NEWS HIGHLIGHTSMedia Articles Related to Methyldopate
Seasoning May Cut Salt Needs in Hypertension (CME/CE)
Source: MedPage Today Primary Care [2013.05.18]
SAN FRANCISCO (MedPage Today) -- A greater taste for salt among older hypertensive adults might be sated by seasoning instead, a small experimental study showed.
Surprising Findings On Hypertension In Adolescents
Source: Hypertension News From Medical News Today [2013.05.07]
Teenagers with high blood pressure appear to have better psychological adjustment and enjoy higher quality of life than those with normal blood pressure, suggests a study in the May issue of Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society...
Safety-Net Clinics Face Challenges Controlling Hypertension In Their Patients
Source: Hypertension News From Medical News Today [2013.04.19]
Federally funded safety-net clinics for the uninsured lag behind other health care providers in controlling blood pressure among the low-income patients who rely on them for care, a new Michigan State University analysis suggests...
Relationship Between Obesity, Heart Disease And Hypertension
Source: Hypertension News From Medical News Today [2013.04.13]
Obesity, heart disease, and high blood pressure (hypertension) are all related, but understanding the molecular pathways that underlie cause and effect is complicated...
Preeclampsia (Pregnancy Induced Hypertension)
Source: MedicineNet Hydronephrosis Specialty [2012.05.21]
Title: Preeclampsia (Pregnancy Induced Hypertension)
Category: Diseases and Conditions
Created: 11/14/1998 4:06:00 PM
Last Editorial Review: 5/21/2012 12:00:00 AM
Clinical Trials Related to Methyldopate
A Comparison of Compliance Between Clonidine Patch and Methyldopa for the Treatment of Chronic Hypertension in Pregnancy [Recruiting]
High blood pressure (BP) before pregnancy is called chronic hypertension (CHTN), and is
associated with an increased risk of development of pregnancy related high BP called
preeclampsia, preterm delivery, decreased growth of the fetus, fetal death, premature
separation of the placenta from the uterus resulting in damage to the fetus and cesarean
delivery. Longer duration and severity of CHTN in pregnancy leads to worse outcomes for the
mother and the fetus. Treatment of mild CHTN in pregnancy does not improve these outcomes,
and therefore, medications to lower BP are used for moderate to severe hypertension. To date
the literature on the medications used in pregnancy is extremely limited.
Methyldopa is used as a first choice medicine for CHTN in pregnancy. It acts on the central
nervous system (CNS) by relaxation of the blood vessels leading to a decrease in BP. It does
not decrease the blood flow to the uterus, placenta, or the fetus (4). Methyldopa is a weak
antihypertensive medicine given three or four times a day and frequently needs changes in the
dose or may require an additional medication to control BP. This may lead to a greater chance
of non compliance. Another option is Clonidine which is an effective antihypertensive
treatment and is available in many forms (oral, parenteral, and transdermal.) It acts on the
maternal CNS. Clonidine is not associated with teratogenic or neonatal side effects.
Transdermal clonidine (catapres-TTS®) is a preparation of clonidine hydrochloride that can be
released and absorbed transdermally over a 7-day period.
The study will determine differences in compliance between the two antihypertensive regimens-
oral methyldopa and Catapres-TTS, comparisons of patient tolerability, compliance and
adequacy of BP control, as well as provide information on an alternate option for BP
control.
Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia [Recruiting]
A history of preeclampsia is associated with a low plasma volume and higher sympathetic
activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the
researchers will test that effect on the total cardiovascular balance.
Autonomic Nervous System and Chronic Fatigue Syndrome [Recruiting]
The investigators propose to test the hypothesis that the sympathetic nervous system
contributes to the cardiovascular and inflammatory abnormalities present in the chronic
fatigue syndrome (CFS) and, in particular in the subset of patients characterized by
postural tachycardia syndrome (POTS). CFS and POTS are seen mostly in otherwise normal
young women, and are the cause of significant disability. A substantial proportion of
patients referred for evaluation of POTS met diagnostic criteria for CFS and, conversely, a
subset of patients referred for treatment for CFS have POTS. The investigators hypothesize
that sympathetic activation underlies the pathophysiology of patients in whom CFS and POTS
overlap (CFS-P).
Treatment of Orthostatic Hypotension [Recruiting]
The purpose of this study is to try different medications in patients with low blood
pressure and other problems with their involuntary (autonomic) nervous system. The
pharmacological trials in this study will perhaps lead to more effective treatment. This
study consists of single dose trials, dose selection trials, 5-day trials and chronic
(approximately 2 months) trials.
The Pathophysiology of Orthostatic Hypotension [Recruiting]
The purpose of this study is to determine the cause of low blood pressure in selective
patients who have problems with their involuntary (autonomic) nervous system. These
patients frequently have had symptoms throughout their life, and their disorder might have a
genetic basis. The biochemical, physiological and pharmacological procedures in this study
should help us define the problem and perhaps lead to more effective treatment.
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