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Methocarbamol (Methocarbamol) - Summary



Methocarbamol Tablets, USP, 500 mg, a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties.

Methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties.

Methocarbamol does not directly relax tense skeletal muscles in man.

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Published Studies Related to Methocarbamol

Bioequivalence study with two different oral formulations of methocarbamol in healthy subjects. A mono-centre, comparative, randomized, open-label, single-dose, 2-way crossover study. [2009]
CONCLUSION: In this study bioequivalence could be demonstrated with respect to rate and extent of methocarbamol exposure.

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Clinical Trials Related to Methocarbamol

Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure [Completed]
Different doses of relaxin will be compared to placebo to determine efficacy and safety for the treatment of patients hospitalized with acute heart failure

Recombinant Human Relaxin for the Treatment of Decompensated CHF [Terminated]
Two doses of relaxin will be compared to placebo for the treatment of patients with decompensated CHF

A Pilot Study of Recombinant Human Relaxin (rhRlx) in Compensated Congestive Heart Failure [Completed]
This trial is a single center, open-label, dose-finding study of recombinant human relaxin (rhRlx) given intravenously (IV) to patients with stable, compensated CHF.

Evaluation of the Safety of Relaxin in Preeclampsia [Suspended]
The purpose of this study is to determine whether different doses of recombinant human relaxin is safe when given to women with severe preeclampsia

Recombinant Human Relaxin in the Treatment of Diffuse Scleroderma [Completed]
Relaxin is a naturally occurring protein prduced by the ovary or placenta in pregnancy. It has ani-fibrotic properties. Previous studies have shown that relaxin is safe at concentrations upto 60 times higher than achieved in pregnancy. Study is designed to see if skin improvement and improvement in functional ability can be achieved.

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Reports of Suspected Methocarbamol Side Effects

Chronic Obstructive Pulmonary Disease (23)Emphysema (23)Amnesia (22)Bedridden (21)Completed Suicide (8)Confusional State (5)Toxicity TO Various Agents (5)Myoclonus (5)Respiratory Arrest (4)Cardiac Arrest (4)more >>

Page last updated: 2009-10-20

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