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Metformin (Metformin Hydrochloride) - Summary

 
 



METFORMIN SUMMARY

Metformin Hydrochloride (HCl) Tablets, USP is an oral antihyperglycemic drug used in the management of type 2 diabetes.

Metformin HCl Tablets, USP are indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 2 diabetes mellitus.


See all Metformin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Metformin

Medical News Today: New metformin may help more patients with type 2 diabetes
Source: Featured Health News from Medical News Today [2015.08.20]
A study that overturns ideas about where metformin acts in the body suggests a delayed-release version could help the 40% of type 2 diabetes patients who are unable to use it.

New metformin may help more patients with type 2 diabetes
Source: Diabetes News From Medical News Today [2015.08.20]
A study that overturns ideas about where metformin acts in the body suggests a delayed-release version could help the 40% of type 2 diabetes patients who are unable to use it.

Delayed Release Metformin Sails Through Phase II Testing (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2015.08.20]
(MedPage Today) -- The new version changes the target without changing the formula

Diabetes Drug Metformin May Lower Glaucoma Risk
Source: MedicineNet Glaucoma Specialty [2015.05.29]
Title: Diabetes Drug Metformin May Lower Glaucoma Risk
Category: Health News
Created: 5/28/2015 12:00:00 AM
Last Editorial Review: 5/29/2015 12:00:00 AM

Type 2 Diabetes Can Be Prevented: Why Are We Waiting?
Source: Medscape Diabetes & Endocrinology Headlines [2015.08.17]
Despite the evidence supporting benefit, clinicians have been slow to recommend either healthy lifestyle changes or metformin for diabetes prevention.
Medscape Diabetes & Endocrinology

more news >>

Published Studies Related to Metformin

Anagliptin and sitagliptin as add-ons to metformin for patients with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, active-controlled, phase III clinical trial with a 28-week extension. [2015]
We conducted a 24-week, multicentre, double-blind, randomized study with a 28-week extension to compare the efficacy and safety of anagliptin and sitagliptin as an add-on to metformin in patients with type 2 diabetes. Patients inadequately controlled on metformin were randomized to either anagliptin (100 mg twice daily, n = 92) or sitagliptin (100 mg once daily, n = 88)...

Effect of combination therapy with repaglinide and metformin hydrochloride on glycemic control in Japanese patients with type 2 diabetes mellitus. [2014]
exercise... CONCLUSIONS: Combination therapy with repaglinide and metformin resulted in an

Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with type 2 diabetes and coronary artery disease. [2014]
CONCLUSIONS: Our findings revealed the differential therapeutic effects of

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial. [2014]
diabetes... INTERPRETATION: Metformin had no effect on cIMT and little or no effect on

The effect of metformin on apoptosis in a breast cancer presurgical trial. [2013]
presurgical trial... CONCLUSION: Overall, we found no significant modulation of apoptosis by

more studies >>

Clinical Trials Related to Metformin

Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance [Active, not recruiting]
The primary objective of this randomized, parallel group, double-blind, placebo-controlled study is to determine whether treatment with metformin enhances insulin sensitivity in a group of ethnically diverse obese insulin-resistant adolescents with normal glucose tolerance.

Drug Interaction With Metformin [Completed]
The purpose of the study is to determine the effect of metformin on dapagliflozin exposure and the effect of dapagliflozin on metformin exposure in healthy volunteers. Additionally, the safety and tolerability of dapagliflozin will be assessed in the presence and absence of metformin in healthy volunteers

Rosiglitazone-Metformin Combination Versus Metformin-Sulfonylurea Combination On Beta-Cell Function In Type 2 Diabetes [Active, not recruiting]
It has been shown in previous study that progressive glycemic deterioration was associated with progressive loss of b-cell function, measured by the decrease in plasma insulin levels, irrespective of the therapy used (diet, sulfonylureas or metformin).There is growing evidence that thiazolidinediones could have a positive action on the b-cell function. But it has not yet been demonstrated that they could protect from a deterioration in insulin secretion in the long term. So, it appears interesting to study the long term evolution of the b-cell function and the possible protection with rosiglitazone in patients with type 2 diabetes showing evidence of loss of b-cell function with metformin alone.

Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 Diabetes [Active, not recruiting]
to demonstrate the efficacy of inhaled Technosphere/Insulin in combination with metformin versus combination metformin and a secretagogue

To Compare the Effect of Liraglutide When Given Together With Metformin With the Effect of Metformin Given Alone and With the Effect of Glimepiride and Metformin Given Together [Active, not recruiting]
This trial is conducted in Europe, Oceania, Africa, Asia and South America.

This trial is designed to show the effect of treatment with liraglutide when adding to existing metformin therapy and to compare it with the effects of metformin monotherapy and combination therapy of metformin and glimepiride.

The 26 weeks double-blind period will be followed by an 18 months open label extension.

more trials >>

Reports of Suspected Metformin Side Effects

Renal Failure Acute (5)Hypotension (4)Lactic Acidosis (3)Suicide Attempt (3)Intentional Overdose (2)Hypoglycaemia (2)Completed Suicide (2)Blood Creatinine Increased (2)Dyspnoea (2)Diarrhoea (2)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 20 ratings/reviews, Metformin has an overall score of 8.05. The effectiveness score is 8.20 and the side effect score is 8.20. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Metformin review by 30 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   pcos
Dosage & duration:   2000mg/day taken twice a day for the period of 4 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   As for Polycystic Ovary Syndrome patient, the main goal of the treatment was to regulate ovulation, and to regulate menstrual period. After 4 months of treatment (only 2 months therapeutic dose), I become pregnant and now have a beautiful son.
Side effects:   Persistant nausea, diarrhea after every single dose.
Comments:   Treatment started as a very low dose at 500mg/day at the evening meal. Dose was increased by 500mg on the second week and stayed the same for 3 weeks. On week 5 dose was increased by 500mg for another 2 weeks. Another 500mg increase up to 2000mg/day until beginning of the pregnancy.

 

Metformin review by 41 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   none
Dosage & duration:   2 g a day (dosage frequency: twice) for the period of 1 year
Other conditions:   none
Other drugs taken:   alpha-lipoic acid
  
Reported Results
Benefits:   Well... what can I say? During the treatment I mentioned a considerable pressure decrease, and for sure it was a notable blood sugar decrease. I would recommend this drug to evedybody with sugar diabetes type II. Adherence to a diabetic diet is an important aspect of controlling elevated blood sugar in patients with diabetes. The American Diabetes Association (ADA) has provided guidelines for a diabetic diet. The ADA diet is a balanced, nutritious diet that is low in fat, cholesterol, and simple sugars. The total daily calories are evenly divided into three meals. In the past two years, the ADA has lifted the absolute ban on simple sugars. Small amounts of simple sugars are allowed when consumed with a complex meal. For more, please read the Diabetic Diet article.
Side effects:   none
Comments:   as prescribed

 

Metformin review by 50 year old male patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   diabetes
Dosage & duration:   max allowed (dosage frequency: daily) for the period of 120 days
Other conditions:   high blood pressure; depression; sleep apnea
Other drugs taken:   aspirin, Lasix
  
Reported Results
Benefits:   There was no perceptible benefit to the patient from his point of view; there was an apparent improvement as measured by the doctor. The doctor advised continuation of the treatment.
Side effects:   There was no perceptible side effect experienced by the patient; this is possibly possibly due to the inattentive nature of the patients deep depression. The patient also had extreme sleep apnea.
Comments:   Started the treatment for 60 days at maximum recommended rate; the patient found no perceptible improvement he then trailed off to stop treatment over the following 60 days.

See all Metformin reviews / ratings >>

Page last updated: 2015-08-20

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