of a sub hypnotic dose of propofol at the end of surgery was found to be at least as effective as metoclopramide in preventing PONV in the early postoperative period in adult patients undergoing middle ear surgery.

Slower infusion of metoclopramide decreases the rate of akathisia. [2009.05]
OBJECTIVE: We investigated the difference in incidence of acute akathisia related to the rate of infusion in patients receiving metoclopramide for acute nausea, vomiting, or migraine headache in the emergency department (ED)... CONCLUSIONS: Slower infusion of metoclopramide reduces the incidence of akathisia.

A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients. [2009.03]
STUDY OBJECTIVE: Akathisia, an adverse effect observed at times after administration of parenteral metoclopramide, is an unpleasant symptom complex characterized by restlessness and agitation. Some try to limit the development of akathisia by coadministering diphenhydramine when using parenteral metoclopramide. The goal of this investigation is to determine whether concomitant administration of diphenhydramine 25 mg decreased the rate of development of akathisia after administration of 10 mg or 20 mg of intravenous metoclopramide... CONCLUSION: Routine prophylaxis with diphenhydramine to prevent akathisia is unwarranted when intravenous metoclopramide is administered over 15 minutes. For patients administered 20 mg of metoclopramide, prophylactic diphenhydramine may decrease subjective restlessness.

The Effect of Metoclopramide in Capsule Enteroscopy. [2009.01.29]
Clinical utility of prokinetics in capsule endoscopy (CE) is not clearly established. The objective of this prospective, randomized, single-blind, controlled trial was to determine if metoclopramide is useful in CE by increasing the rate of complete enteroscopy...

A randomized controlled trial of prochlorperazine versus metoclopramide for treatment of acute migraine. [2008.10]
STUDY OBJECTIVE: We compare prochlorperazine 10 mg intravenously versus metoclopramide 20 mg intravenously for the emergency department (ED) treatment of acute migraine... CONCLUSION: Either prochlorperazine 10 mg intravenously or metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, is an efficacious treatment for ED patients with acute migraine. Three quarters of subjects in both arms would want the same medication for their next migraine.

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Clinical Trials Related to Metoclopramide

A Randomized, Open-Label, Two-Way Crossover Trial to Determine the Pharmacokinetics of Metoclopramide When Administered as the Orally Disintegrating Tablet Compared to Reglan® Tablets in Subjects With Diabetic Gastroparesis [Completed]
To determine whether a new Orally Disintegrating Tablet of Reglan (metoclopramide) is metabolized faster than the conventional Reglan tablet in patients with diabetic gastroparesis, pharmacokinetics following a single 10 mg dose of each formulation are being compared. Subjects must be 18 or older, have Type 1 or 2 diabetes with documented gastroparesis and agree to withhold medications for gastroparesis for 3 days prior to each dosing. Exclusion criteria include serum glucose >300 mg/dL, Hb1Ac >10%, and concurrent illness interfering with gastrointestinal motility. Subjects will stay in the clinic overnight, and pharmacokinetic sampling will continue for 8 hours after the first morning dose. The time (Tmax) and amount (Cmax) of peak concentration and the area under the curve (AUC) from time zero to 8 hr will be compared for the 2 formulations.

Metoclopramide Use in Very Low Birth Weight Newborns [Completed]
During the first 7 days of life very small babies will receive the drug metoclopramide or a salt solution through an intravenous line. They will also begin to receive a very small amount of breast milk or formula within the first 72 hours of life, in addition toother nourishment that is provided by an intravenous line, according to standard hospital procedure. We think that the babies who receive the medication may reach full oral feeds than babies who receive the salt solution.

MgSO4 vs Metoclopramide for Headache in Pregnant Women [Recruiting]
The study will compare effectiveness of intravenous magnesium sulfate to that of intravenous metoclopramide (Reglan®) for acute headache in pregnant women. We will randomize pregnant women who present to our emergency department with chief complaint of headache to magnesium sulfate 2 grams intravenously or metoclopramide 10 mg intravenously; both groups will receive acetaminophen (Tylenol®) 1 gram orally and normal saline 1 liter intravenously. Headaches are common during pregnancy, related to hormonal changes, altered sleep patterns and psychosocial stressors. Common medications for headache such as non-steroidal antiinflammatories or triptans are typically avoided during pregnancy due to concern for fetal effects. Women, and their physicians, are often uncertain regarding available medication options with justifiable safety profiles during pregnancy.

Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED [Recruiting]

Metoclopramide for Acute Migraine: A Dose Finding Study [Recruiting]
Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do not know the bets dose to administer. This study compares three different doses of metoclorpamide.

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PATIENT REVIEWS / RATINGS / COMMENTS

Metoclopramide review by 56 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		nausea
Dosage & duration:		10mg oral taken every 6 hours for the period of 1 day
Other conditions:		Nil
Other drugs taken:		No other drugs
		Reported Results
Benefits:		There were no treatment benefits from this particular drug. My nausea was not controlled at all, in fact I felt more nauseaus after taking the medication.
Side effects:		I had severe restlessness, developed an intense feeling of anxiety, had an extreme desire to sit down, then lay down and went on to develop a dystonic reaction. I developed an intense feeling of doom, my stomach had feelings of cramps, knotting and pain. My neck felt tense and the ambulance was called and I was taken to the emergency dept of local hospital.
Comments:		Ambulance officers gave me pain relief and this settled my stomach of the knotting and cramping/pain. This also settled the feeling of doom. In emergency, after numerous examinations and questionning, abdo xray, I was given IV hydration x 2 litres and Ondansetron IV x 2 - 8 hours apart. I was observed in emergency overnight and went home the next morning with no side effects at all. Never will I take maxalon again!