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Methylprednisolone (Methylprednisolone) - Summary



Methylprednisolone Tablets contain methylprednisolone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.

Methylprednisolone Tablets are indicated in the following conditions:
1. Endocrine Disorders
Congenital adrenal hyperplasia     
Nonsuppurative thyroiditis     
Hypercalcemia associated with cancer
2. Rheumatic Disorders
     As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:     
Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)     
Ankylosing spondylitis     
Acute and subacute bursitis     
Synovitis of osteoarthritis     
Acute nonspecific tenosynovitis     
Post-traumatic osteoarthritis     
Psoriatic arthritis     
Acute gouty arthritis
3. Collagen Diseases
     During an exacerbation or as maintenance therapy in selected cases of:     
Systemic lupus erythematosus     
Systemic dermatomyositis (polymyositis)     
Acute rheumatic carditis
4. Dermatologic Diseases
     Bullous dermatitis herpetiformis     
Severe erythema multiforme (Stevens-Johnson syndrome)     
Severe seborrheic dermatitis     
Exfoliative dermatitis     
Mycosis fungoides     
Severe psoriasis
5. Allergic States
     Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:     
Seasonal or perennial allergic rhinitis     
Drug hypersensitivity reactions     
Serum sickness     
Contact dermatitis     
Bronchial asthma     
Atopic dermatitis
6. Ophthalmic Diseases
     Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as:     
Allergic corneal marginal ulcers     
Herpes zoster ophthalmicus     
Anterior segment inflammation     
Diffuse posterior uveitis and choroiditis     
Sympathetic ophthalmia     
Optic neuritis     
Allergic conjunctivitis     
Iritis and iridocyclitis
7. Respiratory Diseases
     Symptomatic sarcoidosis     
Loeffler's syndrome not manageable by other means     
Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy     
Aspiration pneumonitis
8. Hematologic Disorders
     Idiopathic thrombocytopenic purpura in adults     
Secondary thrombocytopenia in adults     
Acquired (autoimmune) hemolytic anemia     
Erythroblastopenia (RBC anemia)     
Congenital (erythroid) hypoplastic anemia
9. Neoplastic Diseases
     For palliative management of:     
Leukemias and Iymphomas in adults     
Acute leukemia of childhood
10. Edematous States
     To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.
11. Gastrointestinal Diseases
     To tide the patient over a critical period of the disease in:     
Ulcerative colitis     
Regional enteritis
12. Nervous System
     Acute exacerbations of multiple sclerosis
13. Miscellaneous
     Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy.     
Trichinosis with neurologic or myocardial involvement.

See all Methylprednisolone indications & dosage >>


Published Studies Related to Methylprednisolone

Double-blind, placebo-controlled pilot randomized trial of methylprednisolone infusion in pediatric acute respiratory distress syndrome. [2015]
syndrome... CONCLUSION: This study demonstrates the feasibility of administering low-dose

Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures. [2015]
cardiopulmonary bypass (CPB) prime... CONCLUSIONS: Methylprednisolone administration at anesthesia induction was

A comparison of the effects of methylprednisolone and tenoxicam on pain, edema, and trismus after impacted lower third molar extraction. [2014]
CONCLUSIONS: Preoperative administration of 80 mg methylprednisolone achieves

Efficiency of bupivacaine versus lidocaine and methylprednisolone versus placebo to reduce postoperative pain and swelling after surgical removal of mandibular third molars: a randomized, double-blinded, crossover clinical trial. [2013]
swelling after surgical removal of mandibular third molars... CONCLUSIONS: Bupivacaine combined with methylprednisolone reduced the

Methylprednisolone in neonatal cardiac surgery: reduced inflammation without improved clinical outcome. [2013]
administration varies considerably between different institutions... CONCLUSIONS: Intravenous 30 mg/kg methylprednisolone administered before

more studies >>

Clinical Trials Related to Methylprednisolone

Preoperative Methylprednisolone in Endovascular Aortic Repair [Completed]

Methylprednisolone N Acetylcysteine in Hepatic Resections [Terminated]
This is a prospective double-blind randomized phase II clinical trial, with two groups of intervention (one with administration of N-acetylcysteine and the other with administration of methylprednisolone), and one group of placebo. The purpose of this study is to investigate the role of N-acetylcysteine and Methylprednisolone in the modulation of warm ischemia of the liver during hepatic resection. In fact to avoid massive blood loss in liver surgery, continuous or intermittent vascular clamping of the hepatic hilum ('Pringle maneuver') is generally used with good results. However, as a consequence, ischemia and subsequent reperfusion result in complex metabolic, immunological, and microvascular changes, which together might contribute to hepatocellular damage and dysfunction. This phenomenon, known as ischemia-reperfusion (IR) injury of the liver, is a complex multi-path process leading to the activation of some inflammatory pathways. Any patient candidate to liver resection will be enrolled in the study based on the aforementioned criteria. The primary objective of the study is to assess the real efficacy of Methylprednisolone and N-acetylcysteine in reducing the secondary damage from ischemia reperfusion injury in liver resection and in reducing inflammatory response. Secondary objective of the study is whether the reduction of ischemia-reperfusion injury results in: lower incidence of postoperative liver failure, improvement of postoperative liver function, and reduction of blood components transfusions. The randomization will be done the day before the operation. The drugs will be prepared in a blind fashion by the hospital pharmacy. The hospital pharmacy will provide to each patient a drip to make bolus of about an hour before the start of the liver resection and a syringe pump for an infusion of approximately 6 hours. If the patient is enrolled and randomized in the placebo arm, he/she will receive 250 ml of glucose 5% plus the infusion of 100 ml of glucose 5% If the patient is randomized in the Methylprednisolone arm, he/she will receive a dose of 500 mg in 250 ml of glucose 5% plus 100 mg of glucose 5%. If the patient is randomized in the N-acetylcysteine arm, he/she will receive a dose of 150 mg/kg in 250 ml of glucose 5% plus N-acetylcysteine 50 mg/kg in 100 ml glucose 5%. Systematic sampling of liver function tests will be done the day before the operation, at the end of the operation, as well as in postoperative day 1, 3, 5 and 7.

Efficacy Study of Adrenocorticotropin Hormone to Treat Multiple Sclerosis (MS) Relapses After Sub-responding to an Initial 3 Day Course of Intravenous (IV) Methylprednisolone [Terminated]

Cyclic Oral Methylprednisolone Trial in Multiple Sclerosis [Completed]
The purpose of this study is to determine whether cyclic oral methylprednisolone once every month has an effect on the intrathecal inflammation in patients suffering from progressive multiple sclerosis.

Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children [Terminated]
The purpose of this study is planned to investigate whether small doses of methylprednisolone pulse macrolide therapy can relieve symptoms,chest X-rays faster than macrolide alone therapy for refractory mycoplasma pneumoniae pneumonia(MPP) .

more trials >>

Reports of Suspected Methylprednisolone Side Effects

Pyrexia (47)Drug Ineffective (42)Cytomegalovirus Infection (40)Pneumonia (33)Aspergillosis (33)Anaemia (29)Respiratory Failure (27)Sepsis (27)Multi-Organ Failure (26)Tendon Rupture (25)more >>

Page last updated: 2015-08-10

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