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Methyldopa (Methyldopa) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Sedation, usually transient, may occur during the initial period of therapy or whenever the dose is increased. Headache, asthenia, or weakness may be noted as early and transient symptoms. However, significant adverse effects due to methyldopa have been infrequent and this agent usually is well tolerated.

The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.

Cardiovascular: Aggravation of angina pectoris, congestive heart failure, prolonged carotid sinus hypersensitivity, orthostatic hypotension (decrease daily dosage), edema or weight gain, bradycardia.

Digestive: Pancreatitis, colitis, vomiting, diarrhea, sialadenitis, sore or "black" tongue, nausea, constipation, distension, flatus, dryness of mouth.

Endocrine: Hyperprolactinemia.

Hematologic: Bone marrow depression, leukopenia, granulocytopenia, thrombocytopenia, hemolytic anemia; positive tests for antinuclear antibody, LE cells, and rheumatoid factor, positive Coombs test.

Hepatic: Liver disorders including hepatitis, jaundice, abnormal liver function tests (see WARNINGS).

Hypersensitivity: Myocarditis, pericarditis, vasculitis, lupus-like syndrome, drug-related fever, eosinophilia.

Nervous System/Psychiatric: Parkinsonism, Bell's palsy, decreased mental acuity, involuntary choreoathetotic movements, symptoms of cerebrovascular insufficiency, psychic disturbances including nightmares and reversible mild psychoses or depression, headache, sedation, asthenia or weakness, dizziness, light-headedness, paresthesias.

Metabolic: Rise in BUN.

Musculoskeletal: Arthralgia, with or without joint swelling; myalgia.

Respiratory: Nasal stuffiness.

Skin: Toxic epidermal necrolysis, rash.

Urogenital: Amenorrhea, breast enlargement, gynecomastia, lactation, impotence, decreased libido.



REPORTS OF SUSPECTED METHYLDOPA SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Methyldopa. The information is not vetted and should not be considered as verified clinical evidence.

Possible Methyldopa side effects / adverse reactions in 15 year old female

Reported by a health professional (non-physician/pharmacist) from Brazil on 2011-10-05

Patient: 15 year old female

Reactions: Cerebral Infarction, Hypertension

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Nifedipine
    Dosage: 1 mg, unk

Methyldopa
    Dosage: 500 mg, unk

Other drugs received by patient: Diclofenac; Paracetamol; Oxytocin; Cephalexin; Betamethasone; Haloperidol; Tenoxicam; Promethazine



Possible Methyldopa side effects / adverse reactions in 43 year old male

Reported by a individual with unspecified qualification from Brazil on 2011-10-13

Patient: 43 year old male

Reactions: Blood Pressure Increased, Renal Disorder, Nausea, Heart Rate Increased, Visual Impairment, Left Ventricular Hypertrophy, Headache

Suspect drug(s):
Spironolactone
    Dosage: 25 mg,daily
    Indication: Hypertension

Hygroton
    Dosage: 25 mg, day
    Indication: Hypertension

Amlodipine
    Indication: Hypertension

Imipramine

Minoxidil
    Dosage: 10 mg day
    Indication: Hypertension

Lorazepam

Atenolol
    Dosage: 100 mg day
    Indication: Hypertension

Diovan
    Dosage: 320 mg day
    Indication: Hypertension

Methyldopa
    Dosage: 1500 mg,daily
    Indication: Hypertension

Clonidine
    Dosage: 300 mg, unk
    Indication: Hypertension



Possible Methyldopa side effects / adverse reactions in 43 year old male

Reported by a physician from Brazil on 2011-10-13

Patient: 43 year old male

Reactions: Blood Pressure Increased, Renal Disorder, Nausea, Visual Impairment, Left Ventricular Hypertrophy, Headache

Suspect drug(s):
Atenolol
    Dosage: 100 mg day
    Indication: Hypertension

Lorazepam

Diovan
    Dosage: 320 mg day
    Indication: Hypertension

Methyldopa
    Dosage: 1500 mg,daily
    Indication: Hypertension

Imipramine

Hygroton
    Dosage: 25 mg, day
    Indication: Hypertension

Amlodipine
    Indication: Hypertension

Clonidine
    Dosage: 300 mg, unk
    Indication: Hypertension

Spironolactone
    Dosage: 25 mg,daily
    Indication: Hypertension

Minoxidil
    Dosage: 10 mg day
    Indication: Hypertension



See index of all Methyldopa side effect reports >>

Drug label data at the top of this Page last updated: 2007-08-03

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