SUMMARY
Methylprednisolone Tablets contain methylprednisolone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.
Methylprednisolone Tablets are indicated in the following conditions: 1. Endocrine Disorders
Congenital adrenal hyperplasia Nonsuppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Synovitis of osteoarthritis Acute nonspecific tenosynovitis Post-traumatic osteoarthritis Psoriatic arthritis Epicondylitis Acute gouty arthritis 3. Collagen Diseases
During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis 4. Dermatologic Diseases
Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Severe seborrheic dermatitis Exfoliative dermatitis Mycosis fungoides Pemphigus Severe psoriasis 5. Allergic States
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis Drug hypersensitivity reactions Serum sickness Contact dermatitis Bronchial asthma Atopic dermatitis 6. Ophthalmic Diseases
Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: Allergic corneal marginal ulcers Herpes zoster ophthalmicus Anterior segment inflammation Diffuse posterior uveitis and choroiditis Sympathetic ophthalmia Keratitis Optic neuritis Allergic conjunctivitis Chorioretinitis Iritis and iridocyclitis 7. Respiratory Diseases
Symptomatic sarcoidosis Berylliosis Loeffler's syndrome not manageable by other means Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy Aspiration pneumonitis 8. Hematologic Disorders
Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia Erythroblastopenia (RBC anemia) Congenital (erythroid) hypoplastic anemia 9. Neoplastic Diseases
For palliative management of: Leukemias and Iymphomas in adults Acute leukemia of childhood 10. Edematous States
To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. 11. Gastrointestinal Diseases
To tide the patient over a critical period of the disease in: Ulcerative colitis Regional enteritis 12. Nervous System
Acute exacerbations of multiple sclerosis 13. Miscellaneous
Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Trichinosis with neurologic or myocardial involvement.
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NEWS HIGHLIGHTS
Published Studies Related to Methylprednisolone
Double-blind, placebo-controlled pilot randomized trial of methylprednisolone
infusion in pediatric acute respiratory distress syndrome. [2015] syndrome... CONCLUSION: This study demonstrates the feasibility of administering low-dose
Effect of timing and route of methylprednisolone administration during pediatric
cardiac surgical procedures. [2015] cardiopulmonary bypass (CPB) prime... CONCLUSIONS: Methylprednisolone administration at anesthesia induction was
A comparison of the effects of methylprednisolone and tenoxicam on pain, edema,
and trismus after impacted lower third molar extraction. [2014] CONCLUSIONS: Preoperative administration of 80 mg methylprednisolone achieves
Efficiency of bupivacaine versus lidocaine and methylprednisolone versus placebo
to reduce postoperative pain and swelling after surgical removal of mandibular
third molars: a randomized, double-blinded, crossover clinical trial. [2013] swelling after surgical removal of mandibular third molars... CONCLUSIONS: Bupivacaine combined with methylprednisolone reduced the
Methylprednisolone in neonatal cardiac surgery: reduced inflammation without
improved clinical outcome. [2013] administration varies considerably between different institutions... CONCLUSIONS: Intravenous 30 mg/kg methylprednisolone administered before
Clinical Trials Related to Methylprednisolone
Preoperative Methylprednisolone in Endovascular Aortic Repair [Completed]
Methylprednisolone N Acetylcysteine in Hepatic Resections [Terminated]
This is a prospective double-blind randomized phase II clinical trial, with two groups of
intervention (one with administration of N-acetylcysteine and the other with administration
of methylprednisolone), and one group of placebo. The purpose of this study is to
investigate the role of N-acetylcysteine and Methylprednisolone in the modulation of warm
ischemia of the liver during hepatic resection. In fact to avoid massive blood loss in liver
surgery, continuous or intermittent vascular clamping of the hepatic hilum ('Pringle
maneuver') is generally used with good results. However, as a consequence, ischemia and
subsequent reperfusion result in complex metabolic, immunological, and microvascular
changes, which together might contribute to hepatocellular damage and dysfunction. This
phenomenon, known as ischemia-reperfusion (IR) injury of the liver, is a complex multi-path
process leading to the activation of some inflammatory pathways. Any patient candidate to
liver resection will be enrolled in the study based on the aforementioned criteria. The
primary objective of the study is to assess the real efficacy of Methylprednisolone and
N-acetylcysteine in reducing the secondary damage from ischemia reperfusion injury in liver
resection and in reducing inflammatory response. Secondary objective of the study is whether
the reduction of ischemia-reperfusion injury results in: lower incidence of postoperative
liver failure, improvement of postoperative liver function, and reduction of blood
components transfusions. The randomization will be done the day before the operation. The
drugs will be prepared in a blind fashion by the hospital pharmacy. The hospital pharmacy
will provide to each patient a drip to make bolus of about an hour before the start of the
liver resection and a syringe pump for an infusion of approximately 6 hours. If the patient
is enrolled and randomized in the placebo arm, he/she will receive 250 ml of glucose 5%
plus the infusion of 100 ml of glucose 5% If the patient is randomized in the
Methylprednisolone arm, he/she will receive a dose of 500 mg in 250 ml of glucose 5% plus
100 mg of glucose 5%. If the patient is randomized in the N-acetylcysteine arm, he/she will
receive a dose of 150 mg/kg in 250 ml of glucose 5% plus N-acetylcysteine 50 mg/kg in 100 ml
glucose 5%. Systematic sampling of liver function tests will be done the day before the
operation, at the end of the operation, as well as in postoperative day 1, 3, 5 and 7.
Efficacy Study of Adrenocorticotropin Hormone to Treat Multiple Sclerosis (MS) Relapses After Sub-responding to an Initial 3 Day Course of Intravenous (IV) Methylprednisolone [Terminated]
Cyclic Oral Methylprednisolone Trial in Multiple Sclerosis [Completed]
The purpose of this study is to determine whether cyclic oral methylprednisolone once every
month has an effect on the intrathecal inflammation in patients suffering from progressive
multiple sclerosis.
Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children [Terminated]
The purpose of this study is planned to investigate whether small doses of
methylprednisolone pulse macrolide therapy can relieve symptoms,chest X-rays faster than
macrolide alone therapy for refractory mycoplasma pneumoniae pneumonia(MPP) .
Reports of Suspected Methylprednisolone Side Effects
Pyrexia (47),
Drug Ineffective (42),
Cytomegalovirus Infection (40),
Pneumonia (33),
Aspergillosis (33),
Anaemia (29),
Respiratory Failure (27),
Sepsis (27),
Multi-Organ Failure (26),
Tendon Rupture (25), more >>
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Page last updated: 2015-08-10
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