ADVERSE REACTIONS
THE MAJOR HAZARDS OF METHADONE, AS OF OTHER NARCOTIC ANALGESICS, ARE RESPIRATORY DEPRESSION AND, TO A LESSER DEGREE, CIRCULATORY DEPRESSION. RESPIRATORY ARREST, SHOCK, AND CARDIAC ARREST HAVE OCCURRED.
The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These effects seem to be more prominent in ambulatory patients and in those who are not suffering severe pain. In such individuals, lower doses are advisable. Some adverse reactions may be alleviated if the ambulatory patient lies down.
Other adverse reactions include the following:
Central Nervous System — Euphoria, dysphoria, weakness, headache, insomnia, agitation, disorientation, and visual disturbances.
Gastrointestinal — Dry mouth, anorexia, constipation and biliary tract spasm.
Cardiovascular — Flushing of the face, bradycardia, palpitation, faintness, and syncope.
Genitourinary — Urinary retention or hesitancy, antidiuretic effect, and reduced libido and/or potency.
Allergic — Pruritus, urticaria, other skin rashes, edema, and, rarely, hemorrhagic urticaria.
Hematologic — Reversible thrombocytopenia has been described in a narcotics addict with chronic hepatitis.
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO METHADONE
Below is a sample of reports where side effects / adverse reactions may be related to Methadone. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Methadone side effects / adverse reactions in 27 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2007-01-12
Patient: 27 year old male
Reactions: Respiratory Arrest, Accidental Overdose
Adverse event resulted in: death, life threatening event, hospitalization
Suspect drug(s):
Elavil
Dosage: dose unknown at bedtime oral (duration: one dose )
Administration route: Oral
Start date: 2004-11-01
Methadone
Dosage: ? dose - total of 3 tablets a day oral
Administration route: Oral
Indication: Arthralgia
Start date: 2004-11-01
End date: 2005-01-23
Other drugs received by patient: Lexapro
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