Metformin Related Published Studies
Well-designed clinical trials related to Metformin
Efficacy and safety of pioglitazone/metformin fixed-dose combination therapy compared with pioglitazone and metformin monotherapy in treating patients with T2DM. [2009.10.14]
Metformin does not improve the reproductive or metabolic profile in women with polycystic ovary syndrome (PCOS). [2009.10]
Comparison of vildagliptin and thiazolidinedione as add-on therapy in patients inadequately controlled with metformin: results of the GALIANT trial--a primary care, type 2 diabetes study. [2009.10]
Effect of adjunct metformin treatment on levels of plasma lipids in patients with type 1 diabetes. [2009.10]
Twice-daily and three-times-daily dosing of a repaglinide/metformin fixed-dose combination tablet provide similar glycaemic control. [2009.10]
Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial. [2009.09.16]
Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial. [2009.09.02]
Rationale and design of a clinical trial to evaluate metformin and colesevelam HCl as first-line therapy in type 2 diabetes and colesevelam HCl in prediabetes. [2009.09]
The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. [2009.09]
Twice-daily dosing of a repaglinide/metformin fixed-dose combination tablet provides glycaemic control comparable to rosiglitazone/metformin tablet. [2009.09]
Effects of 1-year treatment with metformin on metabolic and cardiovascular risk factors in non-diabetic upper-body obese subjects with mild glucose anomalies: A post-hoc analysis of the BIGPRO1 trial. [2009.08.06]
Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients. [2009.08]
Extended release metformin for metabolic control assistance during prolonged clozapine administration: a 14 week, double-blind, parallel group, placebo-controlled study. [2009.08]
Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial. [2009.08]
Metformin in combination with structured lifestyle intervention improved body mass index in obese adolescents, but did not improve insulin resistance. [2009.08]
Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. [2009.07]
Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). [2009.07]
Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial. [2009.06]
Study of the pharmacokinetic interaction of vildagliptin and metformin in patients with type 2 diabetes. [2009.05]
Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled, clinical trial. [2009.05]
Pharmacology and tolerability of a single dose of exenatide in adolescent patients with type 2 diabetes mellitus being treated with metformin: a randomized, placebo-controlled, single-blind, dose-escalation, crossover study. [2009.04]
Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients. [2009.04]
Nateglinide combination therapy with basal insulin and metformin in patients with Type 2 diabetes. [2009.04]
Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects. [2009.04]
Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes. [2009.04]
Study rationale and design of the CIMT trial: the Copenhagen Insulin and Metformin Therapy trial. [2009.04]
Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus. [2009.03.23]
Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. [2009.03.05]
Is it time to test metformin in breast cancer clinical trials? [2009.03]
One-Year Treatment With Exenatide Improves Beta-Cell Function, Compared To Insulin Glargine, In Metformin Treated Type 2 Diabetes Patients: A Randomized, Controlled Trial. [2009.02.05]
Metformin effects on clomifene-induced ovulation in the polycystic ovary syndrome. [2009.01]
Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial. [2009]
The effect of ethinylestradiol (EE)/cyproterone acetate (CA) and EE/CA plus metformin treatment on adhesion molecules in cases with polycystic ovary syndrome (PCOS). [2009]
Soluble CD40 ligand, plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor-1-antigen in normotensive type 2 diabetic subjects without diabetic complications. Effects of metformin and rosiglitazone. [2009]
Pioglitazone metabolic effect in metformin-intolerant obese patients treated with sibutramine. [2009]
Increased Insulin Sensitivity by Metformin Enhances Intense-Pulsed-Light-Assisted Hair Removal in Patients with Polycystic Ovary Syndrome. [2008.12.18]
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions. [2008.12]
Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. [2008.12]
The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials. [2008.11]
Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes mellitus (LEAD-2 Met). [2008.10.17]
Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects. [2008.10.13]
Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome. [2008.10]
Does metformin augment the ovulation inducing effects of clomiphene in non-obese women with polycystic ovary syndrome? [2008.10]
Prevention of Diabetes in Women with a History of Gestational Diabetes: Effects of Metformin and Lifestyle Interventions. [2008.09.30]
Improvement of glycaemic and lipid profiles with muraglitazar plus metformin in patients with type 2 diabetes: an active-control trial with glimepiride. [2008.09]
The Impact of Metformin, Oral Contraceptives and Lifestyle Modification, on Polycystic Ovary Syndrome in Obese Adolescent Women in Two Randomized, Placebo-Controlled Clinical Trials. [2008.08.26]
Extended-Release Metformin Does Not Reduce the Clomiphene Citrate Dose Required to Induce Ovulation in Polycystic Ovary Syndrome. [2008.08]
A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents. [2008.08]
Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome? [2008.08]
Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin. [2008.07]
Effects of metformin and ethinyl estradiol-cyproterone acetate on clinical, endocrine and metabolic factors in women with polycystic ovary syndrome. [2008.07]
Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome. [2008.07]
How does blood glucose control with metformin influence intensive insulin protocols? Evidence for involvement of oxidative stress and inflammatory cytokines. [2008.07]
Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. [2008.06]
Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome. [2008.06]
Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixed-dose combination tablet in healthy volunteers. [2008.06]
Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study. [2008.06]
Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study. [2008.05.30]
Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome. [2008.05.27]
Metformin versus insulin for the treatment of gestational diabetes. [2008.05.08]
Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes. [2008.05]
Metformin treatment for four years to reduce total and visceral fat in low birth weight girls with precocious pubarche. [2008.05]
Rosiglitazone therapy improves insulin resistance parameters in overweight and obese diabetic patients intolerant to metformin. [2008.05]
Bioequivalence of vildagliptin/metformin fixed-dose combination tablets and a free combination of vildagliptin and metformin in healthy subjects. [2008.05]
The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study. [2008.05]
Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: a randomized controlled trial (the RECORD study). [2008.04.24]
Use of metformin in obese adolescents with hyperinsulinemia: a 6-month, randomized, double-blind, placebo-controlled clinical trial. [2008.04]
Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial. [2008.03.03]
Examination of metformin hydrochloride in a continuous dissolution/HDM system. [2008.03.03]
Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study. [2008.03]
Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects. [2008.03]
Meta-analysis: metformin treatment in persons at risk for diabetes mellitus. [2008.02]
Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. [2008.02]
Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial. [2008.01.09]
Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes. [2008.01]
Safety and efficacy of repaglinide in combination with metformin and bedtime NPH insulin as an insulin treatment regimen in type 2 diabetes. [2008.01]
Serum transforming growth factor-beta 1 levels in normoalbuminuric and normotensive patients with type 2 diabetes. Effect of metformin and rosiglitazone. [2008.01]
Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes. [2008.01]
Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with Type 2 diabetes inadequately controlled on metformin alone. [2008.01]
Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study. [2008.01]
[Efficacy and safety of the use of metformin in patients with chronic heart failure and type 2 diabetes mellitus. results of the study "rational effective mulicomponent therapy in the battle against diabetes mellitus in patients with chronic heart failure"] [2008]
Effect of adjunct metformin treatment in patients with type-1 diabetes and persistent inadequate glycaemic control. A randomized study. [2008]
Fixed-Dose Combination Tablet of Repaglinide and Metformin is Bioequivalent to Concomitantly Administered Individual Tablets of Repaglinide and Metformin : Randomized, Single-Blind, Three-Period Crossover Study in Healthy Subjects. [2008]
Metformin has no major effects on glucose homeostasis in pregnant women with PCOS: results of a randomized double-blind study. [2008]
Effect of rosiglitazone and metformin on insulin resistance in patients infected with human immunodeficiency virus receiving highly active antiretroviral therapy containing protease inhibitor: randomized prospective controlled clinical trial. [2007.12]
Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and rosiglitazone or insulin and acarbose in type 2 diabetes. [2007.12]
Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled cross-over trial. [2007.11]
Comparison of biphasic insulin aspart 30 given three times daily or twice daily in combination with metformin versus oral antidiabetic drugs alone in patients with poorly controlled type 2 diabetes: A 16-week, randomized, open-label, parallel-group trial conducted in russia. [2007.11]
Flutamide metformin for post-menarcheal girls with preclinical ovarian androgen excess: evidence for differential response by androgen receptor genotype. [2007.11]
Metabolic effects of rosiglitazone and metformin in Greek patients with recently diagnosed type 2 diabetes. [2007.11]
Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison. [2007.11]
Mealtime 50/50 basal + prandial insulin analogue mixture with a basal insulin analogue, both plus metformin, in the achievement of target HbA(1c) and pre- and postprandial blood glucose levels in patients with type 2 diabetes: A multinational, 24-week, randomized, open-label, parallel-group comparison. [2007.11]
Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: A multinational, randomized, open-label, two-period, crossover noninferiority trial. [2007.11]
Effect of glyburide-metformin combination tablet in patients with type 2 diabetes. [2007.11]
Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study. [2007.11]
Normalization of metabolic syndrome using fenofibrate, metformin or their combination. [2007.11]
A randomized placebo-controlled trial of metformin for the treatment of HIV lipodystrophy. [2007.10]
A comparison of mealtime insulin aspart and human insulin in combination with metformin in type 2 diabetes patients. [2007.10]
Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin. [2007.09]
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. [2007.09]
Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naive patients with Type 2 diabetes. [2007.09]
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